Tag Archives: diabetes

Pathogen Uses of Cloaking Devices Disrupted

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Pathogen CloakingIn the much-watched Star Trek program, the dastardly Klingons would cloak their ships so that they were invisible to the USS Enterprise. In the human body, pathogens also cloak themselves to be invisible, seem like sugar or a food, by using sialic acids. Sialic acids are common on the cells of vertebrates and are the highest concentration in the brain. The immune system will not attack pathogens with sialic acid attached because they appear as a natural part of the human system. Dr. P. R. Raghavan has found that Metadichol, by expressing the CD33 gene, allows binding of these acids so that the immune system can disrupt the pathogen.
There have been many papers published on human healing by Dr. Raghavan that include increase in stem cells, reduction of diabetes, and general well being realized with the use of Metadichol. The finding of the binding of sialic acid with the expression of CD33 and the increase in stem cells explains the healing of wounds quickly when using Metadichol.
Below is a recently published paper by Dr. Raghavan on this topic. Metadichol acts to up regulate or down regulate CD33 depending on signaling mechanisms in human physiology.

Metadichol® and CD33 Expression in Umbilical Cord Cells

Abstract
CD33 also known as Siglec-3 is endogenously expressed in stem cells and is a marker for the myeloid lineage of cells. Increased expression of CD33 thus allows it to bind to any Sialic Acids (SIAs). These acids are binding sites for pathogens and toxins. By binding to these acids, CD33 can prevent invasion of hosts by these pathogens. Down-regulation of CD33, increase the release of the pro-inflammatory cytokine TNF-α by monocytes that increases reactive oxygen species that are involved in diseases like diabetes mellitus, Alzheimer’s, cardiovascular diseases asthma, and in various cancers.
     The up-regulation of CD33 using Metadichol® was studied using Wharton’s Jelly Mesenchymal Stem Cells (MSCs) isolated from human umbilical cord and were grown in p-35 dishes until confluent and treatment was carried out with different concentrations. One dish was untreated and considered as control. The treated and untreated cells were analyzed using Flow Cytometry. The cells treated at 100 pg of Metadichol® has shown the highest increase (>400 fold) in CD33++ expression (48.77%) compared to untreated control (0.11%).
Link to paper: CD33-paper
This paper may be difficult to digest. However, that should not stop you from using Metadichol for whatever ails you. This is a link for the 29 articles with links to Dr. Raghavan’s papers that I have published on Metadichol.  –Mark Pegram

The Fountain of Youth, Metadichol?

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INSERT CLOTHOClotho is one of the three Greek fates that are responsible for the thread of life in Greek mythology. Clotho is known as the spinner of the thread while the others draw out and cut. In our understanding of physiology, we have named the gene responsible for reduced chronic disease—Klotho. The up regulation of klotho appears to significantly reduce chronic disease. A few to consider are cancer, diabetes, rheumatoid arthritis, and coronary artery disease. Have we stumbled unto the gene that is responsible for the fountain of youth?

The klotho gene appears to be regulated by constituents of the vitamin D family, especially the vitamin D nuclear receptor (VDR). In the past, DR. P. R. Raghavan has shown that Metadichol acts to regulate VDR. In the paper, “Metadichol a Novel Agonist of the Anti-aging Klotho Gene in Cancer Cell Lines,” it is shown how Metadichol up regulates klotho in pancreatic cancer cells by as much as ten-fold against controls. Here is the link to the paper: METADIHCOL-KLOTHO

Here is the paper abstract:

Abstract

Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of life. Klotho is a transmembrane protein known to be a co-receptor for Fibroblast Growth Factor-23. Klotho gene is expressed in a variety of tissues changes in the levels are associated with many diseases. Klotho is a tumor suppressor in breast cancer and its expression is reduced in human pancreatic adenocarcinoma, and treatment with klotho inhibits the growth of pancreatic cancer cells in vitro and in vivo.

Growing evidence suggests that an increase in Klotho (KL) expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. It remains a challenge today to induce Klotho expression. Herein we show that treating pancreatic cancer cells PANC1, MIAPACA and COLO-205 with Metadichol® a novel food-based lipid emulsion of long chain alcohols at picogram/ml, concentration led to a 4 to10 fold increase in Klotho expression as seen quantitative RT-PCR. These results suggest the use of Metadichol® given its constituents that are present in foods we consume every day is a novel therapeutic intervention for pancreatic cancer and other diseases.

The importance of vitamin D and common food compounds like the long chain alcohol lipids that comprise Metadichol is once again shown. We did not have to spend years in Florida looking for the fountain of youth. I bet Ponce de Leon would be very jealous. –Pandemic Survivor.

Metadichol and Glucose Transport

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Once again Dr. P. R. Raghavan has demonstrated how Metadichol works to improve health. In a recent paper, published in the Journal of Stem Cell Research & Therapy, Metadichol is shown to affect the glucose transporter 4 (Glut4 – found primarily on muscle cells) and associated receptor substrates. This explains the control of glucose in patients treated with Metadichol in many case studies.  “Umbilical Cord Treatment with Metadichol, IRS and Glut4 Expressions and Implications for Diabetes” Link to Paper as PDF: IRS-GLUT4-PAPER

It is important to understand that this is a new paradigm for treatment of disease. Typically, in medical treatment research, it has been “one drug–one target.” In the above paper, it is shown how a new understanding of treatment is obtain with “one drug–multiple targets.”  When gene expression as well as nuclear receptors are brought into proper communication, amazing things happen.

Glucose transporters have been shown to increase the transfer of sugars through cell membranes in several ways. Of course, insulation regulation has always been the obvious control of sugar uptake by cells. It is also well known that exercise significantly increases the action of Glut4 which is the transporter for muscle cells. In addition, thyroid hormones play an important role in glucose transporters (which means that iodine and selenium are important). Now for the first time, the regulation of glucose transporters is shown to be affected by a food substance.

Metadichol is a nano-emulsion of waxy aliphatic alcohols, policosanols. The difference of Metadichol and other policosanol supplements is the small particle formulation. Policosanols can be found in many plants. Modern processing of foods has significantly changed the way our bodies take up policosanols. The most concentrated areas of policosanol are on the surface of leaves and husk of seeds and grains.

This is exciting news for diabetics who may be able to control their blood sugar with a substance that does not have side effects, Metadichol. 

 

References:

Glucose Transporters–Wikipedia

Signaling Mechanisms that Regulate Glucose Transport

Glut4–Wikipedia

Glucose Transport Pathway

Diabetes Solution – Metadichol

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Sym DiabeticA novel approach to solving the issues of diabetes shows Metadichol to be a winner.  Dr. PR Raghavan had originally published a paper for a case study for type 1 diabetes, Case Report of Type 1 Diabetes. Journal of the Science of Healing Outcomes: 2010; Vol 2(8/9):24. After five years and ending treatment the patient is still producing insulin.

  He is now to publish in the Science of Healing Outcomes in July a case report for type 2 diabetes.  Metadichol and Type 2 Diabetes Case Report (Metadichol Type2 Diabetes). From the introduction: “Globally, it is estimated that 366 million people had diabetes in 2011 (5). The number of people with type 2 diabetes is rapidly increasing in every country and in some low to middle income countries, up to 80% of people have diabetes.”  This disease ravishes the body and ultimately causes death from organ failure.  It is a disease of poor eating habits: “Type 2 diabetes is a metabolic disease that can be prevented through lifestyle modification, diet control, and control of overweight and obesity. Education of the populace is still the key to control this emerging epidemic.”

Figure 8The results from the case study are amazing as the person was on no other meds, having chosen to use only Metadichol.  The figure 8 graph from the study shows a clear reduction in glucose as tested during various times throughout the day. The patient’s HbA1C was reduced from 9.8 at baseline to 6.2 at day 84.

Is Metadichol going to work for diabetics?  This is yet to be determined. This study of one person may have had significant changes in glucose because the person changed their eating and exercise habits.  Eating habits are not reported and do have a significant impact on type 2 diabetes.  However, the case study that was first reported for type 1 warrants a significant clinical trial to determine the efficacy for Metadichol for treating diabetes. Since policosanol (the primary component of Metadichol) is a food substance, this trial could be safely carried out on large populations with people that are willing to log their eating habits during the trial.

As reported in other articles on Metadichol, Dr. Raghavan believes that the effectiveness is from how nano-policosanol acts on the vitamin D receptor (VDR).  It appears to act as both an agonist and an inverse agonist which is very unusual.  In addition, Metadichol acts on many genes and other nuclear receptors as reported by Dr. Raghavan.  Will the medical community embrace a food substance for treating disease—all, yet to be determined?  – Pandemic Survivor

Nano Policosanol Study Shows Increased Vitamin D

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Recently a clinical trial was started with 32 patients with many medical issues. P. R. Raghavan, Ph.D. has provided me with some of the initial results of the trail after thirty days.  There are sixty markers for health being used in the study.  The patients are being given 5 mg of per day of Metadichol (nano policosanol) and the markers being tested periodically.

The very interesting thing is that the vitamin D levels (25(OH)D) of the patients have improved by 38.2%.  The baseline for the trial was an average of 12.75 ng/ml.  After thirty days, the average of the group increased to 17.77 ng/ml.  The following graph shows the results of 31 patients with one of the patients left out as there was no change in vitamin D. This gives the result of an increase for 31 patients at 39.4%.  There was no supplementation of vitamin D or increased exposure to sunshine to account for this increase.

PastedGraphic-1

In Dr. Raghavan’s findings for Metadichol, he has shown through nuclear receptor studies that Metadichol can act as an agonist, antagonist, and as an inverse agonist for the vitamin D receptor.  In conversations with Dr. Raghavan, he believes that Metadichol acts in place of vitamin D or as a helper to make the action of vitamin D more effective.  He states that the vitamin D receptor is like the conductor of an orchestra to allow other nuclear receptors to properly react for health. I asked him how the nano policosanol knows how to control the receptors.  He states that he believes it is through the communication of the genes in food with the human genome. 

The details of the complexity of nano policosanol interaction with the human genome is yet to be completely determined.  However, many thousands have taken Metadichol as a supplement in Asia for over a year with only positive results of health being reported.  Policosanol is the waxy aliphatic alcohol that is found on the sun exposed portion of many plants.  The Cubans have found in studies that policosanol is very effective in reducing total cholesterol and triglycerides and increasing HDL, the more desirable form of cholesterol for health.  In addition, Dr. Raghavan has shown that Metadichol affects many of the markers for health which include blood sugar and insulin response.  We will know more when the trial is completed.  The Chinese have allowed the product to be marketed as boosting the immune system. It is particularly effective for wound healing and Dr. Raghavan also plans to show how Metadichol affects metabolic age. 

Metadichol in Southeast Asia

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A video of people using Metadichol as brand name Polilex has been posted to you tube by Polilex. This is a very remarkable video. Typically what you see in videos is young people talking about how wonderful things are. In this video, it is mostly old people that are suffering from an array of chronic diseases.

It is amazing to think that something as simple as an emulsion of the waxy substance found on most plants leaves can have such effects. As we move forward in our understanding of nutrients from food, I believe there will be amazing results. How modern foods are processed is of extreme importance to our health.

The video is high quality but the English subtitles are sometimes hard to read.

New Nutraceutical, Metadichol® – Breathtaking Results!

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“One good nutraceutical can wipe out the drugs.” Dr. Stephen De Felice

As a regular reader, you have seen several post of the new form of policosanol as a small droplet emulsion, brand name, Metadichol®. (Historic Breakthrough in Health – A Natural Alternative to Vitamin D) This natural substance appears to present a new model for how healing should occur in the body. As a natural substance formed on sun splashed portions of plants, it appears to act in the body very similar to vitamin D. This is a claim in the one of the many patents covering Metadichol®. As you know, you cannot patent a natural substance; however, the novelty is the small droplet that easily absorbs into the body and blood stream where it can become active in cells.

Some of the claims in the patent for healing are as follows: malaria, acne, eczema, ganglion, lipoma, MRSA, wound healing, fungal infections, psoriasis, hair growth, wrinkles, kidney disease, regulates glucose, insulin resistance, Diabetes type 2, Cholesterol, improved lipid profiles, hypertension, kidney disease, heart disease, reduced protein oxidation or oxidative stress, TNF a – significant immune system function, and increases serum vitamin C.

This product has only been on the market since the last part of 2014 in Southeast Asia. The reports coming from that area are amazing in the variety and healing of many diseases. The amazing thing has been no side effects. Of course, since it can be found of most foods, there should be no side effects. This appears to fall into the first rule of medicine, do no harm. When I was first approach by the discoverer, I thought – yeah, yeah another nut found a way to make money. Now after two months, I am truly amazed at the results from my own experience.

My own experience was first the amazement that the pain from my wife’s shingles went away in just a couple of days. It is interesting to note that her primary care physician had identified the rash as shingles along the C3-C4 dermatome. My wife has experienced shingles before that went on for over six months. After four weeks, there was still some redness and my wife went to see a dermatologist who is a friend of the family (I may have instigated this visit because of my prior communication with the dermatologist about Metadichol®). The dermatologist said that it was not shingles, primarily because it had gone away so fast and the apparent appearance of the remaining rash. She described it as a rash of unknown origin. I suspect this type of healing is unfamiliar to the dermatologist.

As for myself, I had a hemorrhoid that shrank overnight after an application of Metadichol®. Also, I treated a wound that I had received from cutting wood. It healed very quickly without a scab formation which I found extremely interesting. After about four weeks of using Metadichol®, there were red formations on my arm and leg. They appeared to be like large pimples or a formation of a colony of bacteria that looked similar to the appearance of MRSA that I had five years ago. After a few days of treatment with the Metadichol®, the redness disappeared. I now wonder if these areas were not colonies of pathogens trying to escape from the action of the Metadichol®. Also, the lipomas are shrinking on our 13 year old dog. We simply spray a couple of sprays on her food every day. We tried to treat a lick granuloma on the dog’s leg. This appeared to work well for a couple of weeks, but the dog started to lick again and the inflammation still exists. We have not tried to increase the dose for the dog. Also intermittent treatment may be an issue as well.

The mechanisms for how the substance works is not truly understood. Dr. Raghavan, the discoverer believes that there is some form of communication that appears to give intelligence to the action of Metadichol®. He has tried the formulation with synthetic components of policosanol and it does not work. He believes that it may be plant and microbial DNA that gets extracted along with the policosanol. It would be interesting if the Metadichol® is also renewing the health of our microbiome and homeostasis is reached in the body through this symbiotic relationship. The consideration of how it may possibly work because of DNA that comes over is daunting when considering the amounts of GMO foods that we are now consuming.

There are to be publications about Metadichol® that will appear over the next several months. This will include information on how our genome reacts and treatment of some very serious diseases. It will be interesting the response of the medical and research communities. – Pandemic Survivor

“Human subtlety will never devise an invention more beautiful, more simple, or more direct than does Nature— because in her inventions, nothing is lacking— and nothing is superfluous.” Leonardo da Vinci

Higher Vitamin D Intake Drastically Reduces Disease

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A new study of serum levels of vitamin D shows that 4000 to 8000 IU per day are required to keep your serum level in a range that will reduce the incidence of disease. This includes cancer, type 1 diabetes, and multiple sclerosis.  Dr. Cedric Garland says that the incidence of many diseases could be reduced by half.

Here is the news article in Business Week: “Higher Vitamin D Level Could Cut Cancer Risk”

As I have described in many post, the amount of vitamin D required is different for each individual.  The only way to know that you are getting enough is to have your serum 25(OH)D level tested.  Serum levels should be maintained above 40 ng/ml, and for best results the level should be maintained between 60 to 80 ng/ml year round.  You should only supplement with Vitamin D3.

For a better understanding of the science, here is the journal article that was published in Anticancer Research, International Journal of Cancer Research and Treatment, made available in its entirety by Grass Roots Health.

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention

CEDRIC F. GARLAND, CHRISTINE B. FRENCH, , LEO L. BAGGERLY, and ROBERT P. HEANEY (here is the url in case you cannot go there from the above link  http://www.grassrootshealth.net/garland02-11)

“This paper provides a long awaited insight into a dose-response relationship between orally administered vitamin D3 and the resulting levels of serum 25(OH)D in over 3600 citizens. The results will allow new definition of high vitamin D dose safety and reduce concerns about toxicity. This is a landmark contribution in the vitamin D nutrition field!”

– Pandemic Survivor

Millions Needlessly Die of Vitamin D3 Deficiency

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Well, in my satire on the presidential declaration of a national emergency it seems that I got my numbers wrong about the amount of death from vitamin D deficiency.   I had used 400,000 deaths that is an extrapolation used in William Grants paper on what would happen if everyone in the US were to take 2000 IU of D3 per day.  “Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.” http://www.sunarc.org/GrantGrassrootsHealth.pdf Since Dr. Grant wrote this paper that used data from 2001 new research has come to light.

I received an email today from the John Cannell, Vitamin D Council, that said that William Faloon, Co-Founded of Life Extension Foundation, had written a new article with a retraction of his data from the letter of 2007.  http://www.lef.org/magazine/mag2007/oct2007_awsi_01.htm His new numbers that appeared in the January, 2009 issue of Life Extension Magazine shows that there could be well over a million deaths in the US every year from vitamin D deficiency.  http://www.lef.org/magazine/mag2009/jan2009_Millions-of-Needless-Deaths_01.htm

So what are we to believe?  I always like to check my data from an independent source.  If we consider that vitamin D has the possibility of reducing all chronic disease by 40 percent what would that mean for America?  If you will recall my post on Health Care Reform Heal the People we found that the death rate in Mexico is 4.8 per 1000 per year and in the US the death rate is 8.4 per 1000 per year,  or 43% less deaths per year in Mexico.  CIA Fact Sheets:  https://www.cia.gov/library/publications/the-world-factbook/rankorder/2066rank.html So you ask what the disparity of data is.  Do they have a better health care system?  The answer of course is that they are a sun-splashed country in the lower latitudes which means they most likely have higher vitamin D levels than the US.  And not only that,  but much of the population lives above 5000 ft which is above much of the atmospheric moisture and pollutions and this allows a higher incidence of UVB radiation to make vitamin D.  Also their winters are not as cold so more of the human body is exposed because they simply wear fewer clothes.

The death rate in the US of 8.4 minus the death rate of 4.8 is 3.6 per 1000 population per year.  If we take that most of this is from the difference in vitamin D levels then the US could reduce death by 3.6 times 307,000 thousand (307 million US population) per year.  This works out to 1,150,000 people per year.  If we say that there are more deaths because we have more cars and higher incidence of toxins because we are (were) a more industrialized nation, we would still have well over a million less deaths from vitamin D3 deficiency every year.  This would decimate the medical and medical insurance industries to say nothing of big pharma and over-the-counter goods sold at retail as remedies for whatever.  If the deaths are reduced by this much imagine how much less suffering and pain there would be from disease.

This is one heck of a survivor story as Mexico has significantly less death and suffering than the US because of vitamin D3.  I know the above may not be very scientific but it makes a lot of just plain common sense.  Imagine the millions of needless deaths in other countries because of this dread deficiency in a world with a population 6.7 billion people with a large portion living at the higher latitudes.

William Faloon sent this article to all Congressmen and Senators:  http://www.lef.org/magazine/mag2009/jan2009_Millions-of-Needless-Deaths_01.htm

While you are basking in the sun write your Congressman, The President, and the Secretary of Health and tell your friends.    – Pandemic Survivor

Improving Insulin Sensitivity

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I read an article in the Wilmington Star News online that says that vitamin D is more effective than one of the major meds for controlling blood sugar.  I am surprised that a pharmacist was willing to actually state the truth.  I say congratulations for a job well done.  Before we get into that let me tell you about a friend that I know that struggled with type two diabetes.

I had told him about the research on vitamin D and diabetes and he was excited to try and keep his serum level up as a means to achieve better health.  After he started to supplement with vitamin D he said that he did not ‘sense’ the extreme up and downs in his blood sugar.  He also said that this helped him to better control his appetite and he lost thirty pounds over a six month period.  He got off all the meds for type 2 diabetes.  Now his fasting blood sugar is normal.  I am not saying that taking the vitamin D healed his type 2 diabetes.  I am sure that the loss of the weight had a significant impact.  In any case we have another survivor of a significant chronic disease and better he did it without staying on pharmaceuticals.

Okay so here is the story for the Star News online where this pharmacist says that vitamin D is five times better than one of the meds known as the ‘gold standard’ for treating insulin sensitivity.  I find this most amazing!  “A ‘D’ once a day will keep the doctor away”

If your doctor does not believe that vitamin D will have this kind of effect then I would suggest that you have him read the research that the pharmacist refers to.  Also a really good paper is one by Dr. Heaney of Creighton University where he describes blood sugar being blunted and insulin response improves once your blood serum 25(OH)D is above 32 ng/ml (80 nmol/l).  The name of the paper is ‘The Vitamin D requirement in health and disease’ as published in J Steroid Biochem Mol. Bio.  Oct. 2005.

Taking a lot of vitamin D if you have type 2 diabetes is not going to do that much good if you choose to keep eating sugary and starchy foods.  Even the best attempt at good health cannot overcome emotional eating.  (you know I am overweight and love to eat lots of cheeseburgers and my lipids and blood sugar are excellent and they were not before vitamin D – I should ‘practice what I preach’ ) You may ( I am beginning this techniques myself) want to try the new emotional control techniques using motion that are being used like EFT (emotional freedom technique ).

Eat Healthy and go into the sun!                   – Pandemic Survivor