Vitamin D, Disease, and Research

In 2006, I went to PubMed, the government clearing house for medical publications, and just entered vitamin D in the search engine and limited the search to that year.  There were over 2,100 papers.  I just did this for 2008 and there were over 2,300 papers.  If you limit it to the last ten years it comes up with over 17,000 papers.  The published recent work on vitamin D is voluminous.

The Vitamin D Council has provided a wonderful list of diseases that have been associated with vitamin D deficiency on their research page.  You go there, pick the disease and it sends you to PubMed right to the abstract of the article.  If you do not have a subscription to the particular journal you can purchase the article from the publisher online.

In reading this list, it makes me wonder why there are so many diseases and so much research and yet the medical profession is not treating with vitamin D.  There are so many diseases that are a result of or have a component related to D deficiency, you would think the news organizations would be all over this, but I digress.

If you are a doctor or a researcher and you are trying to just get a feel for the research that is out there then Dr. John Cannell has organized the research by disease.  It is a starting place as there are still many diseases that he has not listed.  For example, I had degenerative disc disease that is really a form of osteoarthritis.  This disease caused severe chronic pain, muscle wasting in my legs, central sleep apnea, memory loss from brain shrinkage with the pain, and other symptoms from oxygen deprivation from the sleep apnea.  If we took sleep apnea we find that it is not in the list because no one has done any research on it and vitamin D even though it has an obesity and stenosis vector which both can be tied directly to vitamin D deficiency.  There is a lot of work that is left to be done and a lot of miss-education of doctors, researchers, and the public in general that needs to be corrected.

Another disease that is not listed is psoriasis and I know that it can be treated with vitamin D according to Dr. Michael Holick of Boston University.  Dr. John Cannell has done a great job and we are grateful for his work, but the tentacles of vitamin D reach far and long in the course of human health and disease.

If you do not find the disease that you have interest with, then just go to PubMed and search on the disease itself and components of vitamin D.  Also I am sure that if you can identify research and that has not been listed then the Vitamin D Council would be interested.  Send that along to them.

Let’s just make a copy of the list without comment to see how long it is:

Vitamin D Council Research Links by Disease

Addison’s Disease
Allergic Hypersensitivity
Alzheimer’s Disease
Ankylosing Spondylitis
Asthma
Autism
Autoimmune Illness
Benign Prostatic Hyperplasia
Bladder Cancer
Brain Cancer
Breast Cancer
Cancer
Celiac Disease
Cerebral Palsy
Chronic Obstructive Pulmonary Disease (COPD)
Chronic Pain
Cognitive Function
Colon and Rectal Cancer
Cystic Fibrosis
Depression and Seasonal Affective Disorder
Diabetes
Endometrial Cancer
Epilepsy
Ethnicity and Vitamin D
Eye Cancer
GastrointestinalFunction
Gaucher’s and Fabry’s Disease
Vitamin D and Genetics
Graves’ Disease
Hashimoto’s Thyroiditis
Heart Disease
HIV and AIDS
Hypertension
Inflammatory Bowel Disease
Influenza
Innate and Adaptive Immunity
Liver Cancer
Liver Function
Lung Cancer
Lymphoid Cancer
Melanoma
Mental Illness
Mineral Metabolism
Multiple Sclerosis
Muscular Weakness and Falls
Obesity
Osteoarthritis
Osteomalacia
Osteopenia
Ovarian Cancer
Pancreatic Cancer
Parathyroid Function
Parkinson’s Disease
Pediatrics
Post menopause
Pregnancy and Lactation
Premenstrual Syndrome
Prostate Cancer
Renal Function
Rickets
Sarcoidosis
Sickle Cell Disease
Skin Cancer
Stroke
Toxicity
Toxin and Radiation Exposure
Tuberculosis
Turner’s Syndrome
Vitamin D Deficiency

Other items of interest for Vitamin D with links to the research:
Best Science
Commentaries and Editorials
Genetics
Requirements
Reviews
Treatment
UV Exposure
Veterinary and Animal Studies
Worst Studies

Vitamin D Council Research Links by Disease

Well, I hope that you find this useful and that you do not think that just because your disease of interest is not in this list that it does not have a vitamin D vector.  This seccosteroid is the most important steroid of the human body – Vitamin D3.

There is a lot of pain and death listed above.  Shine the light on this research!!!  – Pandemic Survivor

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Brigham and Woman’s Study on Vitamin D

Well it looks like the NIH is finally taking this vitamin D thing seriously.  Harvard Medical School and Brigham and Woman’s Hospital are to enroll 20,000 people in a study taking vitamin D3 at 2,000 IU per day and fish oil for omega three fats.  Twenty five percent of the people in the study are to be black.  You can read the AP article here.

I believe the level of supplementation is less than half of where it should be, but this is enough to start to see the effect on chronic disease.  The real issue is that it will take several years into the study to start to see that the nation as a whole should be supplementing.  The question for you is that if it does no harm why wait until the study is complete to get your serum level high enough to where it will do some good.

The serum level should definitely be above 40 ng/ml of 25(OH)D and to get the best effect in the body it should be above 70 ng/ml.  The NIH fact sheet (Table 1) says that harm does not start to occur until it is above 200 ng/ml and animal studies show that below 400 ng/ml is safe.  This gives you a safety factor of at least 3 which is much better than most any prescription drug.

The thing that is really troubling to me is that many of the participants will be given placebos with no vitamin D.  I will pray for these people that they do no die from this continued deficiency of this vital steroid.  Hopefully as positive results are shown that the placebo group will also be given vitamin D.

If you decide not to wait because you already have one of the many chronic diseases from vitamin D deficiency then do what it says on the Vitamin D Council home page.  The volume of research is already HUGE and why we need another study is beyond me.  We have already done this the first part of the 20th Century when everyone was taking 2 tablespoons of cod liver oil, about 2600 IU of D3, per day without harm.  The only issue was that the vitamin A level may have been too high in the cod liver oil.  Look at the volume of research by disease at this Vitamin D Council Research Page.

I have been reading extensively on roles of vitamin A and how it interacts with vitamin D.  How these two act in synergy is still not complete science, but I do feel much better when I eat liver or take about 4000 IU of vitamin A from fish liver oil.  I will blog about this in the near future.

Here are the many diseases:  17 varieties of cancer as well as heart disease, stroke, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle wasting, birth defects, periodontal disease, and more.

Why wait!?  It is your health and your life – be healthy!   The encouraging thing about this pandemic is that the news of vitamin D is moving very fast through word of mouth and blogs like this one.  We should start to see things like the overall rate of cancer start to reduce significantly as more people take it on themselves to supplement.

Go into the sun!!!  The best time is between 11AM and 2PM when the UVB radiation is at it highest.  Wear the least amount of clothes possible so that you do not get locked up and if you start to turn pink it is time to get out of the sun and wait until the next day.  As you start to tan it will take longer and only about 15 to 20 minutes to start depending on skin color will be long enough.  – Pandemic Survivor