Metadichol as Mediator of Inflammatory Response

Note to readers: This article is to notify researchers to the possibilities of Metadichol as a mediator of the AHR-Nrf2 pathway for inflammatory response. Metadichol’s action on nuclear receptors is hugely significant. The importance of Metadichol’s effect is in regulating inflammatory response to outside agents. Outside agents may include drugs, manmade toxins, or even response to light (think sunburn and/or retinal protection). In this paper, it is shown how Metadichol may be significant in treating chemo resistant cancer.

Metadichol ®. A Novel Inverse Agonist of Aryl Hydrocarbon Receptor (AHR) and NRF2 Inhibitor
Journal of Cancer Science and Therapy 

Raghavan, P R
Nanorx Inc., Chappaqua, New York, USA,  

Abstract
Metadichol ® a novel nano-emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2)) and is a transcription factor that is ubiquitously expressed at low levels in all human organs and regulates a primary cellular defense mechanism, tight regulation to maintain cellular homeostasis. AHR is highly expressed in a broad panel of tumors, AHR is induced by 2,3,7,8-tetrachloride-benzo-p-dioxin (TCDD) Metadichol® as a inverse agonist against AHR could be potentially useful in the treatment of such diseases. Strong in vivo evidence suggests that TCDD can stimulate cross-talk between AHR and Nrf2. The constitutive up regulation of Nrf2 signaling appears to drive the cellular proliferation and resistance to chemotherapy in various cancers. Therefore, pharmacological inhibition of Nrf2 by Metadichol ® holds promise as a therapeutic strategy in chemo resistant forms of cancer. 

Here is a link to the PDF: metadichol-AHR-Paper

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Terror at the VA

VA HealthThirty months at war in Vietnam. Twenty-three years in the military. The horror of war imprinted in your brain to be replayed at any time. Triggered by almost any incidence, it comes at you like the ballistics at the end of a twelve-inch gun. Emotional trauma so strong the only place you can cope is in the structure of the military. How would you expect to be treated after decades of service protecting your country? You would like to think that our veterans are treated with great dignity and the respect they deserve.

We often hear horror tales of how our veterans are treated by VA Hospitals and healthcare in general. It usually involves waiting times. Recently there was the story of the nurse who was so occupied with a game she let a heart patient die on her watch. I have passed this off as local occasional incidents no different than our accepted medical treatment, but the problem is much more widespread. I got permission from my brother to tell his story of malpractice the VA. He gave me permission if I stick to the facts. I have waited three years to relay this story as he does not want to be bothered with legal action against a country that he fought to protect. Unfortunately, this is not a made-up Halloween story to just horrify you.

It was getting late at night and the pain continued to grow in Brother’s abdomen and radiating to his back. What has happened now? Bad food that has turned his gut up-side-down? Brother decided to return to Fayetteville, NC to make a life for himself after his service. He was never married as he did not want to burden another with emotional trauma delivered by military life. Only supported by a few friends and family members that did not forget him after three decades intermittent contact, he considered Fayetteville a safe-haven because of its military nature. Brother’s temperature had continued to increase over the last hour from 101 to 103. He called his friend Buddy to take him to VAMC emergency department.

After medical personnel had examined him at the emergency room, Brother was told that the pain was coming from a hip that was damaged from combat and military life. He was told to go home, take two aspirin for his temperature, and he would be just fine. Brother knew this was wrong. When you are deathly sick, signals alarm in your body that cannot be ignored. He pleaded with the medical personnel that something was deadly wrong, but they passed him off like a fly had lit on their ham sandwich.

Brother instructed Buddy to take him to Womack Army Medical Center (WAMC) on the Fort Bragg military complex. After emergency medical personnel examined him, he was immediately catharized. He had kidney stones blocking his bladder. The pain in his abdomen was from a swollen bladder that was about to rupture. His temperature spike was determined to be coming from a kidney and urinary infection. After further examination, it was determined that he had pyelonephritis. This deadly disease can kill you within hours or days as the bacteria spreads into your blood stream. He was put on IV antibiotic and kept in the hospital for over a week. Later x-rays showed that he had multiple kidney stones that needed to be removed from his kidney.

If Brother had complied with VAMC emergency, I would now be visiting his grave. Are directions coming from the top that former soldiers are to be managed in a way that fits a budget? Managed in a way that soldiers nearing late-life increases in benefits should be allowed to die to control cost? Is the VA in Fayetteville over-burdened with too many returning soldiers? Are government unions protecting employees to the point that incompetence has become a way of life? Whatever happened to duty, honor, country—General MacArthur is shuddering in disgust. President Donald J. Trump, clean up this cesspool! 

(In research for this article, I found this notice from September 2014 or the period when Brother’s emergency occurred. Get with it Elizabeth Goolsby, Medical Center Director, you’ve got to be better than this. If you are a veteran living in Fayetteville, do not use the VAMC.) –Mark Pegram contact: vitamindmark at gmail 

Artful Addiction—Sugar, Flour, Insulin, Leptin

Leptin Insulin CartoonThe issue is that modern medicine does not determine if you are nutrient deficient.  Modern medicine is more interested in using drugs to give immediate relief and not the long-term solution of healing. And then, the side effects of the drugs kill you. The need for drugs must be driven by a large market of ill people. The sugar addiction/fat elimination has provided this opportunity.

When I was growing up on the farm, I used to eat five to eight thousand calories per day.  This was necessary for the long arduous hours spent in labor.  Most days were sixteen-hour days. With this high intake of calories, imagine the amount of nutrients that I was getting.  Of course, there was not any processed food.  It all came from our efforts in the garden, pasture, hunting, and fishing. Even the bread we ate came from the wheat that was grown on our farm. Our cash crop was tobacco, but my parents were smart enough to forbid us from using it.  In a sense, we were just like modern medicine in not embracing what gives us health. Instead, we embraced a healthy farm economy. America was founded on the income of tobacco and alcohol. (This link is an interesting story about the interaction of my family, over several generations, with alcohol. Published at the Dead Mule School of Southern Literature.)

In my ten thousand-or-so hours of research, I have found that we are all deficient in most minerals and vitamins. I, like Linus Pauling and Hippocrates (a couple of millenniums of understanding), have concluded that all chronic disease comes from nutrient deficiencies.  The number one chronic disease in the US is obesity. I am fat as a hog raised on molasses feed just waiting for the slaughter.  I’m am addicted to the evil of processed sugar in its many forms.  We have created this epidemic of chronic obesity though our efforts in reducing fat.  I don’t believe that the researchers thought fat was bad for us. I believe that the money derived from a sick population was very addictive. It takes a large sick population to have twenty percent of its gross domestic product to be from medicine.  (Simple explanation of how increased sugar intake produces more insulin which blocks leptin and causes us to eat too much by Dr. Robert Lustig, UCtv.)

We have recently discovered that insulin increase blocks our hey-we-are-full hormone, leptin.  We have found that eating any dense carbs and sugar increases appetite. How long have we known this bit of extremely important information for our health? Leptin suppression was useful when we were hunters and gatherers as we gained weight that allowed us to live through the lean times. The Inuit tribes knew best as their major calorie source was fat. Linus Pauling in the 1970s with his studies of prisoners (complete control of food source) knew that fat did not increase cholesterol, that sugar was the primary reason for the increase. 

Even though I’m a fat hog, my health is great. I did one of those test for actual age and came out at mid-thirties. Not bad for a sixty-six-year-old. It is all the vitamins and minerals that I use through supplementation. Now that I understand the insulin/leptin response, the avoidance of sugar and flour are prime in my diet.  However, this elimination of an addiction is going to be difficult.  I just recently went on the Whole30 diet and lost twelve pounds in a month. My body functioned just fine without addictive items.  In this diet, you eliminate grains, alcohol, dairy, and legumes for thirty days. I discovered that I was lactose intolerant during the trial. How many addictions and allergies do you have?  Stay tuned as I begin the journey of a healthy diet. –Pandemic Survivor (Can I escape the obesity epidemic? Present BMI 29.5 – 6-2, 230)