Pathogen Uses of Cloaking Devices Disrupted

Pathogen CloakingIn the much-watched Star Trek program, the dastardly Klingons would cloak their ships so that they were invisible to the USS Enterprise. In the human body, pathogens also cloak themselves to be invisible, seem like sugar or a food, by using sialic acids. Sialic acids are common on the cells of vertebrates and are the highest concentration in the brain. The immune system will not attack pathogens with sialic acid attached because they appear as a natural part of the human system. Dr. P. R. Raghavan has found that Metadichol, by expressing the CD33 gene, allows binding of these acids so that the immune system can disrupt the pathogen.
There have been many papers published on human healing by Dr. Raghavan that include increase in stem cells, reduction of diabetes, and general well being realized with the use of Metadichol. The finding of the binding of sialic acid with the expression of CD33 and the increase in stem cells explains the healing of wounds quickly when using Metadichol.
Below is a recently published paper by Dr. Raghavan on this topic. Metadichol acts to up regulate or down regulate CD33 depending on signaling mechanisms in human physiology.

Metadichol® and CD33 Expression in Umbilical Cord Cells

Abstract
CD33 also known as Siglec-3 is endogenously expressed in stem cells and is a marker for the myeloid lineage of cells. Increased expression of CD33 thus allows it to bind to any Sialic Acids (SIAs). These acids are binding sites for pathogens and toxins. By binding to these acids, CD33 can prevent invasion of hosts by these pathogens. Down-regulation of CD33, increase the release of the pro-inflammatory cytokine TNF-α by monocytes that increases reactive oxygen species that are involved in diseases like diabetes mellitus, Alzheimer’s, cardiovascular diseases asthma, and in various cancers.
     The up-regulation of CD33 using Metadichol® was studied using Wharton’s Jelly Mesenchymal Stem Cells (MSCs) isolated from human umbilical cord and were grown in p-35 dishes until confluent and treatment was carried out with different concentrations. One dish was untreated and considered as control. The treated and untreated cells were analyzed using Flow Cytometry. The cells treated at 100 pg of Metadichol® has shown the highest increase (>400 fold) in CD33++ expression (48.77%) compared to untreated control (0.11%).
Link to paper: CD33-paper
This paper may be difficult to digest. However, that should not stop you from using Metadichol for whatever ails you. This is a link for the 29 articles with links to Dr. Raghavan’s papers that I have published on Metadichol.  –Mark Pegram

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Vitamin D Treats Liver Disease

Liver PicVitamin D does treat liver disease. Way back in December 2009, I wrote about how vitamin D had brought myself and one other family member’s liver markers into the normal range. This included a problem with hepatitis—Hepatitis C Cured? By now I have had many tell me that taking vitamin D had cleared up their liver. The commercial that we are constantly bombarded with on TV about you don’t have to have Hep C anymore is a drug that is most likely just a vitamin D mimic or analogue (A manmade molecule or compound that is similar to the natural molecule.).

The Vitamin D Council, Dr. Cannell, has ranted on about how vitamin A is destructive to the level of vitamin D. Strictly speaking this is true. He even had a disagreement with the Weston Price Foundation about the need for vitamin A. Cannell’s contention was that vitamin A build-up in the liver was the cause of chronic liver disease. The truth, vitamin D and vitamin A form a dimer in some of the most important functions in the body. If you are getting enough vitamin D, your liver clears of vitamin A. The important functions that I can think of immediately are cellular differentiation and stimulating the immune system, specifically the start of increasing antimicrobial peptides that are your body’s natural pathogen killer cells. After several months of supplementing with vitamin D, I had to also supplement with vitamin A, retinol palmitate, for the effectiveness of vitamin D. Until trials are run with the combination of vitamin D and vitamin A, there will continue to be confusion over the effectiveness of fat-soluble vitamins. Our forebears were absolutely correct in their supplementation with cod liver oil.

It is the combination of vitamin D and vitamin A that is critical to your health. Our fathers of medicine have long ranted about the dangers of fat-soluble vitamins. The primary reason for this is not a lack of understanding, but the need to sell you pharmaceutical analogues. Eat large amounts of beta carotene as that is not dangerous was the mantra. The truth is that large amounts of beta carotene can be very dangerous to the lungs. The liver does not convert beta carotene until you are already deficient in vitamin A. The manufacturers of vitamins have reduced the amount of beta carotene that was in multivitamins.

Now with nutraceuticals that are available, we can have our cake and eat it too. Dr. P. R. Raghavan has created the nutraceutical Metadichol. This works to bring the body to homeostasis. It works along many pathways included genetic expression and control of the molecular receptors. What is Metadichol and why is it so effective in treating disease and healing wounds? Metadichol is made of policosanol that is commonly found on all plants. The problem in modern nutrition is that we take away the part of the plant where the concentration of the policosanol is the highest. The advantage of Metadichol is it is made by making a small particle emulsion. We did some of this on our own when we used to chew the husk from food. Now, we have the opportunity to assure that we are getting enough policosanol for health. Taking policosanol as a supplement is not the same as the small particle emulsion. Dr. Raghavan has published over ten papers on the matter and is going around the world to lecture and help other researchers understand the importance of the small particle emulsion of policosanol. Metadichol is very important in how it puts the vitamin D receptor into the state that is required for health. The vitamin D receptor is like the conductor of an orchestra in the smooth harmonies of all receptors. Here is a recently published article on how Metadichol is significant for liver disease.

“A Multi Gene Targeting Approach to Treating Liver Diseases with Metadichol®”

Abstract

Liver diseases are becoming a major health concern. In the developing countries it is due to microbial infection. In the rest of the developed world it is due to alcohol abuse. Chronic liver disease and cirrhosis are a significant health concern in western countries. It is the fifth most common cause of death, after heart disease, cancer, stroke, and chest disease. The liver is capable of regeneration, but it can be overwhelmed leading to liver diseases like cirrhosis and hepatocellular cancer (HCC).

Vitamin D levels are low in most patients with liver diseases, and this suggests possible therapeutic benefits with use of vitamin D or its analogues. Vitamin D, through the vitamin D nuclear receptor (VDR) plays a crucial role in mineral ion homeostasis. The liver has a central role in vitamin D synthesis and there is a need for an agent that will not lead to hypercalcemia. Metadichol, a nano-emulsion of long-chain alcohols derived from food, is an inverse agonist of Vitamin D can fill this void.

In Diabetic rat studies, it inhibits TNF alpha, ICAM1 (intracellular adhesion molecule), CCL2 (chemokine C-C motif) also referred to as monocyte chemoattractant protein 1 (MCP1). All these cytokines, chemokines are known to have important role in liver diseases. We show that Metadichol indeed does work in liver disease patients by normalizing essential liver enzymes ALT, AST and ALP, and GGT. This approach is an example where Metadichol targets multiple genes and via multiple pathways to bring about homeostasis of the liver and is a useful, safe, nontoxic product in treating liver diseases and alleviating a global threat.

Link to published paper: Liver-disease-paper (1)

Mark Pegram

Please note that I have not been writing due to the long-term illness and recent death of my brother from agent orange exposure during his thirty months at war in Vietnam. The mutation of his genes from the dioxin exposure prevented his physiology from reacting normally to modern medicine and nutrition. Interestingly, the doctors and researchers in my family have agreed to this. War and the aftermath is hell.

The Fountain of Youth, Metadichol?

INSERT CLOTHOClotho is one of the three Greek fates that are responsible for the thread of life in Greek mythology. Clotho is known as the spinner of the thread while the others draw out and cut. In our understanding of physiology, we have named the gene responsible for reduced chronic disease—Klotho. The up regulation of klotho appears to significantly reduce chronic disease. A few to consider are cancer, diabetes, rheumatoid arthritis, and coronary artery disease. Have we stumbled unto the gene that is responsible for the fountain of youth?

The klotho gene appears to be regulated by constituents of the vitamin D family, especially the vitamin D nuclear receptor (VDR). In the past, DR. P. R. Raghavan has shown that Metadichol acts to regulate VDR. In the paper, “Metadichol a Novel Agonist of the Anti-aging Klotho Gene in Cancer Cell Lines,” it is shown how Metadichol up regulates klotho in pancreatic cancer cells by as much as ten-fold against controls. Here is the link to the paper: METADIHCOL-KLOTHO

Here is the paper abstract:

Abstract

Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of life. Klotho is a transmembrane protein known to be a co-receptor for Fibroblast Growth Factor-23. Klotho gene is expressed in a variety of tissues changes in the levels are associated with many diseases. Klotho is a tumor suppressor in breast cancer and its expression is reduced in human pancreatic adenocarcinoma, and treatment with klotho inhibits the growth of pancreatic cancer cells in vitro and in vivo.

Growing evidence suggests that an increase in Klotho (KL) expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. It remains a challenge today to induce Klotho expression. Herein we show that treating pancreatic cancer cells PANC1, MIAPACA and COLO-205 with Metadichol® a novel food-based lipid emulsion of long chain alcohols at picogram/ml, concentration led to a 4 to10 fold increase in Klotho expression as seen quantitative RT-PCR. These results suggest the use of Metadichol® given its constituents that are present in foods we consume every day is a novel therapeutic intervention for pancreatic cancer and other diseases.

The importance of vitamin D and common food compounds like the long chain alcohol lipids that comprise Metadichol is once again shown. We did not have to spend years in Florida looking for the fountain of youth. I bet Ponce de Leon would be very jealous. –Pandemic Survivor.

Metadichol and Glucose Transport

Once again Dr. P. R. Raghavan has demonstrated how Metadichol works to improve health. In a recent paper, published in the Journal of Stem Cell Research & Therapy, Metadichol is shown to affect the glucose transporter 4 (Glut4 – found primarily on muscle cells) and associated receptor substrates. This explains the control of glucose in patients treated with Metadichol in many case studies.  “Umbilical Cord Treatment with Metadichol, IRS and Glut4 Expressions and Implications for Diabetes” Link to Paper as PDF: IRS-GLUT4-PAPER

It is important to understand that this is a new paradigm for treatment of disease. Typically, in medical treatment research, it has been “one drug–one target.” In the above paper, it is shown how a new understanding of treatment is obtain with “one drug–multiple targets.”  When gene expression as well as nuclear receptors are brought into proper communication, amazing things happen.

Glucose transporters have been shown to increase the transfer of sugars through cell membranes in several ways. Of course, insulation regulation has always been the obvious control of sugar uptake by cells. It is also well known that exercise significantly increases the action of Glut4 which is the transporter for muscle cells. In addition, thyroid hormones play an important role in glucose transporters (which means that iodine and selenium are important). Now for the first time, the regulation of glucose transporters is shown to be affected by a food substance.

Metadichol is a nano-emulsion of waxy aliphatic alcohols, policosanols. The difference of Metadichol and other policosanol supplements is the small particle formulation. Policosanols can be found in many plants. Modern processing of foods has significantly changed the way our bodies take up policosanols. The most concentrated areas of policosanol are on the surface of leaves and husk of seeds and grains.

This is exciting news for diabetics who may be able to control their blood sugar with a substance that does not have side effects, Metadichol. 

 

References:

Glucose Transporters–Wikipedia

Signaling Mechanisms that Regulate Glucose Transport

Glut4–Wikipedia

Glucose Transport Pathway

Metadichol Paper for Skin Repair

In February, I posted about the effectiveness of Metadichol for skin repair.  You can find that article here. It is amazing how it healed my skin without forming a scab. The healing occurred very quickly. Dr. P R Raghavan has published a new paper about skin. “Metadichol® and Healthy Skin: One Approach Many Possible Cures.”  It is published in the Journal of Clinical & Experimental Dermatology Research: Raghavan, J Clin Exp Dermatol Res 2018, 9:1.  Here is a link to the paper-PDF:Metadichol-Skin-applications

From the Abstract
Metadichol is the first molecule to successfully navigate around the problems involved with promiscuous ligands and targets. It fulfills the goals of the emerging field of Polypharmacology i.e a single drug is able to bind to multiple targets beyond the “one drug, one target” concept. We show how Metadichol is an innovative treatment for treating multiple skin diseases like eczema, acne, diabetic wounds viral and bacterial infection and improving skin texture. Metadichol ® is a safe nontoxic low-cost solution and is an alternative to numerous clinical candidates in combating over 3,000 skin diseases.

Don’t let the science of the paper prevent you from accessing the paper. It shows many pictures of skin disease from baseline to healing.  These are amazing pictures and well worth the time to review. In the paper, Dr. Raghavan describes the many drugs that are currently being used to heal skin. These drugs are designed for one drug, one target. Dr. Raghavan shows how Metadichol binds to multiple targets using links-and-connections diagrams. This action of binding to many targets explains how Metadichol acts to provide quick healing. With about 3,000 skin diseases, it is astounding how one compound can heal multiple diseases

Here are a couple of pictures of my own healing from the February post, article here.  I just don’t have the words to express my delight in how Metadichol works. Here are the many articles that I have posted on Metadichol.

Sep 20A1cSep 27A1c

Metadichol and Skin Repair

In last post, we discussed the advantages of Metadichol in stem cell development. I suspected several years ago that somehow Metadichol works differently to aid in the repair of skin tissue. In this article, I will show two examples from my own experience with skin repair.

Case 1–A cut from walking in the woods

I took a walk through some very thick woods in September 2016. I received a cut on each arm from snags in the woods. The long cut was bleeding badly. Remembering that policosanol is on most sun-splashed portions of plants, I chewed up some white oak leaves and placed the chewed leaves on the cut. The bleeding stopped almost immediately. I’m not sure why the chewed leaves stopped the bleeding. It was something that we did as children on the farm. I knew that it would work. 

Sep 20A1cHere is a picture of the cut the next day. As you can see it had started to heal. I had treated it with Metadichol spray when I got home that night.

I continued to treat it once a day, and here is the result after seven days. As you can see in the photo, the cut is very nearly healed. There was no soreness during the treatment period. It is interesting to note that no scab formed on the cut. Sep 27A1c

Since I had a cut on the other arm that was not as significant, I decided to treat it with triple antibiotic ointment. I treated it with the ointment on the night that I came home. Here is a picture on the next day. Sep 20B1c

I continued to treat it once a day with the triple antibiotic ointment. Sep 27B1cThere was significant soreness that continued throughout the seven days. Here is a picture of the result. As you can see, the scab is still in place, and there is some healing. I started treating it with Metadichol, and it healed in several days. 

Case 2–A burn wound that was not healing

August 28A friend of mine contacted me in August 2015 to say that she had a burn on her finger that was not healing.Sep 3 I am not sure how long it had been since she had the burn. She said she had been to a doctor, and he gave her a steroid ointment. I gave her a bottle of the Metadichol and suggested that she spray the wound with one spray twice per day.  She said she no longer used the steroid ointment.

Sep 7Here are pictures of the wound from day one, day six, and day ten. It is amazing how the wound progressed to healing from day six to day ten. She called me to ask if she should break the blister on day six. I told her that I did not think that was a good idea. The day ten photo speaks to the accuracy of this suggestion.

As you can see, my experience with using Metadichol for skin repair is significant. –Pandemic Survivor

Enhanced Development of Stem Cells with Metadichol

3D Stem CellsMy first experience with Metadichol was the quick healing of a wound. A wild cherry tree had fallen in the woods behind my house. I had sawed the tree into fire size logs and stacked them in a pile. As I threw one of the logs onto the pile, it caught the back of my hand and caused a two-inch-long cut. I treated the cut with the Metadichol spray. The healing took place twice as fast as my normal experience with cuts. I suspected then that somehow stem cells must have been increased or differentiated or both by the Metadichol for the quick healing (A future article will show two examples of healing with Metadichol from my personal experience.) Dr. P. R. Raghavan has had research done by Skanda Labs to show that stem cells are increased in umbilical cord blood when treated with Metadichol.

The research paper, Metadichol and CD34 Expression in Umbilical Cord Blood, is published in the Journal of Stem Cell Research & Therapy on January 29, 2018. CD34 is a marker for the action of stem cells in many types of cells within the body. During the study, an increase of CD34 protein was shown with the application of Metadichol. Injection of CD34 enriched hematopoietic stem cells have been clinically used for treating spinal cord injury, cirrhosis and peripheral vascular disease. Link to paper as PDF: Metadichol-CD34

There are many types of stem cells within human biology. The two basic classes are embryonic stem cells and adult stem cells. The ability of Metadichol to enhance the development of and the differentiation into a variety cells is critical to healing. This may mean that Metadichol can be used in many different cases of disease to promote healing. Metadichol is simply a nanoemulsion of policosanol or a food substance. Policosanol is a waxy alcohol that is found of many plants which we use for food. There are no known side effects with the food, policosanol.

Science is now using genetic manipulation to help in the development of stems cells. The result is the possibility of rejection of the developed cells and serious side effects. Destruction of cells in the attempts to heal cancer has required the replacement of healthy cells. This has been done typically by using the person’s cells and genetically manipulating them and replacing them in the body. Earlier and current attempts in replacing cells have been done through transplants from donors as in bone marrow transplants. Also, cord blood is now being frozen by some for future use in healing because of the concentration of stem cells.

This is very exciting news. The development of a natural substance used for healing confirms the fact that “Food is medicine and medicine is food.” Thanks for reading. –Mark Pegram

Other Post (22) on Metadichol: https://pandemicsurvivor.com/category/metadichol/

Resources and Useful Links:
http://learn.genetics.utah.edu/content/stemcells/scintro/
https://www.eurostemcell.org/cord-blood-stem-cells-current-uses-and-future-challenges
https://www.scientificamerican.com/article/for-which-diseases-or-con/
https://www.viacord.com/treatments-and-research/treatable-diseases-today/