Metadichol® Case Studies for Thyroid Disease

Thyroid DisordersMetadichol has shown that it is effective in treating many maladies. It is not a drug with one target. It is a food substance that acts on many targets including genetic expression and controlling nuclear receptors. Metadichol is a nanoemulsion of long chain alcohols that are commonly found on most plants. We have lost access to this vital nutrient because of processing foods.

The paper presented shows many case studies with thyroid disorders. Metadichol acts on many of the nuclear receptors that are necessary for a healthy thyroid. This is for both hypothyroidism and hyperthyroidism. Again, Metadichol acts on multiple targets for the thyroid and other physiology to bring the body to homeostasis.

Metadichol® A Novel Inverse Agonist of Thyroid Receptor and its Applications in Thyroid Diseases


     An estimated 200 million individuals worldwide have a thyroid disorder. Thyroid diseases affect seven times more women than men. People not diagnosed make up the majority of thyroid patients. There is a need to find novel and safe ways to change the underlying disease processes, rather than merely stop excess thyroid hormone production as in hyperthyroidism.
     Metadichol® is a nano emulsion of an extract of long-chain alcohols from food that is an inverse agonist of VDR (Vitamin D receptor), AHR (Aryl Hydrocarbon Receptor), and RORC (RAR Related Orphan Receptor C). The work presented here shows that Metadichol® is an inverse agonist of THRA (Thyroid Receptor Alpha) and THRB (Thyroid Receptor Beta). Case studies are presented that show how it can safely treat a multitude of thyroid related diseases. Network and pathway enrichment studies are presented that show how Metadichol® may be involved in action on multiple receptors and exerting its effects through multiple pathways. Metadichol® is the first of a breed of molecules that moves the goal post from the concept of ‘one drug, one target’ toward simultaneously targeting multiple targets, that can potentially lead to successful treatment of many diseases. Given the safety profile of Metadichol®, it would not only mitigate thyroid disease but prevent it and reducing the burden on healthcare budgets worldwide.

Link to paper:Metadichol-Thyroid-paper

Unfortunately, the paper does not discuss iodine deficiency which is the underlaying problem with the thyroid. The other issue is that there may also be a selenium deficiency. Selenium is necessary to convert T4 to T3 at the cellular level. Suggest that you read the work of Dr. David Brownstein, an endocrinologist and an expert in the thyroid and other iodine deficiency diseases.

Also, vitamin D3 deficiency is responsible for most autoimmune diseases. Be sure that you test your 25(OH)D3 levels. The level, if you are in a disease state, should be high normal in the normal range of 30 to 100 ng/ml (suggest 80 +/- 10 ng/ml). –Mark Pegram


A Breakthrough in Health and Extending Life Expectancy

TelemeresMetadichol® strikes again by improving the quality of life, eliminating disease, and extending life expectancy. This plant-based substance or food has shown many ways that it acts to reduce disease and improve health in general. Now the developer, Dr. P. R. Raghavan of Nanorx, Inc., has shown that it increases telomerase or the enzyme for maintaining and increasing the length of telomeres. From the press release: Aging is a law of nature and unavoidable. Instead of targeting a multitude of diseases that confront us as we age Metadichol® is about correcting the root cause of disease.

Telomeres are proteins that are at the ends of each chromosome to prevent the chromosome from sticking to other chromosomes and to protect the genes inside by keeping the chromosome from unraveling. The best way to think about how telomeres act is to imagine the end of a shoe string. How many times have you had the plastic protector on the end of the shoe string come off, and the shoe string begin to fray and unravel? The telomeres also act, during the duplication process of RNA/DNA, as a shield to prevent mishaps.

It has been shown that there are a limited number of reproduction of cells as each time the reproduction occurs, the length of the telomeres is reduced. In other words, the length of your telomeres is an indication of life expectancy. As you age, the telomeres shorten and allow the opportunity for chronic disease, like cancer. By increasing the amount of telomerase, the enzyme that keeps telomeres healthy, Metadichol® acts to improve health and extend life.

From a recent paper: The Quest for Immortality: Introducing Metadichol®, A Novel Telomerase Activator, Journal of Stem Cell Research and Therapy.
Link to paper: Telomerase-paper

Humans are keenly aware of their mortality. Given a limited time what we do with our life is a reflection of knowledge of our mortality. In 2009 the Nobel prize in medicine to Jack W Szostak, Elizabeth Blackburn, and Carol W Greider for their work on Telomerase and scientific research exploded in this area. Telomere protect chromosome ends and the Telomerase enzyme maintains Telomere length. This activity of Telomerase is essential in aging and stem cells and achieving longer life spans.
    Telomerase is expressed in 85% of human cancer cell lines, but its enzymatic activity is not detectable in most human somatic cells which constitute the vast majority of the cells in the human body. There is a need for increased telomerase activity in stem cells for use in the treatment of therapies where there is an active role for telomerase. Umbilical Cord Blood (UCB) provides an attractive source of stem cells for research and therapeutic uses. Work shown here characterizes the gene expression changes from Umbilical cord cells differentiate toward telomerase on treatment with Metadichol®.
     Metadichol® is a nanoemulsion of long-chain alcohols that is nontoxic. It is a mixture of long-chain alcohols derived from food. The work presented here is about the effect of Metadichol® on Telomerase expression profile in Umbilical cord cells. Our results using q-RT-PCR show increases of mRNA telomerase expression by Sixteen-fold at one picogram but down-regulates expression at higher concentrations of 100 pg, 1 ng, 100 ng and one microgram per ml concentration. Western blot studies showed expression of Telomerase protein which is slightly higher than control at one picogram, i.e., Telomerase protein expression continues at replacement level. Since it is devoid of toxic effects, it can be directly tested on humans and is in use today as an immune boosting supplement. Metadichol® increases expression of Klotho an anti-aging gene expression in cancer cell lines by Four to Ten-fold, and Klotho gene has been documented to inhibits the growth of cancer cells. Metadichol® also inhibits TNF, ICAM1, CCL2, and BCAT1 which that is associated with proliferation in yeast and increased metastatic potential in human cancers. It paves the way for safe clinical testing and research and study of Telomerase biology and its use in humans. 

The brilliance of Metadichol is that it is a food and has no known side effects—what a great nutraceutical. –by Mark Pegram

Pathogen Uses of Cloaking Devices Disrupted

Pathogen CloakingIn the much-watched Star Trek program, the dastardly Klingons would cloak their ships so that they were invisible to the USS Enterprise. In the human body, pathogens also cloak themselves to be invisible, seem like sugar or a food, by using sialic acids. Sialic acids are common on the cells of vertebrates and are the highest concentration in the brain. The immune system will not attack pathogens with sialic acid attached because they appear as a natural part of the human system. Dr. P. R. Raghavan has found that Metadichol, by expressing the CD33 gene, allows binding of these acids so that the immune system can disrupt the pathogen.
There have been many papers published on human healing by Dr. Raghavan that include increase in stem cells, reduction of diabetes, and general well being realized with the use of Metadichol. The finding of the binding of sialic acid with the expression of CD33 and the increase in stem cells explains the healing of wounds quickly when using Metadichol.
Below is a recently published paper by Dr. Raghavan on this topic. Metadichol acts to up regulate or down regulate CD33 depending on signaling mechanisms in human physiology.

Metadichol® and CD33 Expression in Umbilical Cord Cells

CD33 also known as Siglec-3 is endogenously expressed in stem cells and is a marker for the myeloid lineage of cells. Increased expression of CD33 thus allows it to bind to any Sialic Acids (SIAs). These acids are binding sites for pathogens and toxins. By binding to these acids, CD33 can prevent invasion of hosts by these pathogens. Down-regulation of CD33, increase the release of the pro-inflammatory cytokine TNF-α by monocytes that increases reactive oxygen species that are involved in diseases like diabetes mellitus, Alzheimer’s, cardiovascular diseases asthma, and in various cancers.
     The up-regulation of CD33 using Metadichol® was studied using Wharton’s Jelly Mesenchymal Stem Cells (MSCs) isolated from human umbilical cord and were grown in p-35 dishes until confluent and treatment was carried out with different concentrations. One dish was untreated and considered as control. The treated and untreated cells were analyzed using Flow Cytometry. The cells treated at 100 pg of Metadichol® has shown the highest increase (>400 fold) in CD33++ expression (48.77%) compared to untreated control (0.11%).
Link to paper: CD33-paper
This paper may be difficult to digest. However, that should not stop you from using Metadichol for whatever ails you. This is a link for the 29 articles with links to Dr. Raghavan’s papers that I have published on Metadichol.  –Mark Pegram

Vitamin D Treats Liver Disease

Liver PicVitamin D does treat liver disease. Way back in December 2009, I wrote about how vitamin D had brought myself and one other family member’s liver markers into the normal range. This included a problem with hepatitis—Hepatitis C Cured? By now I have had many tell me that taking vitamin D had cleared up their liver. The commercial that we are constantly bombarded with on TV about you don’t have to have Hep C anymore is a drug that is most likely just a vitamin D mimic or analogue (A manmade molecule or compound that is similar to the natural molecule.).

The Vitamin D Council, Dr. Cannell, has ranted on about how vitamin A is destructive to the level of vitamin D. Strictly speaking this is true. He even had a disagreement with the Weston Price Foundation about the need for vitamin A. Cannell’s contention was that vitamin A build-up in the liver was the cause of chronic liver disease. The truth, vitamin D and vitamin A form a dimer in some of the most important functions in the body. If you are getting enough vitamin D, your liver clears of vitamin A. The important functions that I can think of immediately are cellular differentiation and stimulating the immune system, specifically the start of increasing antimicrobial peptides that are your body’s natural pathogen killer cells. After several months of supplementing with vitamin D, I had to also supplement with vitamin A, retinol palmitate, for the effectiveness of vitamin D. Until trials are run with the combination of vitamin D and vitamin A, there will continue to be confusion over the effectiveness of fat-soluble vitamins. Our forebears were absolutely correct in their supplementation with cod liver oil.

It is the combination of vitamin D and vitamin A that is critical to your health. Our fathers of medicine have long ranted about the dangers of fat-soluble vitamins. The primary reason for this is not a lack of understanding, but the need to sell you pharmaceutical analogues. Eat large amounts of beta carotene as that is not dangerous was the mantra. The truth is that large amounts of beta carotene can be very dangerous to the lungs. The liver does not convert beta carotene until you are already deficient in vitamin A. The manufacturers of vitamins have reduced the amount of beta carotene that was in multivitamins.

Now with nutraceuticals that are available, we can have our cake and eat it too. Dr. P. R. Raghavan has created the nutraceutical Metadichol. This works to bring the body to homeostasis. It works along many pathways included genetic expression and control of the molecular receptors. What is Metadichol and why is it so effective in treating disease and healing wounds? Metadichol is made of policosanol that is commonly found on all plants. The problem in modern nutrition is that we take away the part of the plant where the concentration of the policosanol is the highest. The advantage of Metadichol is it is made by making a small particle emulsion. We did some of this on our own when we used to chew the husk from food. Now, we have the opportunity to assure that we are getting enough policosanol for health. Taking policosanol as a supplement is not the same as the small particle emulsion. Dr. Raghavan has published over ten papers on the matter and is going around the world to lecture and help other researchers understand the importance of the small particle emulsion of policosanol. Metadichol is very important in how it puts the vitamin D receptor into the state that is required for health. The vitamin D receptor is like the conductor of an orchestra in the smooth harmonies of all receptors. Here is a recently published article on how Metadichol is significant for liver disease.

“A Multi Gene Targeting Approach to Treating Liver Diseases with Metadichol®”


Liver diseases are becoming a major health concern. In the developing countries it is due to microbial infection. In the rest of the developed world it is due to alcohol abuse. Chronic liver disease and cirrhosis are a significant health concern in western countries. It is the fifth most common cause of death, after heart disease, cancer, stroke, and chest disease. The liver is capable of regeneration, but it can be overwhelmed leading to liver diseases like cirrhosis and hepatocellular cancer (HCC).

Vitamin D levels are low in most patients with liver diseases, and this suggests possible therapeutic benefits with use of vitamin D or its analogues. Vitamin D, through the vitamin D nuclear receptor (VDR) plays a crucial role in mineral ion homeostasis. The liver has a central role in vitamin D synthesis and there is a need for an agent that will not lead to hypercalcemia. Metadichol, a nano-emulsion of long-chain alcohols derived from food, is an inverse agonist of Vitamin D can fill this void.

In Diabetic rat studies, it inhibits TNF alpha, ICAM1 (intracellular adhesion molecule), CCL2 (chemokine C-C motif) also referred to as monocyte chemoattractant protein 1 (MCP1). All these cytokines, chemokines are known to have important role in liver diseases. We show that Metadichol indeed does work in liver disease patients by normalizing essential liver enzymes ALT, AST and ALP, and GGT. This approach is an example where Metadichol targets multiple genes and via multiple pathways to bring about homeostasis of the liver and is a useful, safe, nontoxic product in treating liver diseases and alleviating a global threat.

Link to published paper: Liver-disease-paper (1)

Mark Pegram

Please note that I have not been writing due to the long-term illness and recent death of my brother from agent orange exposure during his thirty months at war in Vietnam. The mutation of his genes from the dioxin exposure prevented his physiology from reacting normally to modern medicine and nutrition. Interestingly, the doctors and researchers in my family have agreed to this. War and the aftermath is hell.

The Fountain of Youth, Metadichol?

INSERT CLOTHOClotho is one of the three Greek fates that are responsible for the thread of life in Greek mythology. Clotho is known as the spinner of the thread while the others draw out and cut. In our understanding of physiology, we have named the gene responsible for reduced chronic disease—Klotho. The up regulation of klotho appears to significantly reduce chronic disease. A few to consider are cancer, diabetes, rheumatoid arthritis, and coronary artery disease. Have we stumbled unto the gene that is responsible for the fountain of youth?

The klotho gene appears to be regulated by constituents of the vitamin D family, especially the vitamin D nuclear receptor (VDR). In the past, DR. P. R. Raghavan has shown that Metadichol acts to regulate VDR. In the paper, “Metadichol a Novel Agonist of the Anti-aging Klotho Gene in Cancer Cell Lines,” it is shown how Metadichol up regulates klotho in pancreatic cancer cells by as much as ten-fold against controls. Here is the link to the paper: METADIHCOL-KLOTHO

Here is the paper abstract:


Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of life. Klotho is a transmembrane protein known to be a co-receptor for Fibroblast Growth Factor-23. Klotho gene is expressed in a variety of tissues changes in the levels are associated with many diseases. Klotho is a tumor suppressor in breast cancer and its expression is reduced in human pancreatic adenocarcinoma, and treatment with klotho inhibits the growth of pancreatic cancer cells in vitro and in vivo.

Growing evidence suggests that an increase in Klotho (KL) expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. It remains a challenge today to induce Klotho expression. Herein we show that treating pancreatic cancer cells PANC1, MIAPACA and COLO-205 with Metadichol® a novel food-based lipid emulsion of long chain alcohols at picogram/ml, concentration led to a 4 to10 fold increase in Klotho expression as seen quantitative RT-PCR. These results suggest the use of Metadichol® given its constituents that are present in foods we consume every day is a novel therapeutic intervention for pancreatic cancer and other diseases.

The importance of vitamin D and common food compounds like the long chain alcohol lipids that comprise Metadichol is once again shown. We did not have to spend years in Florida looking for the fountain of youth. I bet Ponce de Leon would be very jealous. –Pandemic Survivor.

Metadichol and Glucose Transport

Once again Dr. P. R. Raghavan has demonstrated how Metadichol works to improve health. In a recent paper, published in the Journal of Stem Cell Research & Therapy, Metadichol is shown to affect the glucose transporter 4 (Glut4 – found primarily on muscle cells) and associated receptor substrates. This explains the control of glucose in patients treated with Metadichol in many case studies.  “Umbilical Cord Treatment with Metadichol, IRS and Glut4 Expressions and Implications for Diabetes” Link to Paper as PDF: IRS-GLUT4-PAPER

It is important to understand that this is a new paradigm for treatment of disease. Typically, in medical treatment research, it has been “one drug–one target.” In the above paper, it is shown how a new understanding of treatment is obtain with “one drug–multiple targets.”  When gene expression as well as nuclear receptors are brought into proper communication, amazing things happen.

Glucose transporters have been shown to increase the transfer of sugars through cell membranes in several ways. Of course, insulation regulation has always been the obvious control of sugar uptake by cells. It is also well known that exercise significantly increases the action of Glut4 which is the transporter for muscle cells. In addition, thyroid hormones play an important role in glucose transporters (which means that iodine and selenium are important). Now for the first time, the regulation of glucose transporters is shown to be affected by a food substance.

Metadichol is a nano-emulsion of waxy aliphatic alcohols, policosanols. The difference of Metadichol and other policosanol supplements is the small particle formulation. Policosanols can be found in many plants. Modern processing of foods has significantly changed the way our bodies take up policosanols. The most concentrated areas of policosanol are on the surface of leaves and husk of seeds and grains.

This is exciting news for diabetics who may be able to control their blood sugar with a substance that does not have side effects, Metadichol. 



Glucose Transporters–Wikipedia

Signaling Mechanisms that Regulate Glucose Transport


Glucose Transport Pathway

Metadichol Paper for Skin Repair

In February, I posted about the effectiveness of Metadichol for skin repair.  You can find that article here. It is amazing how it healed my skin without forming a scab. The healing occurred very quickly. Dr. P R Raghavan has published a new paper about skin. “Metadichol® and Healthy Skin: One Approach Many Possible Cures.”  It is published in the Journal of Clinical & Experimental Dermatology Research: Raghavan, J Clin Exp Dermatol Res 2018, 9:1.  Here is a link to the paper-PDF:Metadichol-Skin-applications

From the Abstract
Metadichol is the first molecule to successfully navigate around the problems involved with promiscuous ligands and targets. It fulfills the goals of the emerging field of Polypharmacology i.e a single drug is able to bind to multiple targets beyond the “one drug, one target” concept. We show how Metadichol is an innovative treatment for treating multiple skin diseases like eczema, acne, diabetic wounds viral and bacterial infection and improving skin texture. Metadichol ® is a safe nontoxic low-cost solution and is an alternative to numerous clinical candidates in combating over 3,000 skin diseases.

Don’t let the science of the paper prevent you from accessing the paper. It shows many pictures of skin disease from baseline to healing.  These are amazing pictures and well worth the time to review. In the paper, Dr. Raghavan describes the many drugs that are currently being used to heal skin. These drugs are designed for one drug, one target. Dr. Raghavan shows how Metadichol binds to multiple targets using links-and-connections diagrams. This action of binding to many targets explains how Metadichol acts to provide quick healing. With about 3,000 skin diseases, it is astounding how one compound can heal multiple diseases

Here are a couple of pictures of my own healing from the February post, article here.  I just don’t have the words to express my delight in how Metadichol works. Here are the many articles that I have posted on Metadichol.

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