Improved Longevity with Metadichol

Life Ext

Scientist at ETH Zurich and the Jena Hospital in Germany completed a study of over 40,000 genes and identified 30 that allowed for extended life span in worms, fish, and mice. Many of the genes extended life span by around 5%, but there was one gene that extended life by up to 25%: BCAT1.  Here’s the story.  It has long been a quest for humankind to extend life.  Here is a story of the Ponce de Leon’s of our era. There are several compounds that have been identified that impact the BACT1 gene.  A study is ongoing for the popular diabetes drug, Metformin, to extend life. To clarify, the BACT1 gene is responsible for catabolism of branched chain amino acids (BCAA).

When Metadichol (a nano version of policosanol) was compared to gabapentin and policosanol it was found to be 3000 times more effective than gabapentin in its impact on the BCAT1 gene.  Here is a link (pdf) to the paper “Improving Longevity with Metadichol by Inhibiting the BCAT1 Gene” for download Metadichol-BCAT1-paper .

It seems that the truth of extending life lies in the idea of having the least number of illnesses during your life.  I wrote an article about this some six years prior:  Filling Good, Looking Better.  In my reading, I think I came across this idea from Linus Pauling during the 70s in his book, “How to Live Longer and Feel Better.” Ideally, it is not just about extending life, the best solution is to have a healthy, vibrant life. Pauling promoted many ideas about how to be healthy (and by-the-way won two Nobel Prizes).  His largest push that he is remembered for is vitamin C.  His promotion of vitamin C has now been supported by modern research. However, he also promoted healthy eating and the reduction of sugar consumption, now a very modern idea.  He even did a study on prisoners to show that it was sugar and not fat that drove up cholesterol.  Long life by reducing disease appears to be the case for BCAAs as they impact your health on many levels.

The idea of extending life by reducing disease gets exciting when considering Metadichol. It appears to reduce disease on many different levels that just happen to include the metabolism of BCAA. Here are the many articles that I have written about Metadichol.  The beauty of Metadichol is that it is a food substance and not a drug and has no known side effects.

The idea is not to just extend your life span, it is to have a happy, healthy, and vibrant life.  To accomplish this: It is about understanding your emotions and living in flow; it is about eating a healthy diet that eliminates flour, sugar, and other processed foods; it is about getting adequate amounts of vitamins and minerals that are much higher than the RDAs of our government; it is about eliminating environmental toxins like nicotine, mercury, and the salt substitute MSG; and it is about eliminating the side effects from prescription drugs (In other words, stay healthy and don’t take prescription drugs).  To your healthy life that will allow you to live to 120 years old. –Pandemic Survivor 


Defend Against Viral Diseases—Including Zika

zikaMuch of the tropical world is being attacked by insect- and otherwise-transmitted diseases.  This includes diseases like Ebola, chikungunya, dengue fever, West Nile, and leishmaniasis (A disease from a parasite carried by sandflies that is showing up more in America.).  Significant fear is now in the American medical community for the surge of cases reported without significant available treatment and prevention. Per the CDC, Zika is now considered a level 2 threat (practice enhanced protection and some are calling it a full blown infection with transmission by mosquitos and sexual activity) in Puerto Rico. The US Congress is so concerned that it recently approved a $1.1 billion Zika funding bill.  With the struggle to find immediate effective prevention and treatment, the nutraceutical Metadichol® may provide a solution.

Metadichol®, a nanoemulsion of policosanol has been found to be effective in vitro of eliminating the infections from cells.  It has also been found effective in two case studies of patients with dengue fever.  Policosanol is long chain lipid alcohols found in many foods like rice, sugar cane, wheat, and peanuts.  The reason that Metadichol® is so effective is because it is better absorbed as the nanoemulsion.

With the favorable findings for other tropical diseases, Metadichol® was tested against the Zika virus with very positive results. Link here for published paper in Journal for Immunological Techniques in Infectious Disease:  In vitro Inhibition of Zika Virus by Metadichol®, A Novel Nano Emulsion Lipid   From the abstract: “Conclusion: Metadichol® is a safe and effective inhibitor for enveloped viruses in humans. Since it is known to bind to the vitamin D receptor (VDR), its action mechanism likely involves the competitive displacement of virus particles from VDR’s on host cell membranes. Metabolism studies of long chain alcohol in fibroblasts suggest that very long chain fatty alcohols, fatty aldehydes, and fatty acids are reversibly interconverted in a fatty alcohol cycle [3]. Metadichol consists of natural components of common foods (classified as GRAS), Metadichol has no known negative side effects. The inhibition of Zika virus by Metadichol® is not surprising, given that we have recently published the results of Metadichol® which showed broad-spectrum antiviral activity against Dengue, Ebola, H1N1, SARS, Chikungunya and other enveloped viruses. (4)

Discoverer of Metadichol®, Dr. P. R. Raghavan, believes that Metadichol® could be used as a preventive for the many diseases.  He states in his conclusion at the end of the paper: Metadichol® could serve as a preventive agent for Zika given that it strengthens the innate immunity through VDR binding, and represent the first key step in preventing diseases. Metadichol® is ready for large scale testing in areas which are ravaged by viruses. Once proven on large populations, Metadichol® could be used as a preventive nutritional supplement in countries where viral fevers are widely prevalent. Metadichol is being sold as a nutritional supplement in a few Asian countries for the last two years and is extremely well tolerated. So far, there have been no reports of any adverse side effects.”

In discussions with Dr. Raghavan, Metadichol, through binding to nuclear receptors, allows the physiology of the human body to act at its highest level.  This is especially true of the immune system.  I believe that we are headed to a new and ancient understanding of how food is critical to health.  It is interesting in how the lipid alcohols act along vitamin D pathways.  It is well established how infections tend to block the action of the VDR.  With Metadichol allowing the body to operate at its optimum, it is even more critical that we have the nutrients necessary to raise our immune system.  The short list is Vitamin D, Vitamin A, vitamin C, Vitamin E, zinc, and magnesium.

It is now time to stop the insane madness of trying to create only synthetic drugs with the many destructive side effects to treat disease. The medical community should look to nutrition first through food and supplementation for the treatment of chronic and infectious disease.

©2016 Mark Pegram

Diabetes Solution – Metadichol

Sym DiabeticA novel approach to solving the issues of diabetes shows Metadichol to be a winner.  Dr. PR Raghavan had originally published a paper for a case study for type 1 diabetes, Case Report of Type 1 Diabetes. Journal of the Science of Healing Outcomes: 2010; Vol 2(8/9):24. After five years and ending treatment the patient is still producing insulin.

  He is now to publish in the Science of Healing Outcomes in July a case report for type 2 diabetes.  Metadichol and Type 2 Diabetes Case Report (Metadichol Type2 Diabetes). From the introduction: “Globally, it is estimated that 366 million people had diabetes in 2011 (5). The number of people with type 2 diabetes is rapidly increasing in every country and in some low to middle income countries, up to 80% of people have diabetes.”  This disease ravishes the body and ultimately causes death from organ failure.  It is a disease of poor eating habits: “Type 2 diabetes is a metabolic disease that can be prevented through lifestyle modification, diet control, and control of overweight and obesity. Education of the populace is still the key to control this emerging epidemic.”

Figure 8The results from the case study are amazing as the person was on no other meds, having chosen to use only Metadichol.  The figure 8 graph from the study shows a clear reduction in glucose as tested during various times throughout the day. The patient’s HbA1C was reduced from 9.8 at baseline to 6.2 at day 84.

Is Metadichol going to work for diabetics?  This is yet to be determined. This study of one person may have had significant changes in glucose because the person changed their eating and exercise habits.  Eating habits are not reported and do have a significant impact on type 2 diabetes.  However, the case study that was first reported for type 1 warrants a significant clinical trial to determine the efficacy for Metadichol for treating diabetes. Since policosanol (the primary component of Metadichol) is a food substance, this trial could be safely carried out on large populations with people that are willing to log their eating habits during the trial.

As reported in other articles on Metadichol, Dr. Raghavan believes that the effectiveness is from how nano-policosanol acts on the vitamin D receptor (VDR).  It appears to act as both an agonist and an inverse agonist which is very unusual.  In addition, Metadichol acts on many genes and other nuclear receptors as reported by Dr. Raghavan.  Will the medical community embrace a food substance for treating disease—all, yet to be determined?  – Pandemic Survivor

Inhibition of Deadly Viruses by a Food Substance

New research shows that an effective antiviral can be made from a food substance.  Policosanol made into a nanoemulsion has the possibility of becoming a significant tool to inhibit the spread of some very serious viruses that include: Ebola, Dengue Fever, H1N1, and SARS.  Published in the April 2016 edition of the Journal of the Science of Healing Outcomes is the paper, “Inhibition of Dengue and Other Enveloped Viruses by Metadichol­®, a Novel Nano Emulsion Lipid,” by P. R. Raghavan, PhD. (dengue-paper – AUTHORS PRE PRINT COPY)

In this paper the author shows case studies of dengue fever recovery of a female 34 and a male 35 in just a few days without any drugs. Also shown in the paper are positive results of in vitro testing for dengue fever as well as many other viruses.  It is the hope that Metadichol® acts toward the other viruses as it has toward dengue fever.  Imagine the less fear that would have been developed during the recent outbreak of Ebola. About 40% of the world’s population is exposed to dengue viral infections with 50 to 100 million infections each year and 22,000 deaths.

Even more important to the average person is the hope that Nano-policosanol is an effective antiviral toward the flu.  Imagine the impact if we could recover very swiftly from the flu with an antiviral that is very effective without side effects.  The very important highlight of policosanol is that it is nontoxic to the human body.  We consume policosanol every day in our foods.  The Nano-emulsion version is easier to absorb and become effective in our immune response. Unfortunately, the part of the plants where policosanol is concentrated is usually thrown away as waste.  Have we lost the avenue toward better immune systems by not chewing the husks from food?

There are over 1,400 pathogens identified to cause disease in humans. There are many more mutating to adjust to an-every changing environment.  How many times in the past year have you heard someone say our use of antibiotics is creating new dangerous bacteria or the vaccine is only 40% effective against this year’s flu?  This is to say nothing to the damage that antibiotics and vaccines may be doing to our microbiota which represents over 100 trillion cells in the human body or ten times human cells.  The use of food with its vitamins, minerals, enzymes, and genetic expressing processes is a natural way of boasting the immune system that has evolved over the ages with our environment.  This may be the answer in our ever persistent battle against pathogens.  We cannot create enough vaccines or anti-pathogen formulas to handle the constant surge of pathogens.

In conversations with the author, Dr. P. R. Raghavan, it was interesting to learn that the finding for the use of Metadichol® against viruses arose out of the use as a supplement. “Chinese and Indians have used herbs and foods to treat illnesses for hundreds of years. My experience in years of developing toxic drugs that do not work, forced me to look for a better alternative. Knowing the importance of vitamin D on human health has ultimately led me to the invention of Policosanol Nanoparticles.” Metadichol® can act along vitamin D pathways and help to restore proper immune health. He continues, “this is not surprising given that policosanol can be considered an open chain form of vitamin D. Policosanol’s main ingredient is Octacosanol which has 28 carbon atoms and vitamin D3 also has 27 Carbon atoms and both are long chain alcohols.”

Potato Skin

Dried Potato Skins

Metadichol has been shown to be effective for many biomarkers (US patents 8,722,093 and 9,006,292) in the nanoemulsion form, and for viruses, bacteria, fungi, and parasites as well. Dr. Raghavan states that he has some very interesting in vitro results for all of these pathogens. He also states that it is very effective in wound healing. “This is not surprising given the fact that dried potato skin was used for skin healing in India. It turns out that potato skin is a good source of the ingredients of Metadichol. In addition, Metadichol also works against Malaria, a parasite, and bacteria like MRSA (see US patent 9,006,292). Recently completed work also has shown that Metadichol inhibits in vitro T-Brucei, a parasite that causes sleeping sickness, T-Cruzi that causes Chagas disease, and Leishmania, a parasite carried by sand flies that leads to Leishmaniosis with symptoms of ulcers of the skin, mouth, nose, etc. All these parasites affect many developed countries in the tropics.  Metadichol® is the only one known in vitro to be active against bacteria, parasites and viruses. This allows researchers for the first time a simple solution that is ready to be tested and deployed world wide to prevent these viruses, bacteria and parasites that affect a large swath of humanity.”

You will have to forgive me, but this reminds me of the explorer movies of the jungle and suddenly there is an illness or injury. The medicine man chews up some leaves and spits it into a poultice.  The person with the illness is healed in just a day or so.  Great stuff for the movies, but there must have been some basis for the fiction. Maybe we have arrived at a time when nutraceuticals are more effective that drugs.

“One good nutraceutical can wipe out the drugs.” Dr. Stephen De Felice

©2016 Mark Pegram

Nano Policosanol Study Shows Increased Vitamin D

Recently a clinical trial was started with 32 patients with many medical issues. P. R. Raghavan, Ph.D. has provided me with some of the initial results of the trail after thirty days.  There are sixty markers for health being used in the study.  The patients are being given 5 mg of per day of Metadichol (nano policosanol) and the markers being tested periodically.

The very interesting thing is that the vitamin D levels (25(OH)D) of the patients have improved by 38.2%.  The baseline for the trial was an average of 12.75 ng/ml.  After thirty days, the average of the group increased to 17.77 ng/ml.  The following graph shows the results of 31 patients with one of the patients left out as there was no change in vitamin D. This gives the result of an increase for 31 patients at 39.4%.  There was no supplementation of vitamin D or increased exposure to sunshine to account for this increase.


In Dr. Raghavan’s findings for Metadichol, he has shown through nuclear receptor studies that Metadichol can act as an agonist, antagonist, and as an inverse agonist for the vitamin D receptor.  In conversations with Dr. Raghavan, he believes that Metadichol acts in place of vitamin D or as a helper to make the action of vitamin D more effective.  He states that the vitamin D receptor is like the conductor of an orchestra to allow other nuclear receptors to properly react for health. I asked him how the nano policosanol knows how to control the receptors.  He states that he believes it is through the communication of the genes in food with the human genome. 

The details of the complexity of nano policosanol interaction with the human genome is yet to be completely determined.  However, many thousands have taken Metadichol as a supplement in Asia for over a year with only positive results of health being reported.  Policosanol is the waxy aliphatic alcohol that is found on the sun exposed portion of many plants.  The Cubans have found in studies that policosanol is very effective in reducing total cholesterol and triglycerides and increasing HDL, the more desirable form of cholesterol for health.  In addition, Dr. Raghavan has shown that Metadichol affects many of the markers for health which include blood sugar and insulin response.  We will know more when the trial is completed.  The Chinese have allowed the product to be marketed as boosting the immune system. It is particularly effective for wound healing and Dr. Raghavan also plans to show how Metadichol affects metabolic age. 

Metadichol in Southeast Asia

A video of people using Metadichol as brand name Polilex has been posted to you tube by Polilex. This is a very remarkable video. Typically what you see in videos is young people talking about how wonderful things are. In this video, it is mostly old people that are suffering from an array of chronic diseases.

It is amazing to think that something as simple as an emulsion of the waxy substance found on most plants leaves can have such effects. As we move forward in our understanding of nutrients from food, I believe there will be amazing results. How modern foods are processed is of extreme importance to our health.

The video is high quality but the English subtitles are sometimes hard to read.

Update on My Experience with Metadichol

Metadichol is a supplement that is policosanol in a nano form. This nanoemulsion allows for better absorption of the policosanol so that it can act properly. When properly absorbed, it appears to work significantly in the body for health.

Earlier I described how when I first got the samples from Dr. P R Raghavan the discoverer, my wife had just come down with shingles. It was amazing as the pain went away after only twenty four hours.

I had reported earlier how much my fourteen year old dog has improved. Sophie is now jumping up on the coach again. An act she had not been able to do before the use of Metadichol. She also continues to get much more playful. I never thought we would ever see her act like a puppy again.

I decided to give one of the samples to my brother. Here was a case of abuse by the medical profession of improperly giving my brother testosterone. After several years of use, he started showing many side effects from use of this steroid. The worst physical appearance was loss of blood flow to his legs. They looked like the legs of a long term diabetic. He had developed dark blue spider veins in his legs and significant swelling. After a month of using Metadichol, his legs and toes went from blue to pink. The blood had started to flow properly again and the swelling is gone. He reports a significant improvement in health since he started to use Metadichol. It will be interesting to see how much improvement he will have. It is amazing as the testosterone commercials drone-on on TV.

My sister is about eighty. She has had much compliant of knee pain. It was keeping her from sleeping. I gave her a sample of the gel. She reported that the pain was reduced enough the first night to allow her to sleep. She also reported that the pain was completely gone in about three days. She is also a type II diabetic and now wants to try with the liquid to see if there is a reduction in her fasting blood sugar.

I have a friend that I gave a sample of the gel after he had surgery on his chin. He has reported that the scar on his chin has almost completely gone after a month of usage. This has amazed even the doctor.

My sister-in-law was given a sample of the gel. She reported that a rash on her arm went away in just a few weeks. She has suffered this rash for years.

I gave a friend a sample after she complained of constant nose congestion. She was told by her  doctor that she was a carrier for MRSA in her nose.  She has reported now that her nose has been clear for the first time in years.

I cannot tell any more improvement in my own health. However, I did take my blood pressure last night and it was 115/70. I don’t ever recall my blood pressure being at this level. It usually runs toward pre-hypertension. It is amazing that Metadichol works along so many different pathways. – Pandemic Survivor