Metadichol as Mediator of Inflammatory Response

Note to readers: This article is to notify researchers to the possibilities of Metadichol as a mediator of the AHR-Nrf2 pathway for inflammatory response. Metadichol’s action on nuclear receptors is hugely significant. The importance of Metadichol’s effect is in regulating inflammatory response to outside agents. Outside agents may include drugs, manmade toxins, or even response to light (think sunburn and/or retinal protection). In this paper, it is shown how Metadichol may be significant in treating chemo resistant cancer.

Metadichol ®. A Novel Inverse Agonist of Aryl Hydrocarbon Receptor (AHR) and NRF2 Inhibitor
Journal of Cancer Science and Therapy 

Raghavan, P R
Nanorx Inc., Chappaqua, New York, USA,  

Abstract
Metadichol ® a novel nano-emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2)) and is a transcription factor that is ubiquitously expressed at low levels in all human organs and regulates a primary cellular defense mechanism, tight regulation to maintain cellular homeostasis. AHR is highly expressed in a broad panel of tumors, AHR is induced by 2,3,7,8-tetrachloride-benzo-p-dioxin (TCDD) Metadichol® as a inverse agonist against AHR could be potentially useful in the treatment of such diseases. Strong in vivo evidence suggests that TCDD can stimulate cross-talk between AHR and Nrf2. The constitutive up regulation of Nrf2 signaling appears to drive the cellular proliferation and resistance to chemotherapy in various cancers. Therefore, pharmacological inhibition of Nrf2 by Metadichol ® holds promise as a therapeutic strategy in chemo resistant forms of cancer. 

Here is a link to the PDF: metadichol-AHR-Paper

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Metadichol® Induces High Levels of Vitamin C

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Post LabelLinus Pauling, a two-time Nobel Prize winner, spent a significant effort in promoting vitamin C in the prevention and treatment of disease.  He was scoffed at by the mainstream medical community. Now, there appears to be better acceptance of using vitamin C to treat disease. It is interesting to note that humans, unlike other mammals, do not make vitamin C. Goats are known to make large amounts of vitamin C each day.  A one hundred fifty-pound goat can make as much as 13,000 mg each day. I typically take one to two grams of vitamin C per day.  If my noise is running, I have found that it will stop in a few hours by taking a gram of vitamin C per hour.   

Typical reference range for plasma vitamin C is 0.2 – 2 mg/dL or 11 – 114 µmol/L.  In the study, Dr. Raghavan found that oral supplementation of 5 mg of Metadichol per day raised the plasma vitamin C to or above high normal.  Speculation has been that Metadichol accomplishes this by reducing the requirement for vitamin C as the body gets healthier, recycles vitamin C, or turns on the gene responsible for producing vitamin C.  In any case, this case study shows the effectiveness of Metadichol in reducing disease.
Metadichol® Induced High Levels of Vitamin C: Case Studies
Raghavan PR* Metadichol-Induced-high VitaminC levels (link to paper)
Abstract
We recently reported that Metadichol® [1] brings about a three to four-fold increase in Vitamin C levels in patients without the use of Vitamin C supplementation. In this study of 6 patients who experienced a 5-12 fold increase in plasma Vitamin C levels higher than 80-100 u mol/L level which is the highest reported to date by oral supplementation at high doses of Vitamin C. Metadichol improved in these patients TSH levels, normalized High Blood pressure, fasting glucose levels, reduced eosinophil count, high triglycerides, body fat reduction and increased bone mass, normalized sodium levels, reducing high insulin levels, increased creatinine output in urine and also reducing of Red Cell Distribution width %. Metadichol thus serves as a surrogate for Vitamin C at doses of 5 mg per day as opposed to mega doses that are currently used.

Other articles on Metadichol

Metadichol® Now Available in North America

Metadichol is now available in North America as an immune system spray and as a skin spray.  It is labeled as (link to site) Nano-Ojas.  Ojas is a word used in Ayurvedic medicine, the vital force that governs hormonal balance. The company has provided Nano-Ojas through an online site that was formed by Tinny S. Srinivasan and Nithasha S. Koukoumanos.  Mr. Srinivasan has forty years of experience in the aerospace industry and Ms. Koukoumanos has worked primarily with children with emotional and behavioral disorders. 

Metadichol is a nano-emulsion of policosanol.  Policosanol is the waxy substances (long chain aliphatic alcohols) that are found in the highest concentrations on the sun-splashed portion of plants. As modern humans, we no longer chew the husk from grains and nuts, the rich source of policosanol.  The extreme tooth pressure required to break open the husk is not the normal experience of modern foods. This has removed a very valuable nutrient from our diet. Mothers knew the importance of chewing foods when they constantly admonished you to chew your food.  Now with modern processing, the food has been chewed for us, but unfortunately, most of the policosanol parts have been removed. Dr. P.R. Raghavan has solved this issue by providing policosanol as a small particle emulsion.

The policosanol in our diet over the ages has acted to boast our immune systems and enhances the action of other vital nutrients.  It has been found to act on over 700 genes that are responsible for disease. There are also many other genes that are responsible for general wellness as well as nuclear receptors that are orchestrated by policosanol. All of this has been confirmed through gene studies by Dr. Raghavan.

To your good health! –Pandemic Survivor 

ImmuneSpray2

 

July Papers for Metadichol

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Dr. P. R. Raghavan has written two new papers for Metadichol. This again shows the diversity with which Metadichol acts.  Metadichol acts on hundreds of genes to allow the body to repair.

The first paper is about the only known substance to act for red blood cell distribution width improvement (RDW). It is believed that RDW is a marker for many types of autoimmune diseases.  Here is the summary for the paper.

 Abstract

Red blood cells originate in the bone marrow. Red cell distribution width (RDW) show sizes of circulating erythrocytes (RBC) and has been explored in several large clinical databases to be a robust marker of adverse clinical outcomes in patients. The prognostic value of RDW is seen in other conditions with end-organ dysfunction such as renal failure or. Elevated RDW levels are of significance in diseases such as kidney diseases. The high RDW levels are an indication of increased oxidative stress and closely related to the presence and poor prognosis of the disease. No known therapy exists that can normalize RDW levels. In this paper, we present here case studies using Metadichol®, that leads to normal RDW levels in patients with CKD and PKD.  Here is the link: RDW-paper

The second paper is about allowing vitamin C to be naturally produced in the body.  This is very unusual, but Dr. Raghavan believes that Metadichol activates the gene responsible for producing vitamin D.  This is based on the genes that are activated that were found in his gene studies.  Here is the summary for the paper.

Abstract

Vitamin C, also known as ascorbic acid, is a water-soluble antioxidant. Today we meet our requirements of vitamin C through consumption of fruits and vegetables or by supplementation. Homo sapiens cannot produce vitamin C like many other species that can convert glucose to vitamin C. The gene for enzyme production is dormant in humans. The gene, GULO, that we all carry converts glucose to Vitamin C. in other species but not in humans and primates. The open-label study showed Metadichol® raised levels of vitamin C by 3-fold, endogenously without supplementation of Vitamin C. Possible mechanisms for the increased Vitamin C levels through antioxidant pathways are presented. Metadichol® [1] is a nano-formulation of long chain alcohols derived from sugar cane. In addition to increased Vitamin C levels reduction in Potassium and uric acid, and decreased blood pressure and improvement in quality of life issues were also observed.  Here is the link to the paper: vitamiC-metadichol

Whatever you may think about the action of Metadichol, I believe it to be truly amazing. Here is a link for all Metadichol articles and papers.  –Pandemic Survivor

Hypertension – Reduced with A Food – Metadichol

Our diets over the last fifty years have been shifted away from fat and toward carbohydrates with the belief that higher amounts of fat were causing cardiovascular disease (CVD). As this move toward higher density carbs occurred, blood pressure also increased along with the issues of higher incidence of CVD and stroke. In the following study, a food substance, that is typically tossed in the processing of sugar cane, was found to reduce blood pressure and c-reactive protein (CRP) and increased circulating vitamin C. The paper describes the action of nano-policosanol as acting along vitamin D pathways.

Here is my blood pressure as I write this at 4 AM–not bad.Hypertension w

Dr. P.R. Raghavan has given us Metadichol, a nano-policosanol, to reduce blood pressure.  Policosanol, as long chain fatty acids, is found in high concentration on sugar cane and the husk of seeds.  Here is the paper that was just published for a sixty-week open label study. The remarkable things are that blood pressure is reduced in only three weeks, the production of vitamin C in humans, and reduced CRP, an indication of reduced inflammation.

Systolic and Diastolic BP Control in Metabolic Syndrome Patients with Metadichol® a Novel Nano Emulsion Lipid – Journal of Cardiology and Cardiovascular Therapy Case Report Volume 5 Issue 2 – May 2017 DOI: 10.19080/JOCCT.2017.05.555660 Metadichol-Hypertension

To combat high-blood pressure the normal course is to:

  • Eat a healthy diet
  • Regular exercise
  • No nicotine use as it shrinks arteries
  • Limit alcohol
  • Maintain a healthy weight

The above is the typical verbiage that you get from your doctor. I wonder just how many times the physicians say that on any given day. It is apparent that a healthy lifestyle is everything. Of course, government and its agencies have failed us in defining a healthy diet. The common American diet was defined to promote the economy. If you don’t believe this then ask yourself this question: Why do we spend almost twice as much on healthcare as we do on food?

Poor eating habits are the cause of many chronic diseases.  Hypertension falls in this category. The first time my realization that diet was critical to controlling blood pressure occurred when I was reading “Protein Power” by Drs. Michael and Mary Eades.  They warned of blood pressure dropping significantly with the reduction of carbohydrates. This raises the question of our health actions over the last fifty years. Reduce the amount of fat and increase sugar?  Sugar has typically not been considered as dangerous, however, I believe it’s the worst policy we could have made. Linus Pauling (interesting that this is the vitamin C guy and Metadichol helps the body produce vitamin C) showed in the 1970s that sugar was more responsible for increased cholesterol than fat through his studies with prisoners.

  • The real solution to maintain a normal blood pressure is to eliminate sugar and flour from your diet. Grains were not meant to be finely divided for consumption by our physiology.  Sugar is not meant to be consumed outside of its normal occurrence in vegetables and fruits. This is what is meant when we are told to consume a healthy diet.

Metadichol will help maintain a lower blood pressure. Metadichol acts in many ways in controlling our biological actions. The beauty of Metadichol is that this food substance has no known side effects. We no longer consume policosanol that is found in the husk of seeds. It appears that our body needs these long chain fatty alcohols. Metadichol is taking the husk into a modern factory and chewing them for us. Remember the words of your mother: Chew your food!  Of course, if you don’t have the right part of the food to be chewed, factory chewing by others is okay.

The irony is that nature gave us policosanol on the plants that are high in sugar, and we throw way nature’s protection from sugar.  We then concentrate the sugar through modern processes and consume it in great amounts.  Results are devastating to our health. We now develop a substance that counteracts the effects of sugar, that nature originally meant us to consumed with the plant.  Sugar drives up serum cholesterol more so than fat. The result of a high sugar diet without the protection of policosanol is CVD and stroke. More irony, the original intent of the Dr. Raghavan was to improve the way policosanol reduced cholesterol as shown by the Cubans. Nature is laughing at us.

One of the very interesting findings in this study was the increase in vitamin C. The paper indicates that humans made vitamin C as part of our physiology.  At some point, one of the three enzymes that makes vitamin C from sugar was no longer produced.  Metadichol appears to turn on the gene responsible for producing this enzyme and higher vitamin C levels happen. This means reduced inflammation, as indicated by a reduction in CRP, and the possibility of a longer lifespan with less disease.

This is really-exciting stuff. The possibility of increased life span with reduced inflammation and disease through a food substance that can easily be supplemented with no side effects–Metadichol.

We took the chewing of grains into the milling operations to help foods be easier to consume. Sugar was concentrated through industrial processes as our body craves this substance. It should also be noted that sugar was concentrated to help in the production of alcohol–another craved substance. Both things, milled grains and concentrated sugar, made food easier to consume and have significant impact on our economy, but they are not healthy. By not being healthy, we again have made a significant impact on our economy with increased healthcare and insurance. And, the government said, “It is good.”  –Pandemic Survivor

Rheumatoid Arthritis and Osteoporosis–Vitamin D Pathways

Arthritis is an autoimmune disease that causes inflammation of the joints.   There are many types of arthritis, but they all seem to come from vitamin D deficiency.  Vitamin D deficiency results in many types of autoimmune diseases. At Vitamin D Deficiency Survivor, we have always encouraged you to be sure that your vitamin D levels are in the high normal range when trying to relieve these very serious diseases.  In this article, we present a case study of a patient with rheumatoid arthritis and osteoporosis that was treated with Metadichol.

Here is the article heading and abstract from the paper recently published by the Journal of Arthritis.

 Screen Shot 2017-05-05 at 06.13.42

Here is the link: Rheumatoid Arthritis and Osteoporosis: A Case Study, P. R. Raghavan, Journal of Arthritis

It is very interesting to note in this article that the patient improved in many markers for health.  C-reactive protein (CRP) is a very important marker and signals an inflammation effect for many pathways of health.   In this study, the patient had a CRP of 1.1 that rose three years later, at baseline before treatment, to 83.  After sixteen weeks of treatment, the patient returned to his normal level—see figure 4.6.  This means that inflammation from all sources was reduced.

The treatment used in this study was Metadichol.  Metadichol is a nanoemulsion of naturally occurring policosanol. The nanoemulsion of policosanol is more easily absorbed and fines its way into the cells where it acts along vitamin D pathways, and the proper expression of many disease related genes (over 700 genes). 

I had arthritis in my pointing finger on my left hand for many years.  With high levels of vitamin D and other vitamins and minerals, it had still not returned to normal.  In three months with treatment of Metadichol, it returned to its normal size and there was no more pain.  Prior, it had been twenty-five percent larger than my right-hand finger.  My sister had significant pain in her knee that she had been told was from arthritis. She described it as very painful.  After treatment with Metadichol for three days, she reported that the pain was reduced by fifty percent.  I know that she was supplementing with a significant amount of vitamin D3. 

The author is very excited about the increase in bone mass density (BMD). This is nothing new to those that understands how vitamin D and minerals work to increase bone mass. Here is a post that I did in 2010 showing that an adequate amount of vitamin D increases bone mass.  The post is about a warning from the FDA for bisphosphonate drugs.  Here is also a link to the paper showing a 23% increase in BMD with vitamin D3 in a nursing home. 

Vitamins and minerals and other nutrients do not work in isolation for health.  It is an adequate amount of all nutrients that is important for health.  We have lost a significant intake of policosanol from processed foods.  Policosanol occurs in the sunny parts of plants, and it occurs at high levels on the husk of seeds and grains.   Think how we have lost access to this vital nutrient by not chewing the husk off foods.  Dr. Raghavan has presented us a solution to this modern problem of processed foods.
–Mark Pegram

Metadichol—Use for Metabolic Disease

Sym DiabeticMetadichol was reported last year as being effective for Type 1 and Type 2 diabetes in case studies.  Two issues for diabetes are insulin resistance and obesity.  A target that is now being researched for metabolic disease is GPR-120.  In research by others, GPR-120 agonist has been found effective in anti-inflammatory, insulin sensitization, and anti-obesity effects.  Metadichol has been found as a GPR-120 agonist.

The paper, Metadichol® A Novel Nano Lipid; GPR-120 Agonist, reaches the conclusion that: “Metadichol has the potential to serve in mitigating diabetes with a broad spectrum of activity and with a safety that with [of]no toxicity at doses of up to 5000 mg/kg [20-22]. Metadichol is a far [more] effective substitute to prescription drugs, which have been largely ineffective in diabetes and have many side effects that add to health care costs.”

Here is a link for you to download the paper: GPR-120 Agonist Metadichol

Mark Pegram

Citation: Raghavan P.R. Metadichol® A Novel Nano Lipid; GPR 120 Agonist. Int J Diabetes Complications. 2017; 1-3.

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.   Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6  https://www.ncbi.nlm.nih.gov/pubmed/24997608