Metadichol and Skin Repair

In last post, we discussed the advantages of Metadichol in stem cell development. I suspected several years ago that somehow Metadichol works differently to aid in the repair of skin tissue. In this article, I will show two examples from my own experience with skin repair.

Case 1–A cut from walking in the woods

I took a walk through some very thick woods in September 2016. I received a cut on each arm from snags in the woods. The long cut was bleeding badly. Remembering that policosanol is on most sun-splashed portions of plants, I chewed up some white oak leaves and placed the chewed leaves on the cut. The bleeding stopped almost immediately. I’m not sure why the chewed leaves stopped the bleeding. It was something that we did as children on the farm. I knew that it would work. 

Sep 20A1cHere is a picture of the cut the next day. As you can see it had started to heal. I had treated it with Metadichol spray when I got home that night.

I continued to treat it once a day, and here is the result after seven days. As you can see in the photo, the cut is very nearly healed. There was no soreness during the treatment period. It is interesting to note that no scab formed on the cut. Sep 27A1c

Since I had a cut on the other arm that was not as significant, I decided to treat it with triple antibiotic ointment. I treated it with the ointment on the night that I came home. Here is a picture on the next day. Sep 20B1c

I continued to treat it once a day with the triple antibiotic ointment. Sep 27B1cThere was significant soreness that continued throughout the seven days. Here is a picture of the result. As you can see, the scab is still in place, and there is some healing. I started treating it with Metadichol, and it healed in several days. 

Case 2–A burn wound that was not healing

August 28A friend of mine contacted me in August 2015 to say that she had a burn on her finger that was not healing.Sep 3 I am not sure how long it had been since she had the burn. She said she had been to a doctor, and he gave her a steroid ointment. I gave her a bottle of the Metadichol and suggested that she spray the wound with one spray twice per day.  She said she no longer used the steroid ointment.

Sep 7Here are pictures of the wound from day one, day six, and day ten. It is amazing how the wound progressed to healing from day six to day ten. She called me to ask if she should break the blister on day six. I told her that I did not think that was a good idea. The day ten photo speaks to the accuracy of this suggestion.

As you can see, my experience with using Metadichol for skin repair is significant. –Pandemic Survivor


Enhanced Development of Stem Cells with Metadichol

3D Stem CellsMy first experience with Metadichol was the quick healing of a wound. A wild cherry tree had fallen in the woods behind my house. I had sawed the tree into fire size logs and stacked them in a pile. As I threw one of the logs onto the pile, it caught the back of my hand and caused a two-inch-long cut. I treated the cut with the Metadichol spray. The healing took place twice as fast as my normal experience with cuts. I suspected then that somehow stem cells must have been increased or differentiated or both by the Metadichol for the quick healing (A future article will show two examples of healing with Metadichol from my personal experience.) Dr. P. R. Raghavan has had research done by Skanda Labs to show that stem cells are increased in umbilical cord blood when treated with Metadichol.

The research paper, Metadichol and CD34 Expression in Umbilical Cord Blood, is published in the Journal of Stem Cell Research & Therapy on January 29, 2018. CD34 is a marker for the action of stem cells in many types of cells within the body. During the study, an increase of CD34 protein was shown with the application of Metadichol. Injection of CD34 enriched hematopoietic stem cells have been clinically used for treating spinal cord injury, cirrhosis and peripheral vascular disease. Link to paper as PDF: Metadichol-CD34

There are many types of stem cells within human biology. The two basic classes are embryonic stem cells and adult stem cells. The ability of Metadichol to enhance the development of and the differentiation into a variety cells is critical to healing. This may mean that Metadichol can be used in many different cases of disease to promote healing. Metadichol is simply a nanoemulsion of policosanol or a food substance. Policosanol is a waxy alcohol that is found of many plants which we use for food. There are no known side effects with the food, policosanol.

Science is now using genetic manipulation to help in the development of stems cells. The result is the possibility of rejection of the developed cells and serious side effects. Destruction of cells in the attempts to heal cancer has required the replacement of healthy cells. This has been done typically by using the person’s cells and genetically manipulating them and replacing them in the body. Earlier and current attempts in replacing cells have been done through transplants from donors as in bone marrow transplants. Also, cord blood is now being frozen by some for future use in healing because of the concentration of stem cells.

This is very exciting news. The development of a natural substance used for healing confirms the fact that “Food is medicine and medicine is food.” Thanks for reading. –Mark Pegram

Other Post (22) on Metadichol:

Resources and Useful Links:

Human Production of Vitamin C

Human C

I had reported early the finding of Dr. P. R. Raghavan for increased levels of vitamin C in diabetes cases when treated with Metadichol. (Metadichol Induces High Levels of Vitamin C) It appears that the increase was activation of the gene responsible for making the enzyme necessary for the completion of vitamin C production.  This was based on the findings of Dr. Raghavan’s gene studies. This is true in animal studies not yet proved in Humans as the GULO gene is non-functional. Does Metadichol activate the dormant GULO gene in humans despite it being mutated? Studies provided by Skanda Life Sciences shows that Metadichol does activate the gene responsible for the missing enzyme in mouse studies. “Metadichol, Vitamin C, and GULO Gene Expression in Mouse Adipocytes” Link to PDF Metadichol-Vitamin-C-Gulo The loss of production for vitamin C in humans and not in other animals is a mystery.

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Vitamin C is so important to immune health that without it we would soon die of scurvy. Sailors in past centuries developed the disease because of the lack of fresh vegetables and fruits. The British used limes to provide vitamin C and the Germans used sauerkraut (Thus, the associated nicknames). Recently a physician in Norfolk Virginia found that he could treat septic shock (deadly blood infection) with vitamin C, thiamine, and hydrocortisone. The physician has had only one death after treatment of 150 patients. This shows the significance of how important vitamin C is to the immune system, and may explain how Metadichol works so effectively on so many different diseases.

Metadichol boosts the immune system in many other ways. One of the more important ones is how it affects the action of the vitamin D receptors. The vitamin D receptor acts like a conductor of the orchestra for other nuclear receptors. One very important action of the receptors is the making of antimicrobial peptides that are killer cells for all pathogens. Vitamin C supports many of the functions of neutrophils. Neutrophils (white blood cells), another important immune system function, ultimately converts to various types of killer cells that hunt down pathogens.

Vitamin C also has a role in stem cell production as well as collagen folding. This makes Metadichol very significant in wound healing. Treating and preventing infection and acting in wound repair. It is truly amazing how this one substance can act in so many ways. Collagen is useless without folding of the molecule. Because of the folding of collagen, vitamin C is also very important for building strong bones. Thanks for reading­­–Mark Pegram

More Resources:
Effects of Vitamin C on Neutrophil Function:
Other articles about Metadichol and research papers:  

Hope for Psoriasis

Nanoscience has brought new hope for psoriasis. There have been many treatments available for psoriasis through the years. Now an over the county supplement has brought a solution. Metadichol is an over the counter supplement that is simply policosanol made into a small particle emulsion. Policosanol is the waxy substance found on the sun-splashed parts of plants. The case studies in this new paper that was just published are amazing in how it resolves the issues around this disease that has no apparent resolution in modern medicine.

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Raghavan PR* Nanorx Inc Chappaqua, New York, United states


Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate.

The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz® that blocks IL17 for treatment of plaque psoriasis.

Metadichol® a nano-formulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.

This paper is published in the Journal of Clinical & Experimental Dermatological Research. Citation: Raghavan PR (2017) Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis. J Clin Exp Dermatol Res 8: 433. doi:10.4172/2155-9554.1000433 This is an open access journal.  Link Prr-Psoriasis-paper

Most diseases are connected through a network that is commonly called network pharmacology. The paper shows how Metadichol affects many different diseases through this network. It is definitely worth your time to look at the paper. Presented are seven case studies with psoriasis resolved. Picture here is whole body psoriasis that is resolved in twenty-four weeks. The participants used the spray orally and applied it directly to the areas of concern.

pic psoriasis

Other than Metadichol, I do believe that the over the counter ointment of vitamins A and D is the best. Metadichol appears to work along pathways for A and D.  Typically, vitamins are currently recommended at levels that are to resolve basic body needs without looking at higher levels for improved health.

Metadichol as Mediator of Inflammatory Response

Note to readers: This article is to notify researchers to the possibilities of Metadichol as a mediator of the AHR-Nrf2 pathway for inflammatory response. Metadichol’s action on nuclear receptors is hugely significant. The importance of Metadichol’s effect is in regulating inflammatory response to outside agents. Outside agents may include drugs, manmade toxins, or even response to light (think sunburn and/or retinal protection). In this paper, it is shown how Metadichol may be significant in treating chemo resistant cancer.

Metadichol ®. A Novel Inverse Agonist of Aryl Hydrocarbon Receptor (AHR) and NRF2 Inhibitor
Journal of Cancer Science and Therapy 

Raghavan, P R
Nanorx Inc., Chappaqua, New York, USA,  

Metadichol ® a novel nano-emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2)) and is a transcription factor that is ubiquitously expressed at low levels in all human organs and regulates a primary cellular defense mechanism, tight regulation to maintain cellular homeostasis. AHR is highly expressed in a broad panel of tumors, AHR is induced by 2,3,7,8-tetrachloride-benzo-p-dioxin (TCDD) Metadichol® as a inverse agonist against AHR could be potentially useful in the treatment of such diseases. Strong in vivo evidence suggests that TCDD can stimulate cross-talk between AHR and Nrf2. The constitutive up regulation of Nrf2 signaling appears to drive the cellular proliferation and resistance to chemotherapy in various cancers. Therefore, pharmacological inhibition of Nrf2 by Metadichol ® holds promise as a therapeutic strategy in chemo resistant forms of cancer. 

Here is a link to the PDF: metadichol-AHR-Paper

Metadichol® Induces High Levels of Vitamin C

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Post LabelLinus Pauling, a two-time Nobel Prize winner, spent a significant effort in promoting vitamin C in the prevention and treatment of disease.  He was scoffed at by the mainstream medical community. Now, there appears to be better acceptance of using vitamin C to treat disease. It is interesting to note that humans, unlike other mammals, do not make vitamin C. Goats are known to make large amounts of vitamin C each day.  A one hundred fifty-pound goat can make as much as 13,000 mg each day. I typically take one to two grams of vitamin C per day.  If my noise is running, I have found that it will stop in a few hours by taking a gram of vitamin C per hour.   

Typical reference range for plasma vitamin C is 0.2 – 2 mg/dL or 11 – 114 µmol/L.  In the study, Dr. Raghavan found that oral supplementation of 5 mg of Metadichol per day raised the plasma vitamin C to or above high normal.  Speculation has been that Metadichol accomplishes this by reducing the requirement for vitamin C as the body gets healthier, recycles vitamin C, or turns on the gene responsible for producing vitamin C.  In any case, this case study shows the effectiveness of Metadichol in reducing disease.
Metadichol® Induced High Levels of Vitamin C: Case Studies
Raghavan PR* Metadichol-Induced-high VitaminC levels (link to paper)
We recently reported that Metadichol® [1] brings about a three to four-fold increase in Vitamin C levels in patients without the use of Vitamin C supplementation. In this study of 6 patients who experienced a 5-12 fold increase in plasma Vitamin C levels higher than 80-100 u mol/L level which is the highest reported to date by oral supplementation at high doses of Vitamin C. Metadichol improved in these patients TSH levels, normalized High Blood pressure, fasting glucose levels, reduced eosinophil count, high triglycerides, body fat reduction and increased bone mass, normalized sodium levels, reducing high insulin levels, increased creatinine output in urine and also reducing of Red Cell Distribution width %. Metadichol thus serves as a surrogate for Vitamin C at doses of 5 mg per day as opposed to mega doses that are currently used.

Other articles on Metadichol

Metadichol® Now Available in North America

Metadichol is now available in North America as an immune system spray and as a skin spray.  It is labeled as (link to site) Nano-Ojas.  Ojas is a word used in Ayurvedic medicine, the vital force that governs hormonal balance. The company has provided Nano-Ojas through an online site that was formed by Tinny S. Srinivasan and Nithasha S. Koukoumanos.  Mr. Srinivasan has forty years of experience in the aerospace industry and Ms. Koukoumanos has worked primarily with children with emotional and behavioral disorders. 

Metadichol is a nano-emulsion of policosanol.  Policosanol is the waxy substances (long chain aliphatic alcohols) that are found in the highest concentrations on the sun-splashed portion of plants. As modern humans, we no longer chew the husk from grains and nuts, the rich source of policosanol.  The extreme tooth pressure required to break open the husk is not the normal experience of modern foods. This has removed a very valuable nutrient from our diet. Mothers knew the importance of chewing foods when they constantly admonished you to chew your food.  Now with modern processing, the food has been chewed for us, but unfortunately, most of the policosanol parts have been removed. Dr. P.R. Raghavan has solved this issue by providing policosanol as a small particle emulsion.

The policosanol in our diet over the ages has acted to boast our immune systems and enhances the action of other vital nutrients.  It has been found to act on over 700 genes that are responsible for disease. There are also many other genes that are responsible for general wellness as well as nuclear receptors that are orchestrated by policosanol. All of this has been confirmed through gene studies by Dr. Raghavan.

To your good health! –Pandemic Survivor