Vitamin D3 Misdirection

misdirection“Misdirection is a form of deception in which the attention of an audience is focused on one thing in order to distract its attention from another.” -Wikipedia

Misdirection is a phrase normally used to describe magic and pick pocketing. Over the decades, since the discover of vitamin D for the use in medicine and health, misdirection of vitamin D has been the order of the day. Certainly, a lot of the misdirection is a poor understanding of all the benefits that vitamin D3 provides in very small quantities.

Also, the lack of understanding of how toxic higher levels of some sterols can be, like vitamin D2. When ergosterol is irradiated with UV light it is almost impossible to not form a toxic substance called toxisterol. Ergosterol was first isolated from ergot fungus. If you recall, ergotism or St. Antony’s Fire is the burning pain in limbs and manic behavior, sometimes with hallucinations. The ergot is found on mushrooms and fungus on grains like rye and corn when harvested after long periods of rain.

I believe the warnings about vitamin D that were identified during the last IOM study for vitamin D and calcium were all related to studies that were performed with vitamin D2. Vitamin D2 is not safe with a serum 25(OH)D2 higher than 50 ng/ml, and the IOM board said as much. However, they did not distinguish between D3 and D2 which is a huge mistake. There does not appear to be any toxicity with vitamin D3 under 200 ng/ml of 25(OH)D3. So, staying under the upper range of 100 ng/ml of 25(OH)D3 for treating chronic disease should be reasonably safe. During the first attempt of using vitamin D, there were no toxicity incidents reported until vitamin D2 started to be substituted for vitamin D3.

In the early 1900s, it was assumed that ergosterol occurred naturally in humans. From Moon and Reich in 1975, The Vitamin D Problem An Important Lesson..  “We know today that this interpretation is not correct. It is specifically 7-dehydro-cholesterol which is activated by ultraviolet radiation to have antirachitic properties, and the plant steroid, ergosterol, does not occur naturally in humans or other animals. By the time this mistake was discovered in the mid-30’s, it was too late to turn the tide and rather than recognize the nonidentity of irradiated ergosterol and the natural antirachitic factor, it was proposed that “vitamin D” is represented by a large number of activated sterols which constitute the ‘vitamin D-group.’” “Prior to the advent of irradiated ergosterol there is a paucity of information regarding possible toxicity of cod liver oil vitamin D.” “Within months after the introduction of Vigantol—one of the first commercial preparations of irradiated ergosterol —reports of toxicity began to appear.” “From that time to now, these reports on the toxicity of the “vitamin D group” have literally flowed from laboratories and clinics throughout the world at a phenomenal rate of more than one per month.”

With this understanding about the difference in vitamin D2 and D3 from the 1930s, why have we continued to use vitamin D2. If intentional to not correct the problem, then it is simply about the money in health. This type of error goes on even today with the use of folic acid as equal to methyl folate. At least half the population cannot covert folic acid, a manmade molecule. Last year, it was suggested by the FDA that the word folate not be allowed on vitamins. Many mothers continue to have babies with neural tube defects. This is to say nothing of the harm done to the general population by using folic acid as a nutritional additive in processed grains. The science is clear, it is the “money lords” that are the problem with health.

This type of error of either using natural compounds that are foreign to humans or synthetic compounds causes side effects. In either case, the side effects can be very serious to health. The fear in following the science is that the population could become extremely healthy. People would live longer. Very few over the county remedies, especially for colds and the flu, would no longer be necessary. The number of doctor visits could be reduced by as much as seventy-five percent as one medical practice discovered when adding necessary vitamins and minerals to their routine treatments. If you were a congressman in the US, what would you decide. A Social Security system that would fail because people live ten years longer, and the medical segment of the economy being reduced by fifty percent (medical industry is now twenty percent of GDP, approximately, which would cause a ten percent reduction in the total economy) or a large ill population to maintain the status quo?  Would there be more deaths and hunger as the economy failed? A true dilemma. I do believe that acting to sustain an institution without regard to the wellbeing of the people it serves is pure evil. If the science had been allowed to come forward as it was discovered, we would not be in this situation of poor health and declining life span. –Pandemic Survivor

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Vitamin D3 Obfuscation

GraphicAs I have not written in many months, I would like to apologize for my absence. I had an injury in the spring that has taken many months to recover. I am now nine weeks since surgery and three weeks into rehab. In any case, I have recovered from my incapacitation enough to write. I would like to say that the American medical institutions have the best diagnostic capability in the world.

The attack on vitamins and minerals continues. The mere suggestion that a vitamin or mineral might help with a chronic disease will bring outrage from the “medical community.” Typically, it is not from your doctor, although he may have fallen into the allure of medical propaganda. Also, your doc must follow medical guidelines as defined by AHRQ. Obfuscation is more likely from research that is less than adequate­—manipulated—or from a news outlet that gets a large portion of its advertising from the medical industry.

Just recently there was an article in the New York Times suggesting that people are unnecessarily taking more vitamin D. Dr. JoAnn E. Manson is quoted in the article as saying, “A lot of clinicians are acting like there is a pandemic” of vitamin D deficiency. There is a pandemic, as in the US alone, Dr. William Grant has shown there are 400 thousand premature deaths just from cancer, diabetes, and heart disease that could be eliminated if serum vitamin D was raised to 45 ng/ml. Grant has done similar studies for other countries with similar results. The article goes on to say that it is about the money that the vitamin D promoters are getting. Wow, I haven’t received any money for writing this blog. The amount that I have received does not even cover the cost of the domain.

This leads us to many studies done to show that vitamin D has no effect in the treatment of the same diseases stated above. It should be interesting to note that in these studies, they always talk about dose and not what the serum vitamin D is. One study suggested that “large doses” of vitamin D had no effect on cancer. It turns out that their large dose was 100,000 IU (2.5 mg) given once per month. This works out to an average 3,300 IU per day. The body operates better with a daily dose instead of one large dose in a month. This amount is not near enough to get the population to a serum level above 40 ng/ml. It would take a daily dose of well over 10,000 IU per day to get ninety-five percent of the population above 40 ng/ml. Also, taken one time a month instead of once per day is not the same affect. Here is a story of one cancer survivor.

So, what does go on about vitamin D and other minerals for that matter? It is about the money. The money that the medical industry makes from a chronically ill population. Researchers have hidden the benefits of vitamin D so that they could make vitamin D analogs for large incomes from the sale of these drugs. At the 2010 Food and Nutrition Board on vitamin D and calcium, there was a consultant and a member of the board that owned patents on vitamin D analogs and were promoting the manufacture of such drugs. (Links from this post are now broken as that was eight years ago.) This conflict of interest is in strict violation of the National Academy of Science policy for ethics.

The holding out of benefits, of vitamins and minerals in adequate amounts, by the medical industry is a slap to the face of the Americans that have paid for the research. One of my pet peeves are biologic drugs or biosimilar drugs. Biologics are made by taking a known cell line, adding large amounts of vitamins and minerals in a reactor, and extracting the desired protein or amino acid. This then becomes a patented drug that is sold for large amounts of money. The drug my have serious side effects. Why not just give the patient the vitamins and minerals and let the body make its own repair compounds? “it’s the economy stupid.” –Pandemic Survivor

Metadichol and Glucose Transport

Once again Dr. P. R. Raghavan has demonstrated how Metadichol works to improve health. In a recent paper, published in the Journal of Stem Cell Research & Therapy, Metadichol is shown to affect the glucose transporter 4 (Glut4 – found primarily on muscle cells) and associated receptor substrates. This explains the control of glucose in patients treated with Metadichol in many case studies.  “Umbilical Cord Treatment with Metadichol, IRS and Glut4 Expressions and Implications for Diabetes” Link to Paper as PDF: IRS-GLUT4-PAPER

It is important to understand that this is a new paradigm for treatment of disease. Typically, in medical treatment research, it has been “one drug–one target.” In the above paper, it is shown how a new understanding of treatment is obtain with “one drug–multiple targets.”  When gene expression as well as nuclear receptors are brought into proper communication, amazing things happen.

Glucose transporters have been shown to increase the transfer of sugars through cell membranes in several ways. Of course, insulation regulation has always been the obvious control of sugar uptake by cells. It is also well known that exercise significantly increases the action of Glut4 which is the transporter for muscle cells. In addition, thyroid hormones play an important role in glucose transporters (which means that iodine and selenium are important). Now for the first time, the regulation of glucose transporters is shown to be affected by a food substance.

Metadichol is a nano-emulsion of waxy aliphatic alcohols, policosanols. The difference of Metadichol and other policosanol supplements is the small particle formulation. Policosanols can be found in many plants. Modern processing of foods has significantly changed the way our bodies take up policosanols. The most concentrated areas of policosanol are on the surface of leaves and husk of seeds and grains.

This is exciting news for diabetics who may be able to control their blood sugar with a substance that does not have side effects, Metadichol. 

 

References:

Glucose Transporters–Wikipedia

Signaling Mechanisms that Regulate Glucose Transport

Glut4–Wikipedia

Glucose Transport Pathway

Metadichol Paper for Skin Repair

In February, I posted about the effectiveness of Metadichol for skin repair.  You can find that article here. It is amazing how it healed my skin without forming a scab. The healing occurred very quickly. Dr. P R Raghavan has published a new paper about skin. “Metadichol® and Healthy Skin: One Approach Many Possible Cures.”  It is published in the Journal of Clinical & Experimental Dermatology Research: Raghavan, J Clin Exp Dermatol Res 2018, 9:1.  Here is a link to the paper-PDF:Metadichol-Skin-applications

From the Abstract
Metadichol is the first molecule to successfully navigate around the problems involved with promiscuous ligands and targets. It fulfills the goals of the emerging field of Polypharmacology i.e a single drug is able to bind to multiple targets beyond the “one drug, one target” concept. We show how Metadichol is an innovative treatment for treating multiple skin diseases like eczema, acne, diabetic wounds viral and bacterial infection and improving skin texture. Metadichol ® is a safe nontoxic low-cost solution and is an alternative to numerous clinical candidates in combating over 3,000 skin diseases.

Don’t let the science of the paper prevent you from accessing the paper. It shows many pictures of skin disease from baseline to healing.  These are amazing pictures and well worth the time to review. In the paper, Dr. Raghavan describes the many drugs that are currently being used to heal skin. These drugs are designed for one drug, one target. Dr. Raghavan shows how Metadichol binds to multiple targets using links-and-connections diagrams. This action of binding to many targets explains how Metadichol acts to provide quick healing. With about 3,000 skin diseases, it is astounding how one compound can heal multiple diseases

Here are a couple of pictures of my own healing from the February post, article here.  I just don’t have the words to express my delight in how Metadichol works. Here are the many articles that I have posted on Metadichol.

Sep 20A1cSep 27A1c

Calcium—An Extremely Important Mineral

calciumIn the minds of most who are concerned about health, calcium is important for building strong bones. Generally, the physician does not explain all that calcium does in the body. We are told that calcium plaque is very dangerous, but we are not told how calcium plaque forms. We are told that cholesterol is the reason for blocked arteries. Really? Strong bones are used as a storage place for calcium as well as to support our structure. Calcium acts in almost every biological activity in the human body. That is the reason that our calcium is controlled in such narrow limits within our blood.

Calcium is required for every thought you make and every action you take. When neurons fire in your brain, signal muscle contraction, or sensory feedback, calcium is required. The signal travels along the neuron to the neural head through the action of voltage potential, sodium, and potassium. Before the neurotransmitters are released to carry the signal to the next neuron, a voltage gated calcium channel opens to allow calcium to flow into the cell. This fact has allowed the creation of a calcium channel blocker, gabapentin (brand name Neurontin). This drug was originally used to stop seizures. It was later used to blunt the action of pain signals. In blocking the action of the neuron, it slows done all neural response. Because the drug was used as an “off label” to block pain and not approved as such, the manufacturer was fined both in the US and the EU. A second drug, pregabalin or Lyrica, was patented and approved for pain reduction and to prevent seizures.

When I was in significant back pain, tramadol was prescribed. Because the pain was not being sufficiently blunted by tramadol, gabapentin was also prescribed. I was able to function well, with pain, with the tramadol. When gabapentin was added, I felt like tar flowing uphill on a cold day. The first experience with gabapentin was slow speech. My trainer sent me home because I was slurring my words. After two months on gabapentin, I had to drink fourteen plus cups of coffee just to function. It not only blocked pain, it blunted all neural action. I got off the drug. There are many other side effects of this drug.

The narrow range of calcium in the blood also has the important action of maintaining a proper acid/base balance. Without a proper acid/base balance, the proteins in our blood tend to fold. This causes loss of the oxygen carrying ability of red cells. It also causes other proteins to not respond for proper biological action.

Secondary signaling is also a very important action of calcium. Before proteins and enzymes are formed, calcium plays an important role. Calcium floods into the cell initiating the RNA/DNA response for the formation of important proteins and enzymes. The RNA/DNA response also includes cell division. Without this signaling, our biology would fail.

How is calcium controlled in our body? There are multiple mechanisms that must be supported by nutrients for proper control of calcium:

  • Vitamin D acts to allow increased calcium absorption in the gut. In the parathyroid gland, parathyroid hormone (PTH) is produced to increase calcium absorption from the gut or from our bones if we are not consuming enough calcium in our diet. If we are not consuming enough calcium, osteopenia and osteoporosis will occur. This is the start of bone loss and other assorted problems like calcium plaque forming in our arteries. Blocked arties and osteoporosis seem to go together. There has not been a single case of secondary hyperparathyroidism when the blood serum level of 25(OH)D, a marker for vitamin D sufficiency, is above 40 ng/ml. Two studies of research literature have shown this.  Secondary hyperparathyroidism is when your parathyroid becomes over active and causes your serum calcium levels to go into a high danger zone. The typical response of modern medicine is to remove several of your parathyroid glands.
  • Loss of proper gut bacteria causes the loss of the important vitamin K2. Vitamin K2 acts to move calcium to the proper locations in our body. It has been shown to reduce calcium plaque in the arteries. It has also been used in Japan for osteoporosis as a prescription drug. Typically, we need vitamin K2 at a rate of about one thousand micrograms per day. Vitamin K2 must be produced in the gut or supplemented. Fermented foods as well as probiotics are known sources of restoring and maintaining our gut bacteria. Properly maintain gut bacteria allow the formation of many nutrients and helps maintain our immune system.
  • When our calcium level starts to go too high, calcitonin is formed by our thyroid glands (or bodies on the thyroid gland). Calcitonin acts to replace calcium in our bones. It is important to keep a healthy thyroid gland. Health of the thyroid is related to how much iodine is consumed. The US government recommends that we only need 150 micrograms per day. This is significantly lower than the consumption of the Japanese population. Studies have shown that typical consumption in Japan is five to fifteen milligrams per day or approximately one hundred times more than the US recommendation. Dr. David Brownstein in his book, “Iodine: Why You Need It, Why You Cannot Live Without it,” suggests that we need a minimum of 12.5 milligrams (combination of iodine/iodide) per day or more if there are serious thyroid issues. I do this either with the supplement Iodoral or Lugol’s solution.
  • Vitamin A is also very important. In my reading of the literature, I am now of the understanding that we do not produce vitamin A from beta-carotene until we are already deficient. This is the body’s mechanism to keep us alive. The importance of vitamin A with bones is the differentiation of bone and cartilage stems cells. It acts in combination with Vitamin D for form a dimer for the differentiation. I supplement vitamin A by taking cod liver oil as a liquid or capsules or eat a piece of beef liver every three weeks.
  • Collagen is also very important in the formation of bone and cartilage. We typically got this protein from bone gravies. It was suggested many years ago that we should stop eating gravies, the drippings of skin and bone when cooking meat, because there was too much fat. The mass hysteria about overconsumption of fat has led to increased consumption of sugar. Sugar stimulates insulin and havoc occurs in our bodies. Reduction or elimination of sugar and flour is also important to bone health.  Are you starting to see how this is all interrelated? To get enough collagen, I put one to two teaspoons of just plain gelatin in my morning coffee. Bone broth is also a good source of important proteins. Vitamin C and magnesium also act to help us form collagen in our body.

Mineralization of our bones not only requires calcium but also magnesium. There are many other minerals that act in the formation of our bones. Primarily, this is through the action of enzymes. To be sure that I am getting enough of these micronutrients, I take a multi-mineral each day. The multi-mineral also supports my calcium requirement. The requirement for magnesium is 3.5 to 4.5 mg per pound of body weight per day. Magnesium supplementation should be done with a chelate of amino acids and not as magnesium oxide. We do not absorb magnesium oxide, and you are just wasting your money if you use magnesium oxide as a supplement. Also, magnesium is a natural calcium channel blocker and should be taken in the evenings to support sleep. Magnesium requirements.

This is a long post and somewhat complicated. However, to not allow our biology to move calcium around properly through consumption of the proper nutrients is the first step toward your grave.          –Pandemic Survivor

Metadichol and Skin Repair

In last post, we discussed the advantages of Metadichol in stem cell development. I suspected several years ago that somehow Metadichol works differently to aid in the repair of skin tissue. In this article, I will show two examples from my own experience with skin repair.

Case 1–A cut from walking in the woods

I took a walk through some very thick woods in September 2016. I received a cut on each arm from snags in the woods. The long cut was bleeding badly. Remembering that policosanol is on most sun-splashed portions of plants, I chewed up some white oak leaves and placed the chewed leaves on the cut. The bleeding stopped almost immediately. I’m not sure why the chewed leaves stopped the bleeding. It was something that we did as children on the farm. I knew that it would work. 

Sep 20A1cHere is a picture of the cut the next day. As you can see it had started to heal. I had treated it with Metadichol spray when I got home that night.

I continued to treat it once a day, and here is the result after seven days. As you can see in the photo, the cut is very nearly healed. There was no soreness during the treatment period. It is interesting to note that no scab formed on the cut. Sep 27A1c

Since I had a cut on the other arm that was not as significant, I decided to treat it with triple antibiotic ointment. I treated it with the ointment on the night that I came home. Here is a picture on the next day. Sep 20B1c

I continued to treat it once a day with the triple antibiotic ointment. Sep 27B1cThere was significant soreness that continued throughout the seven days. Here is a picture of the result. As you can see, the scab is still in place, and there is some healing. I started treating it with Metadichol, and it healed in several days. 

Case 2–A burn wound that was not healing

August 28A friend of mine contacted me in August 2015 to say that she had a burn on her finger that was not healing.Sep 3 I am not sure how long it had been since she had the burn. She said she had been to a doctor, and he gave her a steroid ointment. I gave her a bottle of the Metadichol and suggested that she spray the wound with one spray twice per day.  She said she no longer used the steroid ointment.

Sep 7Here are pictures of the wound from day one, day six, and day ten. It is amazing how the wound progressed to healing from day six to day ten. She called me to ask if she should break the blister on day six. I told her that I did not think that was a good idea. The day ten photo speaks to the accuracy of this suggestion.

As you can see, my experience with using Metadichol for skin repair is significant. –Pandemic Survivor

Enhanced Development of Stem Cells with Metadichol

3D Stem CellsMy first experience with Metadichol was the quick healing of a wound. A wild cherry tree had fallen in the woods behind my house. I had sawed the tree into fire size logs and stacked them in a pile. As I threw one of the logs onto the pile, it caught the back of my hand and caused a two-inch-long cut. I treated the cut with the Metadichol spray. The healing took place twice as fast as my normal experience with cuts. I suspected then that somehow stem cells must have been increased or differentiated or both by the Metadichol for the quick healing (A future article will show two examples of healing with Metadichol from my personal experience.) Dr. P. R. Raghavan has had research done by Skanda Labs to show that stem cells are increased in umbilical cord blood when treated with Metadichol.

The research paper, Metadichol and CD34 Expression in Umbilical Cord Blood, is published in the Journal of Stem Cell Research & Therapy on January 29, 2018. CD34 is a marker for the action of stem cells in many types of cells within the body. During the study, an increase of CD34 protein was shown with the application of Metadichol. Injection of CD34 enriched hematopoietic stem cells have been clinically used for treating spinal cord injury, cirrhosis and peripheral vascular disease. Link to paper as PDF: Metadichol-CD34

There are many types of stem cells within human biology. The two basic classes are embryonic stem cells and adult stem cells. The ability of Metadichol to enhance the development of and the differentiation into a variety cells is critical to healing. This may mean that Metadichol can be used in many different cases of disease to promote healing. Metadichol is simply a nanoemulsion of policosanol or a food substance. Policosanol is a waxy alcohol that is found of many plants which we use for food. There are no known side effects with the food, policosanol.

Science is now using genetic manipulation to help in the development of stems cells. The result is the possibility of rejection of the developed cells and serious side effects. Destruction of cells in the attempts to heal cancer has required the replacement of healthy cells. This has been done typically by using the person’s cells and genetically manipulating them and replacing them in the body. Earlier and current attempts in replacing cells have been done through transplants from donors as in bone marrow transplants. Also, cord blood is now being frozen by some for future use in healing because of the concentration of stem cells.

This is very exciting news. The development of a natural substance used for healing confirms the fact that “Food is medicine and medicine is food.” Thanks for reading. –Mark Pegram

Other Post (22) on Metadichol: https://pandemicsurvivor.com/category/metadichol/

Resources and Useful Links:
http://learn.genetics.utah.edu/content/stemcells/scintro/
https://www.eurostemcell.org/cord-blood-stem-cells-current-uses-and-future-challenges
https://www.scientificamerican.com/article/for-which-diseases-or-con/
https://www.viacord.com/treatments-and-research/treatable-diseases-today/