Heart Disease and Diabetes

As you may already know, the insulin surges that occur when you are diabetic cause a significant amount of plaque to build up in the arteries.  It seems that insulin surges for whatever reason are the cause of this unfortunate course of the disease.  There is hope however that this does not have to be the course of the disease.

You can read the paper, “Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol” by Heaney et. Al with an explanation of how blood sugar and insulin is blunted once your serum 25(OH)D is above 32 ng/ml.  It is an open source paper and I would suggest that you read the full paper if you are diabetic or at least have your doctor read it. From PubMed

Also ‘The Vitamin D requirement in health and disease’ by Dr. Heaney.

Dr. Joe Prendergast of California has a long time practice of endocrinology.  He has treated many diabetics and has had great success in reducing the amount of heart disease in his practice.  Dr. Prendergast discovered in the early nineties that he had a significant amount of heart disease.  His father had died at an early age of this disease.  He decided that he was going to do all that he could not to follow the same course.

He contacted Dr. Victor Zhu who is was head of research at that time at Stanford University to see what he was doing about heart disease.  Dr. Zhu set him up with one of his research fellows that was testing mice with arterial plaque.  Dr. Prendergast decided that he was going to try the same course of treatment that had proved to clear the arteries of the mice.  After a number of years he was imaged again for another purpose and it happened to be the same radiologist.  The radiologist discovered that Dr. Prendergast arteries were clear.  They checked to be sure that the patient file had not been substituted that indeed it was Dr. Prendergast that showed no arterial blockage.

Dr. Prendergast who was at one time head of the board of endocrinology for California decided that he was going to treat the diabetics in his practice.  He has treated over 4000 patients.  The heart disease had reduced to such a low rate in the small city between San Jose and San Francisco that the three man cardiologist practice closed and move to another town.

It seems that he treated his patients with a combination of vitamin D3 and l-arginine.  As you may know there was a Nobel Prize for Physiology or Medicine 1998 awarded for the understanding of the communication pathways for nitric oxide, NO, and how through its signaling pathways it affects the function of the arterial wall cells.  This is what happens when heart patients take nitroglycerin.  However the NO is released in a lower amount when using l-arginine.

It would seem that with such success that this practice would have been adopted by all the doctors treating diabetes.  The vitamin D3 does it thing with the genetics, insulin control, blood sugar control, and the all the other good benefits.  Dr. Prendergast has even written a book about his success in using nutrition with his patients, “The Uncommon Doctor.”

But you know, you do not have to take my word for it.  The owner of Apple Health, David Stouder, was so fascinated by the number of people that were coming to his store to buy vitamin D and the success that they were having in the course of their disease that he decided to interview Dr. Prendergast.  You can go hear the interview at the website set up specifically for that purpose.  www.nutriphobia.com (writers note October 17, 2009 – Unfortunenately this interview has been taken down and I was unable to find it on the new website.  Here is his video comment at youtube )  The first six audios are simply about overcoming the fear of vitamin D and the button ‘click to hear Dr. Joe Prendergast’ is the audio interview with Dr. Prendergast and the above story.  I know that if I were diabetic, I would have my doctor get in contact with Dr. Prendergast for a consult at his practice Endocrine Metabolic.

If you have heart disease or diabetes I would certainly hope that you would spend some time in reviewing this understanding and get your doctor involved.  It is not only your life but it is the life of each patient that your doctor chooses to treat.

In the main time – GO INTO THE SUN!  – Pandemic Survivor

Genetic, Epigenetic, and Vitamin D3

Researchers clear your minds as this is the opportunity for new novel designs for preventing and healing disease.

Note 1.

Dr. John Cannell of the Vitamin D Council says that Vitamin D3 targets over 2000 genes or about 10% of the genome.  We have long thought that we are predisposed to get this disease or that disease because our genes were pre-programmed.  We have thought that the genes were responsible and this is correct.  But in the human body it is not only that the genes exist, it is whether it is turned off or on.

Not being hampered by an education in the biological sciences I can freely speculate about how this happens.  We too often are so tied into how a certain thing works.  Our models that we have created in our minds become permanent fixtures. This may or may not be how a process actually presents itself.  Science has had a long history of confirming a certain theory only to find out later that there is more or worse it is not even close to being accurate.  However, the theories that we have developed allow for many wonderful outcomes.

This is the case with genetics.  It is my belief that everybody has a reasonably reliable gene map.  That is; it is capable of given you a healthy life.  Something in our environment has allowed this gene map to be turned off/on.  Genes are almost ‘digital’ in this matter.  Only on occasion do we have a part on gene and part off gene.  Or some cells may be turning on a gene and others may be turning off the same gene or a ‘fuzzy logic’ sort of action.  This happens in tumors where the immature cells continue to grow and their program to stop growth does not act for apoptosis or programmed cellular death.

The genes are present so you cannot really say that we are genetically predisposed.  What has happened is that either because of the stress of the environment or the diet that we consume has had a significant impact on our genes.  Yes there is imprinting from parent to child, but can that be affected by our present environment and our diet.  Evidently this is how the vitamin D3 works.

Here we introduce epigenetics as a way to turn off and on genes.  Epigenetics time line can be seen at this google page where a history of our understanding of this science is displayed.  We see that most of the work in this science did not start to happen until the twenty first century.  We mapped the genome and found that we could not with certainty say that this gene caused a certain happening.  The gene existed, but it was whether it was turned off/on.  This control ‘above genes’ is known as epigenetics.

This idea about how our environments stressed us and our diets affected us in this manner was promoted in a book by Bruce H. Lipton, Phd ( you may find his work here: http://www.brucelipton.com/) called ‘The Biology of Belief’.  Now this was too far out for most doing research in the biological sciences because they had always believed that if the gene existed it would give you a certain result.  It is like saying that because you have a light bulb with power attached that you will have light without consideration for whether the switch is turned off/on.

Some years ago Dr. Randy Jirtle at Duke University starting doing work with twins to try to make some sense of biology versus nurture.  His discovery was that it is both.  You can find out more about his work at this PBS Nova Science Now website.  There is a short video describing his findings.  Be sure to watch one of his researcher’s ‘Tale of Two Mice’ in the middle of the page.  In brief what they found was that by feeding the mother certain nutrients that they could make the offspring either thin with a brown coat or fat with a gray coat.  I am like the fat mouse with the gray coat.

This lead to the discovery that bisphenyl-a or BPA could give an undesirable effect.  Many recent news articles have been published about how BPA would affect your baby.  Here is a recent article form the Chicago Sun-Times. If the bottles that you were using had this form of plasticizers then you could expect a not so good effect on you child.  I believe that by now all of the baby bottle manufacturers have voluntarily removed BPA as they were most likely concerned over the liability.

If you would like to read more about Dr. Randy Jirtle’s work you can find it at his geneimprint website. Also here is his Duke web page for the researchers. It has a brief description of the current work on carcinogenesis.

It seems that methylation or the binding on the surface of genes by methyl groups (free radicals) keeps the genes from expressing themselves for your health.  There are some great images from ‘A Tale of Two Mice’ above that clearly show how this works.  Now some genes we want turned on and some we want off.  In the case of the mice it was a ‘fat gene’ that was staying on constantly.  By feeding the mice methyl donors, the gene was forced off. This seems like a very precarious balance that we need to negotiate.  After all in the press we read about how ‘free radicals’ are really bad for us but in some cases it appears that they are a necessity.  I would suspect that when you are eating the right things this ‘fat gene’ gets turned off and tells the body to not eat any more food.  I also suspect that the mounds of junk food that we eat do not have the right kind of methyl donors.

Now Dr. Cedric Garland and Dr. John Cannell (Newsletter on Vitamin A) have both expressed concern over too much Vitamin A as they believe that it somehow ‘blinds’ the receptors for vitamin D or VDR’s. Dr. Cannell thinks that taking any preformed vitamin A may give you a problem.  He thinks that people should only get their vitamin A from carotene and let the body make whatever retinol and retinoic acid that it needs.  I do not believe this is the case.  This gives me a real disconnect when you read articles about how too much beta-carotene is not good if you have prostate cancer and lung cancer.  This most likely is because vitamin A and vitamin D are antagonist and they deplete each other as the body is using them for health.  Without enough vitamin D to balance the A the cancer gets worse.

During the healing of my vertebral disc, I found that by taking vitamin A from fish liver oil that the cartilage healed quicker.  I had my major increase in height where I actually grew an inch and one half (a sign of healing vertebral disc) in three months when I started taking this form of vitamin A.

I had found from the Oregon State Micro Nutrient center; and from this article from Japan;  that vitamin A and vitamin D worked together for cellular differentiation of chrondrocytes or the cells that form cartilage.  There were many more articles but these two will get you started.

It seems that dimers are formed from the large family of retinol receptors or RXR and vitamin D receptors or VDR.  Also I found that retinoic acid receptors, RAR, and thyroid receptors, TR, work in synergy for cellular differentiation as well. I also started a seaweed supplement for iodine for a healthier thyroid.  If you chose to read more then you may find a paper on this understanding at the Journal of Biological Science, Nuclear Import of the retinoid X receptor, the vitamin D receptor, and their mutual hetrodimer.

So where does this lead us.  Given the body of work by the many scientists on how vitamin D prevents so many different diseases, I propose that vitamin D3 is the ‘master switch’ of epigenetics from nutrients.  It acts like a shepherd in allowing the body’s various hormones to act for your health.  Genes that need to be on get turned on and genes that need to be off get turned off.

The new body of research and drug development for treating various diseases should be pointed toward the combination of nutrients for healing.  I know that the work will most likely be pointed toward drugs and we will just have to read the research to find out what combination of foods will give us health.  After all, our system of medicine is about treatment, the money that results, and not prevention.  However, now that we know the ‘master switch’ or vitamin D3, we can start down the road to health.

I have not lost the weight even though vitamin D3 has a significant effect on blood sugar and insulin which are some of the controls for appetite.  I am that fat gray mouse.  What are those methyl donors -give me some of that!  Somehow I need to overcome the ingrained statement in our family at dinner; ‘Now I need just a little something sweet.’  I suspect that this saying is gene imprinting from my mother-in-law.  Don’t worry; she does not have a computer.  Our environment and how we perceive ourselves and our needs definitely affect our genes.

Get rid of all the bad carbs, eat more good fats, be sure to get enough protein, eliminate the artificial sweeteners because we do not have a clue, and GO INTO THE SUN. 

– Pandemic Survivor

1. Okay researchers, how are you going to make some sense of the combination of nutrients?  I do not think our present statistical method for evaluation of combination of factors will get the job done.  I know that we have forever been using analysis by the variance.  This type of model requires way too much data to determine what is happening with certainty and really does not point to which factor and their interactions that gives you the result.  In manufacturing, I learned a method of analysis of the means which allows you to use small data sets of 3 to 10.  It will plainly show which factor causes what result and more importantly the interaction of the factors and results.  This interaction is what is extremely important in epigenetics. ANOM has been shown by many scholarly papers to be as precise as AOV.  Ellis R. Ott, (ASQ bio) developed ANOM for his work in military and industrial applications which require much accuracy before making a process change.  You can learn the method from his book: ‘Process Quality Control’.  This graphical method will point you to the correct solution without headache.  I am sure that it is available from Amazon as well.

The Legal on Vitamin D

You would think with as much solid research as there is on vitamin D that the attorney’s would be ‘jumping right in’ there.  What is up with this.  It is about the money.  As soon as someone with money figures out that companies and institutions need to pay up for their misadventures, the courts will be ‘slammed’ with cases on vitamin D.  I mean just think about the tobacco issues.  It only really involved cancer and perhaps heart disease.  It did not involve all chronic disease.  When this starts to happen there will have to be congressional action to save the medical profession.  Of course now congress will not take action to save you from some really serious diseases.

So what has happen with the legal.  What I know to date:
In 2001 the FDA and FTC got together and took on the sunscreen and sunblock industry to get them to change the rules of marketing after combining 9 lawsuits.  It seems with the INCREASE in skin cancer by about a factor of X4 since the 1960’s that the sunscreen industry was participating in false advertising.  The marketing changes would have been to assure that the consumers understood that there was really no science to support the industry claims of preventing cancer.  This really seems odd that we would let a judge decide something scientific instead of just letting the facts be the facts – oh yeah, there is money involved.

So the sunscreen industry formed a powerful lobby group and hired a powerful attorney and sucessfully defected the FDA and FTC.  This attorney was so good that he was later made Chief Justice of the Surpreme Court.  Yes, that’s right Chief Justice John Roberts.  Wall Street Jounral Law Blog comment.
Now if I were an attorney and wanted to start a large class action lawsuit that would most likely end up in the supreme court and may take as much as a decade to litigate would I want the final decision maker to have been on the payroll of the group that I was fighting against?  Sounds like ‘trouble in river city’.

Now there is a new suit that was filed in the spring of 2006 agaisnt this same bunch of snake oil producers.  “Sunscreen is the snake oil of the 21st century” says Samuel Rudman filing attorney for the plaintiffs.  That is really some strong language which I think is justified when we are just causing death with many diseases by chasing people out of the sun.

You know what I really think is interesting is that you can go to the store and get a bottle of sunscreen today that has no warning label at all and says that it will prevent cancer if you use it.  The warning label should at least say something like: 

WARNING: THIS PRODUCT PREVENTS THE FORMATION OF THE MOST ESSENTIAL SECCOSTEROID OF THE BODY AND WITHOUT THIS VITAL STERIOD YOU WILL DIE FROM ONE OR MORE OF ALL THE CHRONIC DISEASES THAT INCLUDE THE BIG THREE KILLERS – HEART DISEASE, CANCER, AND DIABETES.

This would better describe the reality of what the product does to you.  In all seriousness, even if the science is confounded which it is not, the label should read that the sunscreen product will prevent the production of vitamin D.  This would at least allow the consumer to make his own decision.

You know it is really interesting that there were not any cohort studies on the tobacco issues.  It was just ‘good men’ doing what was right for you.  Oh yeah, and government stepping in and taking a piece of those large margins made from selling tobacco products.  There have been a large number of cohort studies completed in the last decade on vitamin D and chronic diseases and the research continues to come in at multiple of thousands of new studies every year.  It is a mountain of evidence.

Lawyers are really just waiting for prior case law to be complete so that they will not have to battle.  They will simply walk in and take the spoils from your dying friend or family or from your death.  What a great land of scavengers for profit that we live in.  It is no wonder that people yell that captilism is not the right form of government when the real issue is that our institutions are being corrupted for money that is just like a third world country with a flair for class.

I have the will but not the money.  Is there someone out there that would like to start a legal fund to take on the largest institutions in the land for their misadventure of ignoring the science for profit?

GO INTO THE SUN!!!   – Pandemic Survivor

Brigham and Woman’s Study on Vitamin D

Well it looks like the NIH is finally taking this vitamin D thing seriously.  Harvard Medical School and Brigham and Woman’s Hospital are to enroll 20,000 people in a study taking vitamin D3 at 2,000 IU per day and fish oil for omega three fats.  Twenty five percent of the people in the study are to be black.  You can read the AP article here.

I believe the level of supplementation is less than half of where it should be, but this is enough to start to see the effect on chronic disease.  The real issue is that it will take several years into the study to start to see that the nation as a whole should be supplementing.  The question for you is that if it does no harm why wait until the study is complete to get your serum level high enough to where it will do some good.

The serum level should definitely be above 40 ng/ml of 25(OH)D and to get the best effect in the body it should be above 70 ng/ml.  The NIH fact sheet (Table 1) says that harm does not start to occur until it is above 200 ng/ml and animal studies show that below 400 ng/ml is safe.  This gives you a safety factor of at least 3 which is much better than most any prescription drug.

The thing that is really troubling to me is that many of the participants will be given placebos with no vitamin D.  I will pray for these people that they do no die from this continued deficiency of this vital steroid.  Hopefully as positive results are shown that the placebo group will also be given vitamin D.

If you decide not to wait because you already have one of the many chronic diseases from vitamin D deficiency then do what it says on the Vitamin D Council home page.  The volume of research is already HUGE and why we need another study is beyond me.  We have already done this the first part of the 20th Century when everyone was taking 2 tablespoons of cod liver oil, about 2600 IU of D3, per day without harm.  The only issue was that the vitamin A level may have been too high in the cod liver oil.  Look at the volume of research by disease at this Vitamin D Council Research Page.

I have been reading extensively on roles of vitamin A and how it interacts with vitamin D.  How these two act in synergy is still not complete science, but I do feel much better when I eat liver or take about 4000 IU of vitamin A from fish liver oil.  I will blog about this in the near future.

Here are the many diseases:  17 varieties of cancer as well as heart disease, stroke, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle wasting, birth defects, periodontal disease, and more.

Why wait!?  It is your health and your life – be healthy!   The encouraging thing about this pandemic is that the news of vitamin D is moving very fast through word of mouth and blogs like this one.  We should start to see things like the overall rate of cancer start to reduce significantly as more people take it on themselves to supplement.

Go into the sun!!!  The best time is between 11AM and 2PM when the UVB radiation is at it highest.  Wear the least amount of clothes possible so that you do not get locked up and if you start to turn pink it is time to get out of the sun and wait until the next day.  As you start to tan it will take longer and only about 15 to 20 minutes to start depending on skin color will be long enough.  – Pandemic Survivor

Michael Jackson, Farrah Fawcett, the Sun

I speculate here and believe that the obituary of Michael Jackson and Farrah Fawcett should read:

“After years of compliance with the institutional norm of avoiding the sun for a beautiful complexion, Michael and Farrah succumbed to  chronic disease from vitamin D deficiency.  May they always be remembered for their art and artistry.”

If they had followed the instructions of Dr. John Cannell of the Vitamin D Council’s home page, I would imagine that they would have lived a much longer productive life.

Thank you John for helping me understand and not falling to this end.  This has allowed me to begin a life of poetry and art.  The poem below would not have been possible without life.  How much art have we been denied from Michael and Farrah?               – Pandemic Survivor

Bondage

Somehow bound up in this world,
We find ourselves trying to make a life
And not just live another existence.

But where do we find the boundaries
For this to allow peace of mind as we
Try to create our worlds?

Boundaries, what are those things that can
Take life away as well as bring life
In abundance to each being that understands?

Boundaries improperly defined
As shackles bind us in a darkness
That can only be compared to slavery.

Oh God, raise up this wretched bound soul
Swirled in desperation of time not spent
In defining bounds of my purpose in life.

Copyright ©2009  Mark Pegram

Black People, White People, the Sun

So once again we have found that black people have been discriminated against because of their skin tone.  It has been known since we started keeping statistics on disease and skin color that people with dark skin have more chronic disease and shorter life expectancy.  I have asked black people why they thought this was and the response was because they believe the stress of discrimination and an overall lower standard of living because of their suppression which lead to reduced medical care.  When I have asked white people what they thought I would get the response that black people just did not take care of themselves.  It seems that none of us are free of bigotry.  Neither answer is even close to correct.

The true reason for much higher disease states is the physical fact that skin color has evolved over time so that we can more easily live with the amount of sun that we would typically get at that latitude.  You can see what this looks like from the skin color map of indigenous people.

As you move away from the equator skin color of indigenous people gets lighter so that they can make an adequate amount of vitamin D.  As you go toward the equator, the skin tone gets darker to protect the skin from the damage of UV.  It then follows that if you have light skin and move closer to the equator that you take a higher risk of skin damage from the sun.  If you have dark skin and move further away from the equator you take the risk of not making enough vitamin D for a healthy long life.

So let’s take melanoma for an example.  Should we expect to find the melanoma rate higher at the equator or at the higher latitudes?  If it was totally from exposure to the sun then you would expect to find higher rates along the equator.  With our very mobile world people with light skin at the equator would have an extremely difficult time with this disease.  However, this was not the case with the data from Edward Gorham, PhD et al in the presentation Skin Cancer\Sunscreen – the Dilemma.   What we see on page five is that as you go away from the equator melanoma gets worse.  So what is going on?  What is even more of a dilemma is that we see that the rates for Argentina are much lower than they are for Australia even though we found that the skin color of the indigenous people were about the same at the same latitude.  Could it be that the cause of a higher melanoma rate is because of an intense program for sunscreen use in Australia?  It is complex and complicated because you also have to consider ozone.  Watch the video: Skin Cancer/Sunscreen, the Dilemma.

It seems that as skin tone gets darker that it takes more time in the sun or a more intense sun for the body to produce the same amount of vitamin D.   For example a person with a light skin tone may take only 15 minutes to produce 10,000 IU of D3 and a person with dark skin at the same latitude and sun intensity it could take 3 to 10 times longer to produce the same 10,000 IU of D3.

With this being the case and low supplementation then it stands to reason that lower vitamin D levels will lead to more disease.  Low levels of vitamin D have been correlated with the ‘big three’ killer chronic diseases: diabetes, heart disease, and cancer.  Dark skin people have a higher incidence of chronic disease.

Our response to this understanding as a society has been alarmingly slow because of our bigotry.  Consider this article Racial Opportunities – about race from Dr. John Cannell at the Vitamin D Council and this civil rights complaint that was filed with the DOJ against the FDA and was refused to be heard by the NIH in 2005.  What are we to think?

In 2005 and 2006 I went to see my local congressman and wrote to the NAACP twice to try to get some help in having the complaint heard.  My congressman told me that there was nothing that he could do about it and the NAACP did not respond to either of my letters.

The research on chronic disease and skin color is being published at an every increasing rate.  Consider this paper just published earlier June.

Differences in Vitamin D Levels Likely Explain Ethnic Differences in Incidence of Congestive Heart Failure

William B. Grant, PhD ; Archives of Internal Medicine Vol. 169, No. 11, June 9, 2009

Let’s get healthier, give up the agendas, and embrace the light.

Boundaries improperly defined
As shackles bind us in a darkness
That can only be compared to slavery     – Pandemic Survivor

Health Care Crisis Solution?

If you just read my most recent post you know how I feel about the solution to the high cost of health care and no insurance for 47 million Americans.  It is at least a disaster that is only going to get worse if we don’t act and I heartily agree with President Obama on this point.  I however disagree that spending more money for health care coverage is the right approach.  I think that healing the population of chronic disease is the correct approach.

Let’s think about the numbers for a moment as it seems to be a lot of misunderstanding and an unwillingness to just simply tell the people what is happening with the cost of health care.  If we think of the insurance industry as any other business then you would expect about 40% external cost and 40% internal cost and then a 20% gross margin that would include in it general, selling, and administrative(where the executives big bonuses come from).  What are the external costs for the insurance industry?  It is the payment to the medical providers as doctors, medical facilities (like hospitals), pharmaceuticals, medical devices, and any other insurance coverage that is provided.  The internal cost is the salary and wages of the employees and agents that handle your coverage and general maintenance cost of large facilities as we know theirs are the biggest.  The gross margin provides for the GSA as shown above leaving about an 7-9 percent margin.

This should make you a little bit perturb as you begin to realize that you get back only about 40 cents on a dollar that you spend for health care as insurance and you protect this industry by allowing some unusual rules like intrastate commerce only and policies that will not follow you around the country like say auto insurance.  Also you are not involved in the payment process of negotiating what actually gets paid to the medical provided.  The insurance companies lump bills together and then beat up the medical providers by saying look how much volume of business we are doing for you.  So the retail bill that you see from the medical provider is not what the insurance company pays.

So what is this in dollars?  I do not know if we have reached 2.5 trillion yet but we have to be close.  So we will use this number as it gives us easy math.  This number represents about 18 percent of the US GDP so 2.5/ 0.18 = 13.8 trillion for the US GDP.  We find from Wolfram Alfa that the US GDP estimate for 2007 was 13.78 million so we most likely have a close estimate for the medical economy.  The world GDP for 2006 in US dollars was estimated at 46.66 trillion.  So our medical economy represents 2.5/46.66 x 100% = 5.36% of the worlds economy.  Now since we have only 306 million out of 6.7 billion people, I would say that we are rather ‘hoggish’.  We are spending 2.5 trillion / 306 million about 8200 USD per capita for health care.  If you take the worlds GDP and divide it by the population or 46.7 trillion / 6.7 billion you get about 7000 USD per capita.  That means we are spending more on healthcare than the average of total per capita spending for the rest of the world.  I would say that it is really hoggish!

If a single payer plan was implemented then we could eliminate about half of the total cost and get it more in line with say Canada (US costs x2 of Canada’s) or Great Britain (US cost x2.5 Great Britain’s).  However, this would cost us about 5 million medical insurance jobs. I just do not think we have the political will for that in the current economy.  If you think about how much money your senators and representatives take from the medical industry to get re-elected, I would say that President Obama is going to have a ‘tough row to hoe’ as we use to say on the farm.

So what would happen if we had a healthy population and the system remained the same?  Let’s say that we could reduce chronic disease by 50%.  Chronic disease represents about 70% of our health care cost.  This would give us about a 35% reduction in total health care cost.  Are these numbers any good?  Let’s see what Dr. William Grant has to say in his work, ‘Reducing the Burden of Disease Through Adequate Intake of Vitamin D3’ for presentation at the UCSD, April 9, 2008.  We find that he picked a multiple of chronic diseases but not all and estimated a reduction of 366, 000 deaths and a reduced medical cost of 199 billion dollars.  He has estimated about a 20 percent reduction so I am not too far off but I am sure he has been more conservative than what will really happen considering my experience with D3.

So this gets even stickier as we consider the lives of hundreds of thousands of people every year.  If you want to put it into a 10 year perspective that would be about 3.4 million people dead and unnecessary spending of 1.9 trillion dollars ( to put that into the total including insurance it would be 1.9/40% = 4.75 trillion). Interesting enough this would just about cover the increased cost of insuring the uninsured according to the Obama plan.   Now it is not medical insurance people that are losing jobs but also medical professionals because total disease has been reduced.  We have not considered here the amount of increased productivity from a healthy population which I am sure would be significant or the cost of supplementation with D3 which should be about 7 billion USD per year.  Ah, if you were president what would you do?

I know that I would go for healing the population and let the economic numbers fall where they may.  We did not give much credence to tobacco jobs because of the bad actions that industry took neither should we give credence to the medical industry because of their bad actions of ignoring the facts.  The improved outlook of a healthy population would overcome any downturn in the reduced medical economy.

You know, I have ignored the abuse of not using available technology in the energy area for years as I knew it was about maintaining the existing ‘cash cow’.  It appears now that energy can be had with the cost of capital.  There was no death involved just more spending for energy than was necessary to generate a big economy.  However, with the death and tortuous pain that millions suffer we most act and not ignore the medical facts.

We are just getting past the reticule stage and starting to enter the violent opposition stage of change so be prepared!  I just cannot wait until we say it was self-evident!

A Survivor of ignoring the facts – go into the sun and be healthy!

The Change of the Medical Landscape in the Next Ten Years

I submitted the below solution to an Innocentive challenge over a year ago that was sponsored primarily by medical insurance institutions as a way to immediately control cost.  I got a nice thank you from Innocentive and of course I did not win the challenge. I imagine that it was frightening to them to think that the medical economy could be reduced by at least 30%.

If you are a medical insurer, health provider, government, or a pharmaceutical manufacturer you will should have great concern when you read this message.

Note, I am neither a doctor nor a nutritionist.  I am just someone that discovered a 99% correlation between obesity and central air condition in the US over the last 20 years.  When I started looking for cause and effect I found sunshine.  I was healed of degenerative disc disease, severe sleep apnea, and after having two back surgeries I avoided three more. All of this healing and reduced medical cost in just four years. My physician tells me that I now have the health of a 25 year old and that is not too bad for a 57 year old man.  This was accomplished by simply supplementing with 4000 IU per day during the summer and 10.000 IU per day during the winter (body weight 230 lbs – 38 degrees North Latitude).  Without this understanding I would be either incapacitated or dead.

For 70 years now we have been ignoring the advantages of the sun or being replete in Vitamin D.  It is even longer if you consider that Niels Ryberg Finsen was given the Nobel Prize in 1903 for curing a form of TB (lupus vulgaris) using UV light.  It is amazing that we started to implement the understanding during the first part of the 20th Century by having the medical profession encourage everyone to take cod liver oil everyday.  We then discovered synthetic steroids in the fifties and the desire for profit and allopathic medicine outweighed our desire for individual health and preventative medicine.  We then entered the years of sun phobia and the entire population became less healthy and is kept alive with modern medicine.  This is great for the medical economy but poor for the individual health.  Our institutional ignoring of the facts has lead to the second ‘Holocaust’.  Sorry to use this word, but I just do not know what else to call it after personally suffering 25 years of torturous pain and loss of income.

The simple solution to improve health care is to heal the population.  The majority of chronic disease can be significantly reduced by changing the health policy of supplementation of vitamin D and the medical guidelines for treatment.  That is to encourage the population to get at minimum 3000 IU (adults) of D3 per day either through supplementation or exposure to the sun or other UVB light source with an upper limit of 10,000 IU per day.  The medical guidelines should be changed to assure that deficiency begins below 40 ng/ml of serum 25(OH)D3 and insufficiency below 60 ng/ml.  Normal range should be changed to 60 to 100 ng/ml for 25(OH)D3 instead of the current 20 to 100 ng/ml.

The present resistance is that there is not enough research to support such a change.  I say that this is just wrong as we have already had a public policy that was close to this when the medical profession suggested that everyone take two tablespoons of cod liver oil per day or approximately 2600 IU of D3.  It is interesting to note that in 25 years in suffering back pain and other disease that not one single doctor suggested that I might vitamin D deficient when we have a national health policy of supplementing milk for bone disease.  How easy is it to ignore the facts when there is no profit motive?

Given the antiviral, antibiotic, antifungal, cellular differentiation, other genetic signaling, autoimmune disease, hypertension, muscle strength, stimulation of the entire endocrine system, and cancer treatment and prevention, the medical industry will most likely shrink by 25 to 50 percent over the next ten years.  As the centers of cash flow change there would be a huge shift in the centers of economy.  The medical economic segment would shrink from first to about somewhere in the middle of the pack.  This would cause great economic concern over a 10 to 20 year period but would significantly improve the productivity and economy of the individual as the population became healthier and in general and an improvement of the economy of the whole.

I know that your goal is to significantly improve medical cost while not impacting medical income.  The question that you have to ask yourself is the health of the individual more important than the medical economy.  So far lobbying efforts have held government policy in check as is readily confessed by HHS Secretary Levitt in his number four principle of “Markets before Mandates”.  It is interesting to note that to “Value Life” is number nine.

You will not be able to stop the growing health benefit of this understanding.  Given that the medical publications are already making their way through the general population anything that you do to slow it down will make you look like perpetuators of the second ‘Holocaust’.  If you take only cancer and consider Lappe, et. al. study from Creighton University June 2006 that showed a reduction in total cancer of 60% when supplementing with only 1100 IU per day of D3, it becomes clear the ramifications of taking policy action.  If policy action is not taken soon the courts will become jammed with tort liability cases against the institutions of health and lead to economic failure in that manner.

Conclusion: Policy Change and Implementation by the US Government on Vitamin D

I will not list resources in this summary as it would take at least 10 pages.  However, please consider the Expert Opinion Diagnosis and Treatment of Vitamin D Deficiency by J. Cannell, B. W. Hollis, M. Zasloff, and R. P. Heaney.

Go into the Sun as I see a bright future in your life!

Toxicity of Vitamin D

This is my own opinion about toxicity and how we got to such a state as the doctors were trained to fear vitamin D.  It seems there are multiple areas where mistakes were made about the issue of toxicity.

I think that one of the issues that everything that resembled vitamin D was called vitamin D.

There is D2 or ergocalciferol which is made from fungus when it is irradiated with UV light. This version has a higher molecular weight, an additional double bond, and one additional methyl group if that means anything to you.  The medical professionals still considers this as equivalent to D3 even though there have been many papers saying that it does not act the same in our body.   Rodents seem to thrive on vitamin D2 as they are noctournal animals and eating fungus that has been exposed to sunlight seems to be a reasonable way for them to get vitamin D and their bodies have adapted.  I observed a squirrel just really munching down on what I assumed was a morel mushroom this past weekend when I was camping.

Hey researchers! – beware when using rodents for vitamin D test as they most likely do not react the same as humans.  The case against using ergocalciferol  (vitamin D2) as a supplement – Houghton and Vieth American Journal of Clinical Nutrition, Vol. 84, No. 4, 694-697, October 2006th

There is D3, cholecalciferol, which our body produces from the sun with cholesterol in our skin. Our bodies love this particular version of D and it is the substance in our bodies that allows the sun to give us energy and health.

There is the storage form prehormone of vitamin D which has been found to correlate with lots of chronic diseases.  It is called twenty-five hydroxy vitamin D and you usually see it written 25(OH)D.  It can be either 25(OH)D2 or 25(OH)D3.  This adds to the confusion when running test in the lab.  Let’s say that a hospital runs only the test for 25(OH)D2 becuase that is what is being prescribed by their doctors and yet ignores the 25(OH)D3 that you are getting naturally.  The better lab test will give you total and I will write another blog on testing.

Certainly if you take the activated steroid form of vitamin D or one twenty-five di-hydroxy vitamin D (1,25(OH)2D) then you will have problems if the dose is too high or administered over a period of time.  This is yet one more form of vitamin D that the body uses as a steroid to do all the good stuff.   This form in the blood stream allows our body to absorb more calicium and will ultimately drive your serum calcium too high.

The really cool thing about the understanding of the new research is that each organ cell seems to make the steroid version inside and outside the cell as it is needed.  This means that it does not go through your blood and affect your calcium yet it gives you healthy functions.  This is one of the things that has always confounded the research as researchers were going right for the best benefit or so they thought by using the steroid form of D instead of given just plain old D3 and letting the body make the steroid as it was needed.

The old paradigm was that the D3 was converted in the liver to the storage form, 25(OH)/D3, and then the kidney converted the 25(OH)D3 into the steroid form, 1,25(OH)2D3 and is still a valid path.  However, when every cell that has vitamin D receptors converts its own steroid form as needed most excellant health is achieved.  You have to have enough of the D3 in your body to fill up the stores.

Well let me stop here and say that this is most likely very confusing to you and has confused the medical field also.  You should go read at the Pharmacology of vitamin D at the Vitamin D Council to get a better description.  You can also read at the University of California Riverside as well about Vitamin D.

The amount of vitamin D is also a really large issue because it is active in extremely small amounts.  Now lets see, the serum test for 25(OH)D is measured in ng/ml.  We take D3 is in units of IU where 40 IU equals 1 microgram – that’s mircogram not milligram.  I suspect you are just conformtable using milligrams and do not have a clue about a microgram much less nanograms per milliliter. So to get 1 milligram of vitamin D you would need to take 40,000 IU.

Are you confused yet.  To formulate and to test at these extremely small quantaties is extremely difficult and one major lab has alreadly had a recall this year because of this difficulty.  So that brings us to the one major case of toxicity with vitamin D3.  It was a formulation problem and a mistake on how much should be taken by the person doing the supplementation.  Evidently the person was taking over a million IU per day for over a year. It is my understanding that he recovered and was just fine.

To get more of an understanding on toxicity of D3 please visit the Vitamin D Council’s page on toxicity.

So what is the deal and why were doctors told to be extemely concerned about toxicity with vitamin D?  It seems that D2 drives toxicity much quicker at lower levels in humans than D3.  I found a paper by Moon and Reich at the Orthomolecular library entitled “The Vitamin D Problem An Important Lesson in Orthomolecular Medicine.” This paper was written in 1975.  These writers researched the issue of toxicity and found that reports started p0uring in after vitamin D2 began to be used.  This particular section in the paper is well titled: ‘Origin of the Vitamin D-Problem:  Irradiated Ergosterol is Not Vitamin D’

Irradiated Ergosterol was origianllly used as the fortification of milk.  However, in the 50’s and early 60’s most dairies changed to D3 because of the toxicity issues.  During my early reading I was finding compounds that were in equilibrium with D3 as tachysterol and ichysterol but D2 seemed to have one called toxicysterol.  This should have been a clue.

If all of this was known at least by the mid 70’s why all of the fear of D3.  Because D2 and D3 were considered to be equivalent by the medical profession.  I would say that this is terrible science or chosen to be ignored by the medical profession because there was no money to be made. Interestingly enough, D2 is what is found in vitamin D prescriptions because it can be protected because it is not a natuarlly occurring substance in the body.  You could not obtain D3 in beneficial amounts until a few years ago.  To get equivalent to one day in the sun where your body could make as much as 40,000 IU as a supplement you would have to take 100 of those 400 IU tablets.

I was curious as to a statement made by Hector DeLuca in his presentation to the Wisconsin Alumini Research Foundation on Vitamin D: The New Old Wonder Drug.  This you tube video gives you the understanding of how vitamin D analogs have been very sucessful in helping to fund the programs at Wisconsin University.  The statement that some of the beneficial findings over the years were not published is frightening.  This of course was to protect intellectual property rights or dollars.

So does ignoring the facts for profit make the medical profession seem somewhat callous?    It happens all of the time and you acting as the government protect these profits to the loss of your health and life.  Consider former Secreatary Leavitt of Health and Human Services.  On his bio page he listed his priorities.  Number four was ‘markets before mandates’ and you had to go to his last to find ‘value life’.  Now this is really troubling since I was tortured with pain for 25 years when there was a simple solution.

So is it going to far to say that by scaring people out of the sun and causing a significant increase in chronic disease that we were benefiting the well being of America because of an increased medical economy?  Creating disease by selling sunscreen and profiting from the meds to treat the diseases is for another post.

Go into the Sun until you start to turn pink.  Being in the pink is a good thing!