Human Production of Vitamin C

Human C

I had reported early the finding of Dr. P. R. Raghavan for increased levels of vitamin C in diabetes cases when treated with Metadichol. (Metadichol Induces High Levels of Vitamin C) It appears that the increase was activation of the gene responsible for making the enzyme necessary for the completion of vitamin C production.  This was based on the findings of Dr. Raghavan’s gene studies. This is true in animal studies not yet proved in Humans as the GULO gene is non-functional. Does Metadichol activate the dormant GULO gene in humans despite it being mutated? Studies provided by Skanda Life Sciences shows that Metadichol does activate the gene responsible for the missing enzyme in mouse studies. “Metadichol, Vitamin C, and GULO Gene Expression in Mouse Adipocytes” Link to PDF Metadichol-Vitamin-C-Gulo The loss of production for vitamin C in humans and not in other animals is a mystery.

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Vitamin C is so important to immune health that without it we would soon die of scurvy. Sailors in past centuries developed the disease because of the lack of fresh vegetables and fruits. The British used limes to provide vitamin C and the Germans used sauerkraut (Thus, the associated nicknames). Recently a physician in Norfolk Virginia found that he could treat septic shock (deadly blood infection) with vitamin C, thiamine, and hydrocortisone. The physician has had only one death after treatment of 150 patients. This shows the significance of how important vitamin C is to the immune system, and may explain how Metadichol works so effectively on so many different diseases.

Metadichol boosts the immune system in many other ways. One of the more important ones is how it affects the action of the vitamin D receptors. The vitamin D receptor acts like a conductor of the orchestra for other nuclear receptors. One very important action of the receptors is the making of antimicrobial peptides that are killer cells for all pathogens. Vitamin C supports many of the functions of neutrophils. Neutrophils (white blood cells), another important immune system function, ultimately converts to various types of killer cells that hunt down pathogens.

Vitamin C also has a role in stem cell production as well as collagen folding. This makes Metadichol very significant in wound healing. Treating and preventing infection and acting in wound repair. It is truly amazing how this one substance can act in so many ways. Collagen is useless without folding of the molecule. Because of the folding of collagen, vitamin C is also very important for building strong bones. Thanks for reading­­–Mark Pegram

More Resources:

https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
https://www.nature.com/scitable/topicpage/the-mystery-of-vitamin-c-14167861
Effects of Vitamin C on Neutrophil Function: https://www.ncbi.nlm.nih.gov/pubmed/17235150
Other articles about Metadichol and research papers: https://pandemicsurvivor.com/category/metadichol/  

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The Onslaught Against Nutrients for Bone Health

BoneRecently there have been many articles about the ineffectiveness of vitamin D and calcium for bone health.  Major media outlets that published about the ineffectiveness of vitamin D and calcium for bone health include: ABC news, Reuters, WebMD, Newsweek, LA Times, and Washington Post. I am sure there are more. Why this onslaught on vitamins and minerals?

My personal experience has been significantly different. This includes the recent discovery that my right leg length returned to normal after many years of supplementing with vitamins and minerals. Article It is interesting to note that the IOM (name changed to National Academy of Medicine) reported that we only need 600 IUs of vitamin D3 for bone health in 2010. The IOM took the position that the amount was so small as it was only about bone health. The importance of calcium is that every cell starts biological action with calcium and vitamin D3 controls calcium. It was reported three years ago that an error in the statistics was made by the IOM. The actual amount should have been over 7,000 IUs per day of vitamin D3. The error for the wrong amount of vitamin D was heavily reported in the Canadian press, but not one single major US news outlet reported the error.

I believe we don’t only have a case for fake news. I believe that news about how vitamins and minerals are significantly important for health has been intentionally held from press. The reason is the number of health ads for pharmaceuticals and allopathic treatment are the major source of income for news outlets. Consider this recent post by Grassroots Health about how the cost of health is significantly reduced with higher levels of vitamin D. What if we had an adequate amount of all the right types of nutrients. I believe that healthcare cost would be reduced by fifty percent. This would effectively send us into a depressed economy as approximately twenty percent of GDP is from healthcare.  

What can we do about this? I have tried with congressmen and the response was tepid at best. Government does not want to take the chance that the economy would fail. I understand the need for robust economy and engineered failure. This occurs in everything from auto batteries to your iPhone that is slowed down when the new model is available. But to support the economy off the illness of the population may just be evil. How much lost production do we have from illness? I suffered back and joint pain for three decades to discover that modern medicine was not offering what was available in the science that we had paid for as tax payers.  The real science for nutrients is just being ignored, or worse, being manipulated for the economy. 

Bone health does not only require vitamin D3 and calcium. It also requires the combination of many nutrients that include vitamin D3, vitamin A, vitamin B, calcium, magnesium, boron, vitamin K, iodine, and proteins from animal bones and skin. Iodine is another nutrient in which seventy-five percent of the population is deficient based on present recommendations. If we consume the amount that is present in the Japanese diet, then we are off by a factor of one hundred. The modern paradigm for bone health is to just take a drug, bisphosphonate. This supports the economy but may not do much for your health.

The best solution for your chronic disease is to do your own research in nutrients. The institutions will not be much help as they want to maintain a strong economy. Thanks for reading. –Pandemic Survivor

Adenovirus and the Common Cold

Adenovirus and the Common Cold

Adenovirus is a virus that presents itself like flu or colds. It also can lead to very serious lung infections as the immune system is suppressed. There is no vaccine available to the general public. The US Army has a vaccine available to immunize its solders. 

From the CDC: Adenoviruses are common causes of respiratory illness, but most infections are not severe. They can cause cold-like symptoms, sore throat, bronchitis, pneumonia, diarrhea, and pink eye (conjunctivitis). You can get an adenovirus infection at any age, but infants and people with weakened immune systems are more likely than others to develop severe illness from adenoviruses.

The problem for older adults with weakened immune systems is that could lead to pneumonia. I know of two people locally that have been hospitalize after starting with what just seemed like a cold. Adenovirus appears to be prevalent throughout the southeast. This particular version of adenovirus presents itself like symptoms of the flu or a severe cold.

To help keep your immune system up during the flu and cold season, I would suggest you read my several posts on viruses and the common cold. https://pandemicsurvivor.com/2014/10/24/treating-and-preventing-viral-infections/ and https://pandemicsurvivor.com/2012/03/30/vitamin-d-the-common-cold-and-rhinitis/ and https://pandemicsurvivor.com/2014/10/27/how-mom-and-dad-dealt-with-flu-and-colds/

In these posts, you will find that large amounts of vitamins A, D, and C in combination with zinc is the best solution. –Pandemic Survivor

Hope for Psoriasis

Nanoscience has brought new hope for psoriasis. There have been many treatments available for psoriasis through the years. Now an over the county supplement has brought a solution. Metadichol is an over the counter supplement that is simply policosanol made into a small particle emulsion. Policosanol is the waxy substance found on the sun-splashed parts of plants. The case studies in this new paper that was just published are amazing in how it resolves the issues around this disease that has no apparent resolution in modern medicine.

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Raghavan PR* Nanorx Inc Chappaqua, New York, United states

Abstract

Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate.

The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz® that blocks IL17 for treatment of plaque psoriasis.

Metadichol® a nano-formulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.

This paper is published in the Journal of Clinical & Experimental Dermatological Research. Citation: Raghavan PR (2017) Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis. J Clin Exp Dermatol Res 8: 433. doi:10.4172/2155-9554.1000433 This is an open access journal.  Link Prr-Psoriasis-paper

Most diseases are connected through a network that is commonly called network pharmacology. The paper shows how Metadichol affects many different diseases through this network. It is definitely worth your time to look at the paper. Presented are seven case studies with psoriasis resolved. Picture here is whole body psoriasis that is resolved in twenty-four weeks. The participants used the spray orally and applied it directly to the areas of concern.

pic psoriasis

Other than Metadichol, I do believe that the over the counter ointment of vitamins A and D is the best. Metadichol appears to work along pathways for A and D.  Typically, vitamins are currently recommended at levels that are to resolve basic body needs without looking at higher levels for improved health.

Vitamin D Day of Seasonal Change

SunWinter in the northern latitudes can be daunting. It is a time when there are more colds and flu. Also, there are many other diseases that take advantage of our reduced immunity during the winter. Chronic disease can make you very painful during the winter. Of course, going into the sun always makes us feel better. But why?

There are so many reactions of our body to the sun. However, since the 1960s, dermatologists have been tricked into constantly screaming about the dangers of the sun. We know that it makes us feel better, but what about our medical industry telling us otherwise? It is a difficult problem to sort out. Do the advantages of sun exposure outweigh the dangers. The answer is a resounding yes.

November second has been declared Vitamin D Day by the Vitamin D Council, Grassroots Health, and the Vitamin D Society. This has been done to promote the understanding of vitamin D and to encourage the use of supplementation during the winter months in the northern hemisphere. Also, to use exposure to full spectrum sunlight when possible. Here is a link to an informational page: http://www.vitamindday.net/

The question of whether to enjoy the sun without fear of causing cancer has become a ridiculous sidetrack in modern medicine. All the energy that is beneficial to our wellbeing comes from the sun. Whether it is the food we eat, products made from plants that are useful like furniture, or the chemical and thermal reactions in our body. Overexposure to anything can be dangerous, but are you going to stop driving your car because you might die in a car accident? Are you going to stop drinking water because overconsumption can dilute out your electrolytes and cause your heart to stop? Wear your seat belt, don’t spend time in the sun without sunscreen, and don’t drink too much water are all the same ilk. It is about the benefit of action versus the risk. Unfortunately, fear can make you have a very unhealthy life if it is over expressed.

Dermatologists are medical professionals specializing in the largest organ of the body. You would think that they would encourage the benefits as well as tell us about the dangers. The dangers have been overexpressed and the benefits not expressed enough regarding sun exposure. So, what are the benefits of sun exposure? There are many healing compounds that are made in the skin. Vitamin D is just the beginning as there are a host of sterols produced with ultraviolet light (UV) exposure that have significant action in our body. Not only was vitamin D discovered from UV exposure, there are many intermediate molecules that are generated. I suspect there are compounds that are beneficial to health from full spectrum sunlight that have not been identified. One area that does not have much study is the conversion of molecular sulfate esters and sterols during sun exposure (If health researchers want an exciting area of study, this is it).

On the other side of the visual spectrum from UV is near infrared light. The science being discovered about how near infrared light improves our health is amazing. To understand, think how good the warmth of sunlight makes you feel on a cold autumn day. It is not just the heat. It is the biological action that takes place in our body. We have discovered that near infrared improves wound healing, shrinks tumors, improves neurological health, increases cellular energy, detoxifies our bodies, and reduces pain.

With so many health benefits, why would you not want to go into sunlight? Is the increase of melanoma that parallels the increase of sunscreen a coincidence? Have our professionals created unintended consequences by inducing fear of cancer from sun exposure? Am I a voice in the wilderness telling you there is health in the sunlight? Medical science changes more than the seasons as it is an art. Let’s celebrate more than vitamin D Day. Let’s celebrate health from the sun. As for me, I’m going to spend time in the sun on this beautiful autumn day. –Pandemic Survivor

Metadichol as Mediator of Inflammatory Response

Note to readers: This article is to notify researchers to the possibilities of Metadichol as a mediator of the AHR-Nrf2 pathway for inflammatory response. Metadichol’s action on nuclear receptors is hugely significant. The importance of Metadichol’s effect is in regulating inflammatory response to outside agents. Outside agents may include drugs, manmade toxins, or even response to light (think sunburn and/or retinal protection). In this paper, it is shown how Metadichol may be significant in treating chemo resistant cancer.

Metadichol ®. A Novel Inverse Agonist of Aryl Hydrocarbon Receptor (AHR) and NRF2 Inhibitor
Journal of Cancer Science and Therapy 

Raghavan, P R
Nanorx Inc., Chappaqua, New York, USA,  

Abstract
Metadichol ® a novel nano-emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2)) and is a transcription factor that is ubiquitously expressed at low levels in all human organs and regulates a primary cellular defense mechanism, tight regulation to maintain cellular homeostasis. AHR is highly expressed in a broad panel of tumors, AHR is induced by 2,3,7,8-tetrachloride-benzo-p-dioxin (TCDD) Metadichol® as a inverse agonist against AHR could be potentially useful in the treatment of such diseases. Strong in vivo evidence suggests that TCDD can stimulate cross-talk between AHR and Nrf2. The constitutive up regulation of Nrf2 signaling appears to drive the cellular proliferation and resistance to chemotherapy in various cancers. Therefore, pharmacological inhibition of Nrf2 by Metadichol ® holds promise as a therapeutic strategy in chemo resistant forms of cancer. 

Here is a link to the PDF: metadichol-AHR-Paper

Terror at the VA

VA HealthThirty months at war in Vietnam. Twenty-three years in the military. The horror of war imprinted in your brain to be replayed at any time. Triggered by almost any incidence, it comes at you like the ballistics at the end of a twelve-inch gun. Emotional trauma so strong the only place you can cope is in the structure of the military. How would you expect to be treated after decades of service protecting your country? You would like to think that our veterans are treated with great dignity and the respect they deserve.

We often hear horror tales of how our veterans are treated by VA Hospitals and healthcare in general. It usually involves waiting times. Recently there was the story of the nurse who was so occupied with a game she let a heart patient die on her watch. I have passed this off as local occasional incidents no different than our accepted medical treatment, but the problem is much more widespread. I got permission from my brother to tell his story of malpractice the VA. He gave me permission if I stick to the facts. I have waited three years to relay this story as he does not want to be bothered with legal action against a country that he fought to protect. Unfortunately, this is not a made-up Halloween story to just horrify you.

It was getting late at night and the pain continued to grow in Brother’s abdomen and radiating to his back. What has happened now? Bad food that has turned his gut up-side-down? Brother decided to return to Fayetteville, NC to make a life for himself after his service. He was never married as he did not want to burden another with emotional trauma delivered by military life. Only supported by a few friends and family members that did not forget him after three decades intermittent contact, he considered Fayetteville a safe-haven because of its military nature. Brother’s temperature had continued to increase over the last hour from 101 to 103. He called his friend Buddy to take him to VAMC emergency department.

After medical personnel had examined him at the emergency room, Brother was told that the pain was coming from a hip that was damaged from combat and military life. He was told to go home, take two aspirin for his temperature, and he would be just fine. Brother knew this was wrong. When you are deathly sick, signals alarm in your body that cannot be ignored. He pleaded with the medical personnel that something was deadly wrong, but they passed him off like a fly had lit on their ham sandwich.

Brother instructed Buddy to take him to Womack Army Medical Center (WAMC) on the Fort Bragg military complex. After emergency medical personnel examined him, he was immediately catharized. He had kidney stones blocking his bladder. The pain in his abdomen was from a swollen bladder that was about to rupture. His temperature spike was determined to be coming from a kidney and urinary infection. After further examination, it was determined that he had pyelonephritis. This deadly disease can kill you within hours or days as the bacteria spreads into your blood stream. He was put on IV antibiotic and kept in the hospital for over a week. Later x-rays showed that he had multiple kidney stones that needed to be removed from his kidney.

If Brother had complied with VAMC emergency, I would now be visiting his grave. Are directions coming from the top that former soldiers are to be managed in a way that fits a budget? Managed in a way that soldiers nearing late-life increases in benefits should be allowed to die to control cost? Is the VA in Fayetteville over-burdened with too many returning soldiers? Are government unions protecting employees to the point that incompetence has become a way of life? Whatever happened to duty, honor, country—General MacArthur is shuddering in disgust. President Donald J. Trump, clean up this cesspool! 

(In research for this article, I found this notice from September 2014 or the period when Brother’s emergency occurred. Get with it Elizabeth Goolsby, Medical Center Director, you’ve got to be better than this. If you are a veteran living in Fayetteville, do not use the VAMC.) –Mark Pegram contact: vitamindmark at gmail