Calcium—An Extremely Important Mineral

calciumIn the minds of most who are concerned about health, calcium is important for building strong bones. Generally, the physician does not explain all that calcium does in the body. We are told that calcium plaque is very dangerous, but we are not told how calcium plaque forms. We are told that cholesterol is the reason for blocked arteries. Really? Strong bones are used as a storage place for calcium as well as to support our structure. Calcium acts in almost every biological activity in the human body. That is the reason that our calcium is controlled in such narrow limits within our blood.

Calcium is required for every thought you make and every action you take. When neurons fire in your brain, signal muscle contraction, or sensory feedback, calcium is required. The signal travels along the neuron to the neural head through the action of voltage potential, sodium, and potassium. Before the neurotransmitters are released to carry the signal to the next neuron, a voltage gated calcium channel opens to allow calcium to flow into the cell. This fact has allowed the creation of a calcium channel blocker, gabapentin (brand name Neurontin). This drug was originally used to stop seizures. It was later used to blunt the action of pain signals. In blocking the action of the neuron, it slows done all neural response. Because the drug was used as an “off label” to block pain and not approved as such, the manufacturer was fined both in the US and the EU. A second drug, pregabalin or Lyrica, was patented and approved for pain reduction and to prevent seizures.

When I was in significant back pain, tramadol was prescribed. Because the pain was not being sufficiently blunted by tramadol, gabapentin was also prescribed. I was able to function well, with pain, with the tramadol. When gabapentin was added, I felt like tar flowing uphill on a cold day. The first experience with gabapentin was slow speech. My trainer sent me home because I was slurring my words. After two months on gabapentin, I had to drink fourteen plus cups of coffee just to function. It not only blocked pain, it blunted all neural action. I got off the drug. There are many other side effects of this drug.

The narrow range of calcium in the blood also has the important action of maintaining a proper acid/base balance. Without a proper acid/base balance, the proteins in our blood tend to fold. This causes loss of the oxygen carrying ability of red cells. It also causes other proteins to not respond for proper biological action.

Secondary signaling is also a very important action of calcium. Before proteins and enzymes are formed, calcium plays an important role. Calcium floods into the cell initiating the RNA/DNA response for the formation of important proteins and enzymes. The RNA/DNA response also includes cell division. Without this signaling, our biology would fail.

How is calcium controlled in our body? There are multiple mechanisms that must be supported by nutrients for proper control of calcium:

  • Vitamin D acts to allow increased calcium absorption in the gut. In the parathyroid gland, parathyroid hormone (PTH) is produced to increase calcium absorption from the gut or from our bones if we are not consuming enough calcium in our diet. If we are not consuming enough calcium, osteopenia and osteoporosis will occur. This is the start of bone loss and other assorted problems like calcium plaque forming in our arteries. Blocked arties and osteoporosis seem to go together. There has not been a single case of secondary hyperparathyroidism when the blood serum level of 25(OH)D, a marker for vitamin D sufficiency, is above 40 ng/ml. Two studies of research literature have shown this.  Secondary hyperparathyroidism is when your parathyroid becomes over active and causes your serum calcium levels to go into a high danger zone. The typical response of modern medicine is to remove several of your parathyroid glands.
  • Loss of proper gut bacteria causes the loss of the important vitamin K2. Vitamin K2 acts to move calcium to the proper locations in our body. It has been shown to reduce calcium plaque in the arteries. It has also been used in Japan for osteoporosis as a prescription drug. Typically, we need vitamin K2 at a rate of about one thousand micrograms per day. Vitamin K2 must be produced in the gut or supplemented. Fermented foods as well as probiotics are known sources of restoring and maintaining our gut bacteria. Properly maintain gut bacteria allow the formation of many nutrients and helps maintain our immune system.
  • When our calcium level starts to go too high, calcitonin is formed by our thyroid glands (or bodies on the thyroid gland). Calcitonin acts to replace calcium in our bones. It is important to keep a healthy thyroid gland. Health of the thyroid is related to how much iodine is consumed. The US government recommends that we only need 150 micrograms per day. This is significantly lower than the consumption of the Japanese population. Studies have shown that typical consumption in Japan is five to fifteen milligrams per day or approximately one hundred times more than the US recommendation. Dr. David Brownstein in his book, “Iodine: Why You Need It, Why You Cannot Live Without it,” suggests that we need a minimum of 12.5 milligrams (combination of iodine/iodide) per day or more if there are serious thyroid issues. I do this either with the supplement Iodoral or Lugol’s solution.
  • Vitamin A is also very important. In my reading of the literature, I am now of the understanding that we do not produce vitamin A from beta-carotene until we are already deficient. This is the body’s mechanism to keep us alive. The importance of vitamin A with bones is the differentiation of bone and cartilage stems cells. It acts in combination with Vitamin D for form a dimer for the differentiation. I supplement vitamin A by taking cod liver oil as a liquid or capsules or eat a piece of beef liver every three weeks.
  • Collagen is also very important in the formation of bone and cartilage. We typically got this protein from bone gravies. It was suggested many years ago that we should stop eating gravies, the drippings of skin and bone when cooking meat, because there was too much fat. The mass hysteria about overconsumption of fat has led to increased consumption of sugar. Sugar stimulates insulin and havoc occurs in our bodies. Reduction or elimination of sugar and flour is also important to bone health.  Are you starting to see how this is all interrelated? To get enough collagen, I put one to two teaspoons of just plain gelatin in my morning coffee. Bone broth is also a good source of important proteins. Vitamin C and magnesium also act to help us form collagen in our body.

Mineralization of our bones not only requires calcium but also magnesium. There are many other minerals that act in the formation of our bones. Primarily, this is through the action of enzymes. To be sure that I am getting enough of these micronutrients, I take a multi-mineral each day. The multi-mineral also supports my calcium requirement. The requirement for magnesium is 3.5 to 4.5 mg per pound of body weight per day. Magnesium supplementation should be done with a chelate of amino acids and not as magnesium oxide. We do not absorb magnesium oxide, and you are just wasting your money if you use magnesium oxide as a supplement. Also, magnesium is a natural calcium channel blocker and should be taken in the evenings to support sleep. Magnesium requirements.

This is a long post and somewhat complicated. However, to not allow our biology to move calcium around properly through consumption of the proper nutrients is the first step toward your grave.          –Pandemic Survivor


Metadichol and Skin Repair

In last post, we discussed the advantages of Metadichol in stem cell development. I suspected several years ago that somehow Metadichol works differently to aid in the repair of skin tissue. In this article, I will show two examples from my own experience with skin repair.

Case 1–A cut from walking in the woods

I took a walk through some very thick woods in September 2016. I received a cut on each arm from snags in the woods. The long cut was bleeding badly. Remembering that policosanol is on most sun-splashed portions of plants, I chewed up some white oak leaves and placed the chewed leaves on the cut. The bleeding stopped almost immediately. I’m not sure why the chewed leaves stopped the bleeding. It was something that we did as children on the farm. I knew that it would work. 

Sep 20A1cHere is a picture of the cut the next day. As you can see it had started to heal. I had treated it with Metadichol spray when I got home that night.

I continued to treat it once a day, and here is the result after seven days. As you can see in the photo, the cut is very nearly healed. There was no soreness during the treatment period. It is interesting to note that no scab formed on the cut. Sep 27A1c

Since I had a cut on the other arm that was not as significant, I decided to treat it with triple antibiotic ointment. I treated it with the ointment on the night that I came home. Here is a picture on the next day. Sep 20B1c

I continued to treat it once a day with the triple antibiotic ointment. Sep 27B1cThere was significant soreness that continued throughout the seven days. Here is a picture of the result. As you can see, the scab is still in place, and there is some healing. I started treating it with Metadichol, and it healed in several days. 

Case 2–A burn wound that was not healing

August 28A friend of mine contacted me in August 2015 to say that she had a burn on her finger that was not healing.Sep 3 I am not sure how long it had been since she had the burn. She said she had been to a doctor, and he gave her a steroid ointment. I gave her a bottle of the Metadichol and suggested that she spray the wound with one spray twice per day.  She said she no longer used the steroid ointment.

Sep 7Here are pictures of the wound from day one, day six, and day ten. It is amazing how the wound progressed to healing from day six to day ten. She called me to ask if she should break the blister on day six. I told her that I did not think that was a good idea. The day ten photo speaks to the accuracy of this suggestion.

As you can see, my experience with using Metadichol for skin repair is significant. –Pandemic Survivor

Enhanced Development of Stem Cells with Metadichol

3D Stem CellsMy first experience with Metadichol was the quick healing of a wound. A wild cherry tree had fallen in the woods behind my house. I had sawed the tree into fire size logs and stacked them in a pile. As I threw one of the logs onto the pile, it caught the back of my hand and caused a two-inch-long cut. I treated the cut with the Metadichol spray. The healing took place twice as fast as my normal experience with cuts. I suspected then that somehow stem cells must have been increased or differentiated or both by the Metadichol for the quick healing (A future article will show two examples of healing with Metadichol from my personal experience.) Dr. P. R. Raghavan has had research done by Skanda Labs to show that stem cells are increased in umbilical cord blood when treated with Metadichol.

The research paper, Metadichol and CD34 Expression in Umbilical Cord Blood, is published in the Journal of Stem Cell Research & Therapy on January 29, 2018. CD34 is a marker for the action of stem cells in many types of cells within the body. During the study, an increase of CD34 protein was shown with the application of Metadichol. Injection of CD34 enriched hematopoietic stem cells have been clinically used for treating spinal cord injury, cirrhosis and peripheral vascular disease. Link to paper as PDF: Metadichol-CD34

There are many types of stem cells within human biology. The two basic classes are embryonic stem cells and adult stem cells. The ability of Metadichol to enhance the development of and the differentiation into a variety cells is critical to healing. This may mean that Metadichol can be used in many different cases of disease to promote healing. Metadichol is simply a nanoemulsion of policosanol or a food substance. Policosanol is a waxy alcohol that is found of many plants which we use for food. There are no known side effects with the food, policosanol.

Science is now using genetic manipulation to help in the development of stems cells. The result is the possibility of rejection of the developed cells and serious side effects. Destruction of cells in the attempts to heal cancer has required the replacement of healthy cells. This has been done typically by using the person’s cells and genetically manipulating them and replacing them in the body. Earlier and current attempts in replacing cells have been done through transplants from donors as in bone marrow transplants. Also, cord blood is now being frozen by some for future use in healing because of the concentration of stem cells.

This is very exciting news. The development of a natural substance used for healing confirms the fact that “Food is medicine and medicine is food.” Thanks for reading. –Mark Pegram

Other Post (22) on Metadichol:

Resources and Useful Links:

Human Production of Vitamin C

Human C

I had reported early the finding of Dr. P. R. Raghavan for increased levels of vitamin C in diabetes cases when treated with Metadichol. (Metadichol Induces High Levels of Vitamin C) It appears that the increase was activation of the gene responsible for making the enzyme necessary for the completion of vitamin C production.  This was based on the findings of Dr. Raghavan’s gene studies. This is true in animal studies not yet proved in Humans as the GULO gene is non-functional. Does Metadichol activate the dormant GULO gene in humans despite it being mutated? Studies provided by Skanda Life Sciences shows that Metadichol does activate the gene responsible for the missing enzyme in mouse studies. “Metadichol, Vitamin C, and GULO Gene Expression in Mouse Adipocytes” Link to PDF Metadichol-Vitamin-C-Gulo The loss of production for vitamin C in humans and not in other animals is a mystery.

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Vitamin C is so important to immune health that without it we would soon die of scurvy. Sailors in past centuries developed the disease because of the lack of fresh vegetables and fruits. The British used limes to provide vitamin C and the Germans used sauerkraut (Thus, the associated nicknames). Recently a physician in Norfolk Virginia found that he could treat septic shock (deadly blood infection) with vitamin C, thiamine, and hydrocortisone. The physician has had only one death after treatment of 150 patients. This shows the significance of how important vitamin C is to the immune system, and may explain how Metadichol works so effectively on so many different diseases.

Metadichol boosts the immune system in many other ways. One of the more important ones is how it affects the action of the vitamin D receptors. The vitamin D receptor acts like a conductor of the orchestra for other nuclear receptors. One very important action of the receptors is the making of antimicrobial peptides that are killer cells for all pathogens. Vitamin C supports many of the functions of neutrophils. Neutrophils (white blood cells), another important immune system function, ultimately converts to various types of killer cells that hunt down pathogens.

Vitamin C also has a role in stem cell production as well as collagen folding. This makes Metadichol very significant in wound healing. Treating and preventing infection and acting in wound repair. It is truly amazing how this one substance can act in so many ways. Collagen is useless without folding of the molecule. Because of the folding of collagen, vitamin C is also very important for building strong bones. Thanks for reading­­–Mark Pegram

More Resources:
Effects of Vitamin C on Neutrophil Function:
Other articles about Metadichol and research papers:  

The Onslaught Against Nutrients for Bone Health

BoneRecently there have been many articles about the ineffectiveness of vitamin D and calcium for bone health.  Major media outlets that published about the ineffectiveness of vitamin D and calcium for bone health include: ABC news, Reuters, WebMD, Newsweek, LA Times, and Washington Post. I am sure there are more. Why this onslaught on vitamins and minerals?

My personal experience has been significantly different. This includes the recent discovery that my right leg length returned to normal after many years of supplementing with vitamins and minerals. Article It is interesting to note that the IOM (name changed to National Academy of Medicine) reported that we only need 600 IUs of vitamin D3 for bone health in 2010. The IOM took the position that the amount was so small as it was only about bone health. The importance of calcium is that every cell starts biological action with calcium and vitamin D3 controls calcium. It was reported three years ago that an error in the statistics was made by the IOM. The actual amount should have been over 7,000 IUs per day of vitamin D3. The error for the wrong amount of vitamin D was heavily reported in the Canadian press, but not one single major US news outlet reported the error.

I believe we don’t only have a case for fake news. I believe that news about how vitamins and minerals are significantly important for health has been intentionally held from press. The reason is the number of health ads for pharmaceuticals and allopathic treatment are the major source of income for news outlets. Consider this recent post by Grassroots Health about how the cost of health is significantly reduced with higher levels of vitamin D. What if we had an adequate amount of all the right types of nutrients. I believe that healthcare cost would be reduced by fifty percent. This would effectively send us into a depressed economy as approximately twenty percent of GDP is from healthcare.  

What can we do about this? I have tried with congressmen and the response was tepid at best. Government does not want to take the chance that the economy would fail. I understand the need for robust economy and engineered failure. This occurs in everything from auto batteries to your iPhone that is slowed down when the new model is available. But to support the economy off the illness of the population may just be evil. How much lost production do we have from illness? I suffered back and joint pain for three decades to discover that modern medicine was not offering what was available in the science that we had paid for as tax payers.  The real science for nutrients is just being ignored, or worse, being manipulated for the economy. 

Bone health does not only require vitamin D3 and calcium. It also requires the combination of many nutrients that include vitamin D3, vitamin A, vitamin B, calcium, magnesium, boron, vitamin K, iodine, and proteins from animal bones and skin. Iodine is another nutrient in which seventy-five percent of the population is deficient based on present recommendations. If we consume the amount that is present in the Japanese diet, then we are off by a factor of one hundred. The modern paradigm for bone health is to just take a drug, bisphosphonate. This supports the economy but may not do much for your health.

The best solution for your chronic disease is to do your own research in nutrients. The institutions will not be much help as they want to maintain a strong economy. Thanks for reading. –Pandemic Survivor

Adenovirus and the Common Cold

Adenovirus and the Common Cold

Adenovirus is a virus that presents itself like flu or colds. It also can lead to very serious lung infections as the immune system is suppressed. There is no vaccine available to the general public. The US Army has a vaccine available to immunize its solders. 

From the CDC: Adenoviruses are common causes of respiratory illness, but most infections are not severe. They can cause cold-like symptoms, sore throat, bronchitis, pneumonia, diarrhea, and pink eye (conjunctivitis). You can get an adenovirus infection at any age, but infants and people with weakened immune systems are more likely than others to develop severe illness from adenoviruses.

The problem for older adults with weakened immune systems is that could lead to pneumonia. I know of two people locally that have been hospitalize after starting with what just seemed like a cold. Adenovirus appears to be prevalent throughout the southeast. This particular version of adenovirus presents itself like symptoms of the flu or a severe cold.

To help keep your immune system up during the flu and cold season, I would suggest you read my several posts on viruses and the common cold. and and

In these posts, you will find that large amounts of vitamins A, D, and C in combination with zinc is the best solution. –Pandemic Survivor

Hope for Psoriasis

Nanoscience has brought new hope for psoriasis. There have been many treatments available for psoriasis through the years. Now an over the county supplement has brought a solution. Metadichol is an over the counter supplement that is simply policosanol made into a small particle emulsion. Policosanol is the waxy substance found on the sun-splashed parts of plants. The case studies in this new paper that was just published are amazing in how it resolves the issues around this disease that has no apparent resolution in modern medicine.

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Raghavan PR* Nanorx Inc Chappaqua, New York, United states


Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate.

The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz® that blocks IL17 for treatment of plaque psoriasis.

Metadichol® a nano-formulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.

This paper is published in the Journal of Clinical & Experimental Dermatological Research. Citation: Raghavan PR (2017) Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis. J Clin Exp Dermatol Res 8: 433. doi:10.4172/2155-9554.1000433 This is an open access journal.  Link Prr-Psoriasis-paper

Most diseases are connected through a network that is commonly called network pharmacology. The paper shows how Metadichol affects many different diseases through this network. It is definitely worth your time to look at the paper. Presented are seven case studies with psoriasis resolved. Picture here is whole body psoriasis that is resolved in twenty-four weeks. The participants used the spray orally and applied it directly to the areas of concern.

pic psoriasis

Other than Metadichol, I do believe that the over the counter ointment of vitamins A and D is the best. Metadichol appears to work along pathways for A and D.  Typically, vitamins are currently recommended at levels that are to resolve basic body needs without looking at higher levels for improved health.