Tag Archives: cancer

Pathogen Uses of Cloaking Devices Disrupted

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Pathogen CloakingIn the much-watched Star Trek program, the dastardly Klingons would cloak their ships so that they were invisible to the USS Enterprise. In the human body, pathogens also cloak themselves to be invisible, seem like sugar or a food, by using sialic acids. Sialic acids are common on the cells of vertebrates and are the highest concentration in the brain. The immune system will not attack pathogens with sialic acid attached because they appear as a natural part of the human system. Dr. P. R. Raghavan has found that Metadichol, by expressing the CD33 gene, allows binding of these acids so that the immune system can disrupt the pathogen.
There have been many papers published on human healing by Dr. Raghavan that include increase in stem cells, reduction of diabetes, and general well being realized with the use of Metadichol. The finding of the binding of sialic acid with the expression of CD33 and the increase in stem cells explains the healing of wounds quickly when using Metadichol.
Below is a recently published paper by Dr. Raghavan on this topic. Metadichol acts to up regulate or down regulate CD33 depending on signaling mechanisms in human physiology.

Metadichol® and CD33 Expression in Umbilical Cord Cells

Abstract
CD33 also known as Siglec-3 is endogenously expressed in stem cells and is a marker for the myeloid lineage of cells. Increased expression of CD33 thus allows it to bind to any Sialic Acids (SIAs). These acids are binding sites for pathogens and toxins. By binding to these acids, CD33 can prevent invasion of hosts by these pathogens. Down-regulation of CD33, increase the release of the pro-inflammatory cytokine TNF-α by monocytes that increases reactive oxygen species that are involved in diseases like diabetes mellitus, Alzheimer’s, cardiovascular diseases asthma, and in various cancers.
     The up-regulation of CD33 using Metadichol® was studied using Wharton’s Jelly Mesenchymal Stem Cells (MSCs) isolated from human umbilical cord and were grown in p-35 dishes until confluent and treatment was carried out with different concentrations. One dish was untreated and considered as control. The treated and untreated cells were analyzed using Flow Cytometry. The cells treated at 100 pg of Metadichol® has shown the highest increase (>400 fold) in CD33++ expression (48.77%) compared to untreated control (0.11%).
Link to paper: CD33-paper
This paper may be difficult to digest. However, that should not stop you from using Metadichol for whatever ails you. This is a link for the 29 articles with links to Dr. Raghavan’s papers that I have published on Metadichol.  –Mark Pegram

Experience of Using Metadichol for Years

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Given that we have become somewhat leery of peered reviewed research papers, especially in the length of time it takes to get the information public, the experience of users may be our best source. Dr. P.R. Raghavan, the discoverer of Metadichol, a patented nutraceutical, gave me introduction to his friend, Dr. Joe Marasco, that has been using Metadichol the longest other than Dr. Raghavan. This first article is about the experience with his family. The next will be about his experience with his pets. The comments are in his words with only few editorial changes. The healing outcomes of Metadichol are amazing. Through word of mouth, this product has the potential to change the health of the world. Be sure to read my other articles on Metadichol by selecting that category. – Pandemic Survivor

Here is a brief Bio: Joseph Marasco, Ph.D.

Joe largeDr. Marasco, CEO of Diffinity Geonomics, is responsible for business development and company operations. Prior to joining Diffinity, he served from 2007-2012 as CEO and board member of Chiral Quest Corp., a US headquartered fine chemical and active pharmaceutical ingredient manufacturing firm. Dr. Marasco has served in several other leadership roles in both early stage and publicly traded firms including Dow Chemical and Beckman. He led the launch of Coenzyme Q-10 as a nutritional supplement in the US during the 1990’s while serving as Director of Kaneka’s pharmaceutical division (the original manufacturer of Q-10). He earned his Ph.D. in organic chemistry from University of Virginia, and was awarded a postdoctoral fellowship in Biochemistry at the Walter Reed Medical Center. 

From Dr. Joe Marasco:

Dr. Raghavan kindly sent me a prototype sample of Metadichol.  I ingested the sample around 6:00 pm that evening, and then commenced to write a report for work, which I expected to have completed in about an hour.  Well, I did finish that report, and went on to another report.  When I looked up from the keyboard, it was morning.  I had worked through the night without realizing it, and actually felt absolutely fine.  I showered, dressed, and headed back to the office for a full day of work again.  It was a feeling of increased baseline energy, not a nervous caffeine or sugar induced temporary rush.  I called Raghu that morning and asked what the heck he had put in that sample!  From that day, I have been hooked on the potential of Metadichol. As a biochemist, although understanding its mechanism of action, I had underestimated its actual effects.

About eight years ago, my father underwent a drastic 14-hour surgery in an attempt to remove as many tumors as possible after being diagnosed with metastatic bladder cancer.  Multiple tumors were removed from several areas of his body, however I was told by the surgeon after the grueling operation that dad had about another three months to live, but with chemo it could be stretched to an unpleasant six months.   He refused chemo, and was basically chair-bound with two ostomy tubes protruding from his back.  However, he lived several more years.  During that time, Dr. Raghavan very kindly sent him some Metadichol.  I would visit my father every other month, as I was living in China at the time.   After a couple of weeks using it, my mother who had been constantly caring for dad called me in China and mentioned that she could not believe the change in his mood and energy level.  From being chair-bound most of his waking hours, he was now outside raking leaves around the yard daily, and actually going for walks at the mall.  When I visited him next, I also could not believe the positive change in his mood.  This alone is a huge benefit to a cancer victim.  Once sullen with chronic pain and discomfort, he was now smiling and laughing easily, and one would have a hard time believing that he was at death’s door not long before.  My mother related to me a stunning comment from his primary physician at the time: they “cannot understand why his several tumors have not progressed.”

Dad continued to take Metadichol daily, until a nurse (who was a relative) found out about it, and ordered him–more like frightened him–into stopping treatment.  Dad died of kidney failure several months afterwards.  (This makes me sad because of the lack of understanding of medical professionals. I have had similar experiences with friends and family in health care facilities -P.S.)

8/20/12
Raghu,

“IT WORKS!!!” screamed my wife….

My wife woke up and shouted for me when I was in the kitchen having coffee and she was up in the bedroom. I thought something was wrong, so I ran up. She had an intense tone to her voice, and she said, “my face is ‘different.’”   She had been using your Metadichol gel for two consecutive nights. “The small bumps on my skin …are just gone! I don’t know what happened, but tell Raghu I want him to stay in business for a lifetime.”

–Joe
9/30/12
Raghu,

Some recent observations regarding the use of Metadichol gel:

  1. Used on my 18-month old rotator cuff shoulder injury. Normal state was a steady-state of chronic pain, worsening to the point where it was challenging to pick up a coffee cup (this coming from a prior background of >30 years of routine daily exercise including weight training, which I had to cease after the injury). Pain seemed to decrease perhaps 10-20% after three weeks of nightly application on affected area of shoulder, and application continued. Several months later, the pain is now minimal.
  2. My wife, an active woman of 57, developed plantar fasciitis, where the heel of her right foot was very painful to walk on, and she had to cancel attending her normal bi-weekly Jazzercize® class after 25 years due to the pain. Nightly application of the gel on her heel has given noticeable relief from the pain, and the difference after the first night’s application was striking.  She resumed the class after 3 weeks of Metadichol gel treatment.
  3. Also now treating my own severe plantar faciitis daily in both feet with Metadichol gel with very good effect. In my own experience, the initial reduction of pain was not as striking as my wife’s, but now after two weeks the pain has subsided noticeably (estimate 50% decrease in discomfort and continues to improve).
  4. My wife has been using the gel on her face for over 2 weeks, and has noticed a rapid definite improvement in skin tone and smoothness, and is now applying the gel to other areas of her body such as neckline and arms.

So, as you might suspect, Dr. Marasco is a huge proponent of Metadichol.  Thank you for reading through his comments. I will post his comments on his experiences with his pets later. He dearly loves his dogs and treats them as member of his family. His comments of his human experience are truly amazing! – Pandemic Survivor

Breast Cancer Survivor Takes on the Issues

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Carole Baggerly had her own experience with breast cancer. She then started to research the reason why. Her discovery; scientists have expressed the understanding that breast cancer is a deficiency disease. That is over her life time, her intake of vitamin D was not adequate. She was so upset and concerned about the issues that she started GrassrootsHealth. This is a consortium of more than forty scientists and doctors that are experts in vitamin D and nutrition. She discovered that it was not only breast cancer, but a host of chronic illness related to deficiencies. Take the time and watch her explain the issues in the first thirty minutes of this video presentation.  Carole Baggerly and Dr. Heaney, September, 2012  Presentation to Direct-MS Canada.

If you are concerned about the health of your children, yourself, your parents, the next hour is Dr. Heaney who has contributed significantly to the understanding of vitamin D. He talks about the longevity issues and decline with chronic disease because of nutritional deficiencies. There are many diseases that have now been linked to deficiencies that number into the hundreds. This is particularly pointed to vitamin D deficiency.

This discussion is fairly non-technical and is understandable by the average person. Dr. Heaney expresses the understanding that “things go better with vitamin D”. That is that vitamin D deficiency may not be the cause of a disease like TB, but not having enough vitamin D will prevent your body from properly healing. However, this understanding falls into the logic of the chicken versus the egg. In other words, if you had enough vitamin D would you have gotten TB in the first place? Dr. Heaney discusses everything from diabetes, heart disease, MS, pregnancy, and cancer to infectious diseases like TB. I give the video presentation six stars out of a five star rating system for understanding of chronic disease and the effect of vitamin D.  Presentation to Direct-MS Canada.

Your take away from this, is you, your friends, and your family should not suffer from vitamin D deficiency.   Standards within the medical industry have long been 20 ng/ml to 100 ng/ml.   There have not been any cases of toxicity below 200 ng/ml or 500 nmol/l.  There does not appear to be any downside at this level of vitamin D.  Some laboratories have decreased the upper number, 100 ng/ml, to whatever they are measuring the population. Best health for you can be reached with a vitamin D serum level, 25(OH)D between 40 ng/ml to 80 ng/ml; note this is still within the normal range as defined by medicine. It is not how much you take; it is where you maintain your serum level. Everyone responds differently to their intake from all sources of vitamin D. The only way to know is to test.  Dr. Heaney says to maintain a level above 40ng/ml will require an intake from all sources of 5000 IU or more of vitamin D3 per day.

Please note this presentation is in Canada. The measurements used are in nanamoles per liter or nmol/l. To convert ng/ml to nmol/l multiply ng/ml by 2.5. So the normal range of 20 to 100 ng/ml is 50 to 250 nmol/l. Get your serum level tested to give your body a chance to thrive. If you choose to do it through GrassrootsHealth, you become part of the study that will help to advance health in the population. – Pandemic Survivor

Test by GrassrootsHealth: banner_ad_long5company postingVideo of how to do the test:  bscvideothumbnailv3web

Higher Vitamin D Intake Drastically Reduces Disease

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A new study of serum levels of vitamin D shows that 4000 to 8000 IU per day are required to keep your serum level in a range that will reduce the incidence of disease. This includes cancer, type 1 diabetes, and multiple sclerosis.  Dr. Cedric Garland says that the incidence of many diseases could be reduced by half.

Here is the news article in Business Week: “Higher Vitamin D Level Could Cut Cancer Risk”

As I have described in many post, the amount of vitamin D required is different for each individual.  The only way to know that you are getting enough is to have your serum 25(OH)D level tested.  Serum levels should be maintained above 40 ng/ml, and for best results the level should be maintained between 60 to 80 ng/ml year round.  You should only supplement with Vitamin D3.

For a better understanding of the science, here is the journal article that was published in Anticancer Research, International Journal of Cancer Research and Treatment, made available in its entirety by Grass Roots Health.

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention

CEDRIC F. GARLAND, CHRISTINE B. FRENCH, , LEO L. BAGGERLY, and ROBERT P. HEANEY (here is the url in case you cannot go there from the above link  http://www.grassrootshealth.net/garland02-11)

“This paper provides a long awaited insight into a dose-response relationship between orally administered vitamin D3 and the resulting levels of serum 25(OH)D in over 3600 citizens. The results will allow new definition of high vitamin D dose safety and reduce concerns about toxicity. This is a landmark contribution in the vitamin D nutrition field!”

– Pandemic Survivor

Millions Needlessly Die of Vitamin D3 Deficiency

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Well, in my satire on the presidential declaration of a national emergency it seems that I got my numbers wrong about the amount of death from vitamin D deficiency.   I had used 400,000 deaths that is an extrapolation used in William Grants paper on what would happen if everyone in the US were to take 2000 IU of D3 per day.  “Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.” http://www.sunarc.org/GrantGrassrootsHealth.pdf Since Dr. Grant wrote this paper that used data from 2001 new research has come to light.

I received an email today from the John Cannell, Vitamin D Council, that said that William Faloon, Co-Founded of Life Extension Foundation, had written a new article with a retraction of his data from the letter of 2007.  http://www.lef.org/magazine/mag2007/oct2007_awsi_01.htm His new numbers that appeared in the January, 2009 issue of Life Extension Magazine shows that there could be well over a million deaths in the US every year from vitamin D deficiency.  http://www.lef.org/magazine/mag2009/jan2009_Millions-of-Needless-Deaths_01.htm

So what are we to believe?  I always like to check my data from an independent source.  If we consider that vitamin D has the possibility of reducing all chronic disease by 40 percent what would that mean for America?  If you will recall my post on Health Care Reform Heal the People we found that the death rate in Mexico is 4.8 per 1000 per year and in the US the death rate is 8.4 per 1000 per year,  or 43% less deaths per year in Mexico.  CIA Fact Sheets:  https://www.cia.gov/library/publications/the-world-factbook/rankorder/2066rank.html So you ask what the disparity of data is.  Do they have a better health care system?  The answer of course is that they are a sun-splashed country in the lower latitudes which means they most likely have higher vitamin D levels than the US.  And not only that,  but much of the population lives above 5000 ft which is above much of the atmospheric moisture and pollutions and this allows a higher incidence of UVB radiation to make vitamin D.  Also their winters are not as cold so more of the human body is exposed because they simply wear fewer clothes.

The death rate in the US of 8.4 minus the death rate of 4.8 is 3.6 per 1000 population per year.  If we take that most of this is from the difference in vitamin D levels then the US could reduce death by 3.6 times 307,000 thousand (307 million US population) per year.  This works out to 1,150,000 people per year.  If we say that there are more deaths because we have more cars and higher incidence of toxins because we are (were) a more industrialized nation, we would still have well over a million less deaths from vitamin D3 deficiency every year.  This would decimate the medical and medical insurance industries to say nothing of big pharma and over-the-counter goods sold at retail as remedies for whatever.  If the deaths are reduced by this much imagine how much less suffering and pain there would be from disease.

This is one heck of a survivor story as Mexico has significantly less death and suffering than the US because of vitamin D3.  I know the above may not be very scientific but it makes a lot of just plain common sense.  Imagine the millions of needless deaths in other countries because of this dread deficiency in a world with a population 6.7 billion people with a large portion living at the higher latitudes.

William Faloon sent this article to all Congressmen and Senators:  http://www.lef.org/magazine/mag2009/jan2009_Millions-of-Needless-Deaths_01.htm

While you are basking in the sun write your Congressman, The President, and the Secretary of Health and tell your friends.    – Pandemic Survivor

Breast Cancer Going Rogue

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Sara Palin does not have a corner on the market for going rogue.  Rogue is an interesting word as my Dad always used it when he was talking about someone that he considered a thief and a scoundrel.  Now it is used to indicate someone that is not holding the ‘party line’.  A better way to state it is someone is telling the truth and to think you have to be outside of the ‘norm’ to tell the truth bodes dread for a society that has gone rogue.

Dr. Cedric Garland and his brother Dr. Frank Garland were telling the truth back in 1980 when they proposed that breast cancer was a result of lack of sun exposure.  This was right at the height of the dermatologist telling us that we would die from cancer if we were exposed to the sun.  Here is one article from December 1990 in the NY Times; ‘Sunlight and Breast Cancer: Danger in Darkness’ Here is an update on the same theme from 2002 in the NY Times: ‘Sunlight, a Cancer Protector in the Guise of a Villain’ This article talks about how the brothers first presented this understanding in 1980.

Here we are with 2009 almost over and 29 years from when the Garland brothers first proposed that lack of sunlight was killing us and our government is still not acting toward the science and much less with compassion toward people that are dying from chronic disease.  How could this happen.  Has specialization so become a bastion of science that we allow evil to flourish.  Who holds the moral compass in our large institutions.  Is it the special interest groups that are just about making profit regardless of what happens to the people that they serve.

Dr. Garland is still singing the same tune but no one seems to be listening.  Such a tragic disease like breast cancer that destroys women’s self image and destroys them with death when the solution is there in the sun is heart wrenching.  Here is a letter to the editor of the NY Times by Dr. Garland saying that the mammogram testing is fine but the real solution lies in getting women vitamin D replete which would eliminate breast cancer.  Here is his open letter:  Mammography or Primary Prevention; An open letter to the NY Times.

In Toronto at a recent symposium on vitamin D, Dr. Garland was so brave as to say that breast cancer could be virtually eradicated with vitamin D.   Eradicate Breast Cancer with Vitamin D? Here we have a doctor that has been studying vitamin D for over 30 years and offers a solution.  What if he is only half right?  Would we still not like to have a 50% reduction in breast cancer?

There is no reason that doctors should let people die when they are vitamin D deficient when there is no harm in having enough vitamin D in your system to be healthy.  In fact it Is difficult to understand when the research on cancer and vitamin D goes back all the way to 1940 and it still has not found its way into general practice.  This has to be more than just ignoring the science.  It is ignoring the science for profit and what would you call that?  Going rogue indeed!

Do not die vitamin D deficient!!     – Pandemic Survivor

Dr. Cedric Garland is a:

Professor
Department of Family and Preventive Medicine
University of California San Diego
Participating Member
Moores UCSD Cancer Center
La Jolla, California

Healtcare Reform – Heal the People

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Sorry to not have posted in a while.  I had vacation and business to take care of.  I am trying to post two to three per week.  Send me your vitamin D3 survivor stories to email vitamindmark@gmail.com.

I have been truly amazed at the amount of misinformation that is thrown about during the debate over healthcare reform.  There are both good and bad parts of the legislation that is being proposed.  I believe that it is good if we can get to a health coverage that takes the enormous profits of the health insurance industry out of play and how the intent to profit negatively impacts health.  I do not believe that the government taking over these profits as another form of tax is proper either. On the other hand the intrusion of government into our private lives can be devastating.

As I was surfing the channels listening to the comments by various ‘news’ channels I found Bill O’Rielly and Dick Morris talking about one of President Obama’s recent speeches on the mater.  They were just about to end the segment when Dick Morris made the comment that Canada’s death rate from cancer was sixteen percent higher than the US.  “Why would we want a healthcare system that would cause this much higher death rate”, he said.  Bill agreed and they ended the segment.  I decided to follow this line of argument.

I found the total death rate from all neoplasms or ‘new growth’ to be 184 deaths per year per 100,000 in the US  for 2005.  From Reuters. I did confirm that that Canada’s death rate from cancer was about 16% higher.  In following the logic of modeling a country with low cancer death rates, I then looked at Mexico.  I found the death rate to be about 90 per 100,000 or about half of what the death rate was for the US.  Article in the Oxford Journals.  This is about half the rate as the US so we most likely would want to adopt the healthcare industry in Mexico?  Dick Morris, get a grip!  Fear mongering is not the answer to healthcare.

I then looked at the death rate from all causes from the CIA  data to follow Dick’s logic in how to discover a healthcare system that is most appropriate.  I found the 2009 est. for the US to be 8.3 per 1000 with a worldwide rank of 102.  I also found the death rate in Canada to be 7.74 per 1000 with a rank of 117 and Mexico at 4.8 per 1000 with a rank of 194.  The highest death rate with the number 1 rank is Swaziland at 30.8 per 1000 and the lowest was the United Arab Emirates with a rate of 2.11 per 1000 and a rank of 223.

Now what are we to make of this?  It is to be noted that the lowest death rates in the world are primarily in countries that are awash in sunshine.  Countries in the Middle East are highly populated in the lower rankings as well as countries along the lower latitudes, closer to the equator, in the world. Swaziland at the highest is totally understandable because it has been devastated with the HIV virus.  It is also the world’s last absolute monarchy which means that if you do not do what the government wants you die.  With the amount of war going on in the Middle East, it is surprising to find the deaths rates so low.  However, think of how these countries have so many days of no clouds and just bright sunshine.

Let’s think about Mexico.  Mexico City has the highest population of any city in the world at almost 9 million.  It is also located at approximately 7400 ft in elevation.  This puts it above a lot of the atmosphere that blocks out UVB waves that generate vitamin D in the skin.  As an aside it was the practice to build solarims for the treatment for TB in the first par of the first part of the 20th Century above 5000 ft.  As we have discussed in other post, vitamin D3 has a vector in the pathology of all disease.  It is interesting that the death rate from the H1N1 virus has been so high in this country.  However, in general as the H1N1 has spread the countries with low vitamin D levels have much higher death rates from this disease.

Could it be that Dick Morris is just wrong in his statement?  I think that the answer is absolutely yes.  What should we do for the health of the population?  The best answer for healthcare reform is to treat the populations of the world with the best available science.  That is to be sure that everyone’s serum 25(OH)D3 level is above 50 ng/ml.  As discussed earlier from a paper by Dr. William Grant of SUNARC.ORG the serum level of people in a sunny country is 54 ng/ml to 90 ng/ml.  This could be done for about $20 dollars per person per year.  What an inexpensive way to improve the health of all people.  For the US this is only 6 billion dollars per year.  I suspect that this is going to be significantly less than we spend on the H1N1 vaccine alone for this year.  It is also just a ‘drop in the bucket’ of that 2.5 trillion dollar US medical economy.  But here lies the problem.  The medical economy could drop by 30% if we healed the population and what would we do with all those lost insurance jobs.  I would not want to be president, but if I were, normalizing the serum 25(OH)D3 level would be the first thing I did.

Spend time in the sun!!!!!!!!!!!!!!  – Pandemic Survivor

Lies, Damn Lies, and Vitamin D

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Where did we go so wrong with sunshine and vitamin D?  Were these just people in the medical professions ignoring the facts as they concentrated each day on how to heal chronic disease?  If they were truly concentrating on chronic disease, why wasn’t the pharmacology of vitamin D studied more for determining how it could possibly help to heal disease?

This is a lot of questions considering the millions of people who have died of these diseases in the twentieth century.  How can we make sense of this without considering that just maybe some misdirection was happening?  In the early forties, one researcher made the statement that the amount of skin cancer that was prevented by staying out of the sun was minor compared to all the other cancers that could be prevented by going into the sun.  What happened to him and why wasn’t this line of research pursued?

Well it seems that there was some fear going on by those who held intellectual property rights to vitamin D and how it could be used to treat disease.  Supplements that you could buy over the counter had been made with extremely small amounts of vitamin D to the point that it was not beneficial for use.  It seems that the manufacturers thought that these supplements would interfere with their sales of prescription drugs.  I suspect there was also the thought that there were other applications like cancer that could be treated and prevented with higher amounts and the dollar signs were going off in their eyes.

The Wisconsin Alumni Research Foundation held the rights to the vitamin D patents and licensed them to anyone who wanted to make vitamin D products.  It seems that they were trying to manage the license to maximize profits without concern of what they were doing to the health of the community.

The government brought suit against WARF and 17 other entities for trust violations on vitamin D in 1944.  It appears that there was ‘arbitrary and unreasonable prices’ and limited the potency of preparations so that it would not compete with their pharmaceutical products.  Now since this was when WWII was raging, I doubt that anyone in the press was paying too much attention.  What were a few kids with rickets not being able to get the vitamin D they needed as opposed to all that was going on with the war?

The settlement in the case happened when WARF turned over the patents for public use.  Here is the headline from the NY Times in 1946:

VITAMIN D PATENTS GIVEN TO THE PUBLIC; U.S. Court Decree Ends Civil Anti-Trust Suit Against Wisconsin Foundation PROHIBITIVE COST CITED Asst. Dist. Attorney Says Persons Who Most Needed Rickets Cure  Were Unable to Get It

Special to THE NEW YORK TIMES
January 15, 1946, Tuesday
Page 16

CHICAGO, Jan. 14–Patents controlling Vitamin D, the so called “Sunshine Vitamin,” which prevents and cures rickets, became public property today when Federal Judge John P. Barnes signed a consent judgment terminating a civil anti-trust suit filed last October against the Wisconsin Alumni Foundation and seventeen other defendants.

You can purchase the article from the NEW YORK TIMES archives.

It seems that this brought an end to the misadventure with vitamin D as far as rickets was concerned.  The patents had become public property so that anyone could make D3 and the market place would make the vitamin readily available to those who needed it.  But then THE LIE began to be perpetuated about how D3 and D2 were equal in the human body in the 1930’s.  This was great news for WARF because they continued to control the rights for many D analogs and perhaps D2 as well.  D2 is not a natural substance in the body as it is made from irradiating fungus.

But of great concern is that the beneficial findings on vitamin D and its effect on chronic disease were not published because WARF wanted to protect its intellectual property.  It appears that letting people die was okay as long as WARF protected its property.  You can hear a recent presentation at youtube where Hector De Luca, professor of biochemistry UWM, describes this very thing.  You can hear how wonderful the drug has been to Wisconsin in funding research but says nothing about how many people died because they did not publish the beneficial findings.  Vitamin D, the New Old Wonder Drug:   Listen to the introduction about how many vitamin D analogs have made life wonderful for millions of people and profited WARF.  It just makes me angry as this protection of an institution for profit brought much disease that led to pain and death to others in not telling how just plain vitamin D3 would get the job done.  All very legal and deadly! It looks like the thing that they were sued for in 1944 is still going on in a different format.

If you really wanted to protect your patents on vitamin D analogs and improve your market size, how would you do it?  You certainly would not want to report how good a job just plain old vitamin D3 would do as this is the least expensive of the supplements on the market.  If people got replete with D and 75% of chronic disease disappeared what would happen to the medical industry?  After all, it has a right to protect itself and its growth.

You know what would really be great for the growth of this industry would be to figure out some way to keep people out of the sun.  If we can’t keep them out of the sun at least figure out a way to prevent the skin from making vitamin D.  Remember that cute little girl with her ‘hiney’ showing bright white as the dog pulled her paints down from the 1960’s?  And here is Plough, Inc. finding a great new market for selling a consumer product that would be really beneficial to millions to reduce burns and prevent skin cancer – sunscreen – the DAMN LIE.

It did prevent sun burns and this was great for the entertainment industry and all the ‘fun parks’ that were being developed because people could stay out in the sun longer and spend more money.  However, since sunscreen was presented in the sixties, the rate of skin cancer has gone up about two fold or more.(See Note 1.)  There is a great article in To You Health called, “ The Sunscreen Dilemma”,  by Jacob Schor, ND. For further reading you may also consider this as well hypothesis about melanoma from 1993: http://www.ncbi.nlm.nih.gov/pubmed/8287144 .  The increase of many other chronic diseases has been documented during the same period.  The vector of vitamin D3 in so many chronic diseases is amazing and I suspect the number one cause of the increase in chronic disease.  The second being exposure to so many industrial chemicals that in some cases are put into our foods and call ‘food’.

So Plough did really well in the sixties selling Coppertone and its Dr Scholl’s line of foot products.  So what if you created a market by keeping people out of the sun and increasing chronic disease – how could you profit from it?   By developing and selling drugs for treating chronic disease.  So Schering  a company that specialized in drugs to treat chronic disease merged with Plough in 1971 to form Schering-Plough, Inc.   In a recent review of SP’s annual report it was interesting to note that 20 percent of their income was from their sunscreen products and 80 percent was from statins, hypertensive, chemotherapy, and other drugs for treating chronic disease.  It was the ‘70’s when the push for really using sunscreen products truly began and it was a great marketing campaign to sell pharmaceuticals for treating chronic disease.  What—?

Now with a pending class action suit that was filed against SP and others in California in 2006 and at least one study coming back to show that sunscreen may actually make the incidence of skin cancer worse, Schering-Plough sells out to Merck.  Now I suspect depending on how the common stock was handled that the liability exposure was significantly reduced by this acquisition.

Ah, lies, damn lies, and the conforming to the institution for protection of the institution truly is evil as described by M. Scott Peck in ‘People of the Lie” when empathy is not taken into consideration.  Dr. John Cannell of the Vitamin D Council simply says that we have ignored the facts over the years.  I say that we have ignored the facts as negligent misadventure with intent to profit from death and disease.

GO INTO THE SUN AND DO NOT WEAR SUNSCREEN.  STAY ONLY LONG ENOUGH UNTIL YOU JUST START TO TURN PINK.  WEAR THE LEAST AMOUNT OF CLOTHES POSSIBLE DURING THE MIDDAY SUN. IN THE WINTER USE TANNING BEDS OR SUPPLEMENT WITH VITAMIN D3.           – Pandemic Survivor

Note 1:  Skin cancer rates from 1975 to 1995 annual percentage rate increase was 5.1 percent.  Given that the natural logarithm of 2 times 100 is about 70.  70/5.1 = 13.7 years to double.  So at 28 years we would have a factor of times 4. http://seer.cancer.gov/statfacts/html/othskin.html   SEER fact sheet on skin cancer.

Genetic, Epigenetic, and Vitamin D3

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Researchers clear your minds as this is the opportunity for new novel designs for preventing and healing disease.

Note 1.

Dr. John Cannell of the Vitamin D Council says that Vitamin D3 targets over 2000 genes or about 10% of the genome.  We have long thought that we are predisposed to get this disease or that disease because our genes were pre-programmed.  We have thought that the genes were responsible and this is correct.  But in the human body it is not only that the genes exist, it is whether it is turned off or on.

Not being hampered by an education in the biological sciences I can freely speculate about how this happens.  We too often are so tied into how a certain thing works.  Our models that we have created in our minds become permanent fixtures. This may or may not be how a process actually presents itself.  Science has had a long history of confirming a certain theory only to find out later that there is more or worse it is not even close to being accurate.  However, the theories that we have developed allow for many wonderful outcomes.

This is the case with genetics.  It is my belief that everybody has a reasonably reliable gene map.  That is; it is capable of given you a healthy life.  Something in our environment has allowed this gene map to be turned off/on.  Genes are almost ‘digital’ in this matter.  Only on occasion do we have a part on gene and part off gene.  Or some cells may be turning on a gene and others may be turning off the same gene or a ‘fuzzy logic’ sort of action.  This happens in tumors where the immature cells continue to grow and their program to stop growth does not act for apoptosis or programmed cellular death.

The genes are present so you cannot really say that we are genetically predisposed.  What has happened is that either because of the stress of the environment or the diet that we consume has had a significant impact on our genes.  Yes there is imprinting from parent to child, but can that be affected by our present environment and our diet.  Evidently this is how the vitamin D3 works.

Here we introduce epigenetics as a way to turn off and on genes.  Epigenetics time line can be seen at this google page where a history of our understanding of this science is displayed.  We see that most of the work in this science did not start to happen until the twenty first century.  We mapped the genome and found that we could not with certainty say that this gene caused a certain happening.  The gene existed, but it was whether it was turned off/on.  This control ‘above genes’ is known as epigenetics.

This idea about how our environments stressed us and our diets affected us in this manner was promoted in a book by Bruce H. Lipton, Phd ( you may find his work here: http://www.brucelipton.com/) called ‘The Biology of Belief’.  Now this was too far out for most doing research in the biological sciences because they had always believed that if the gene existed it would give you a certain result.  It is like saying that because you have a light bulb with power attached that you will have light without consideration for whether the switch is turned off/on.

Some years ago Dr. Randy Jirtle at Duke University starting doing work with twins to try to make some sense of biology versus nurture.  His discovery was that it is both.  You can find out more about his work at this PBS Nova Science Now website.  There is a short video describing his findings.  Be sure to watch one of his researcher’s ‘Tale of Two Mice’ in the middle of the page.  In brief what they found was that by feeding the mother certain nutrients that they could make the offspring either thin with a brown coat or fat with a gray coat.  I am like the fat mouse with the gray coat.

This lead to the discovery that bisphenyl-a or BPA could give an undesirable effect.  Many recent news articles have been published about how BPA would affect your baby.  Here is a recent article form the Chicago Sun-Times. If the bottles that you were using had this form of plasticizers then you could expect a not so good effect on you child.  I believe that by now all of the baby bottle manufacturers have voluntarily removed BPA as they were most likely concerned over the liability.

If you would like to read more about Dr. Randy Jirtle’s work you can find it at his geneimprint website. Also here is his Duke web page for the researchers. It has a brief description of the current work on carcinogenesis.

It seems that methylation or the binding on the surface of genes by methyl groups (free radicals) keeps the genes from expressing themselves for your health.  There are some great images from ‘A Tale of Two Mice’ above that clearly show how this works.  Now some genes we want turned on and some we want off.  In the case of the mice it was a ‘fat gene’ that was staying on constantly.  By feeding the mice methyl donors, the gene was forced off. This seems like a very precarious balance that we need to negotiate.  After all in the press we read about how ‘free radicals’ are really bad for us but in some cases it appears that they are a necessity.  I would suspect that when you are eating the right things this ‘fat gene’ gets turned off and tells the body to not eat any more food.  I also suspect that the mounds of junk food that we eat do not have the right kind of methyl donors.

Now Dr. Cedric Garland and Dr. John Cannell (Newsletter on Vitamin A) have both expressed concern over too much Vitamin A as they believe that it somehow ‘blinds’ the receptors for vitamin D or VDR’s. Dr. Cannell thinks that taking any preformed vitamin A may give you a problem.  He thinks that people should only get their vitamin A from carotene and let the body make whatever retinol and retinoic acid that it needs.  I do not believe this is the case.  This gives me a real disconnect when you read articles about how too much beta-carotene is not good if you have prostate cancer and lung cancer.  This most likely is because vitamin A and vitamin D are antagonist and they deplete each other as the body is using them for health.  Without enough vitamin D to balance the A the cancer gets worse.

During the healing of my vertebral disc, I found that by taking vitamin A from fish liver oil that the cartilage healed quicker.  I had my major increase in height where I actually grew an inch and one half (a sign of healing vertebral disc) in three months when I started taking this form of vitamin A.

I had found from the Oregon State Micro Nutrient center; and from this article from Japan;  that vitamin A and vitamin D worked together for cellular differentiation of chrondrocytes or the cells that form cartilage.  There were many more articles but these two will get you started.

It seems that dimers are formed from the large family of retinol receptors or RXR and vitamin D receptors or VDR.  Also I found that retinoic acid receptors, RAR, and thyroid receptors, TR, work in synergy for cellular differentiation as well. I also started a seaweed supplement for iodine for a healthier thyroid.  If you chose to read more then you may find a paper on this understanding at the Journal of Biological Science, Nuclear Import of the retinoid X receptor, the vitamin D receptor, and their mutual hetrodimer.

So where does this lead us.  Given the body of work by the many scientists on how vitamin D prevents so many different diseases, I propose that vitamin D3 is the ‘master switch’ of epigenetics from nutrients.  It acts like a shepherd in allowing the body’s various hormones to act for your health.  Genes that need to be on get turned on and genes that need to be off get turned off.

The new body of research and drug development for treating various diseases should be pointed toward the combination of nutrients for healing.  I know that the work will most likely be pointed toward drugs and we will just have to read the research to find out what combination of foods will give us health.  After all, our system of medicine is about treatment, the money that results, and not prevention.  However, now that we know the ‘master switch’ or vitamin D3, we can start down the road to health.

I have not lost the weight even though vitamin D3 has a significant effect on blood sugar and insulin which are some of the controls for appetite.  I am that fat gray mouse.  What are those methyl donors -give me some of that!  Somehow I need to overcome the ingrained statement in our family at dinner; ‘Now I need just a little something sweet.’  I suspect that this saying is gene imprinting from my mother-in-law.  Don’t worry; she does not have a computer.  Our environment and how we perceive ourselves and our needs definitely affect our genes.

Get rid of all the bad carbs, eat more good fats, be sure to get enough protein, eliminate the artificial sweeteners because we do not have a clue, and GO INTO THE SUN. 

– Pandemic Survivor

1. Okay researchers, how are you going to make some sense of the combination of nutrients?  I do not think our present statistical method for evaluation of combination of factors will get the job done.  I know that we have forever been using analysis by the variance.  This type of model requires way too much data to determine what is happening with certainty and really does not point to which factor and their interactions that gives you the result.  In manufacturing, I learned a method of analysis of the means which allows you to use small data sets of 3 to 10.  It will plainly show which factor causes what result and more importantly the interaction of the factors and results.  This interaction is what is extremely important in epigenetics. ANOM has been shown by many scholarly papers to be as precise as AOV.  Ellis R. Ott, (ASQ bio) developed ANOM for his work in military and industrial applications which require much accuracy before making a process change.  You can learn the method from his book: ‘Process Quality Control’.  This graphical method will point you to the correct solution without headache.  I am sure that it is available from Amazon as well.

Vitamin D, Disease, and Research

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In 2006, I went to PubMed, the government clearing house for medical publications, and just entered vitamin D in the search engine and limited the search to that year.  There were over 2,100 papers.  I just did this for 2008 and there were over 2,300 papers.  If you limit it to the last ten years it comes up with over 17,000 papers.  The published recent work on vitamin D is voluminous.

The Vitamin D Council has provided a wonderful list of diseases that have been associated with vitamin D deficiency on their research page.  You go there, pick the disease and it sends you to PubMed right to the abstract of the article.  If you do not have a subscription to the particular journal you can purchase the article from the publisher online.

In reading this list, it makes me wonder why there are so many diseases and so much research and yet the medical profession is not treating with vitamin D.  There are so many diseases that are a result of or have a component related to D deficiency, you would think the news organizations would be all over this, but I digress.

If you are a doctor or a researcher and you are trying to just get a feel for the research that is out there then Dr. John Cannell has organized the research by disease.  It is a starting place as there are still many diseases that he has not listed.  For example, I had degenerative disc disease that is really a form of osteoarthritis.  This disease caused severe chronic pain, muscle wasting in my legs, central sleep apnea, memory loss from brain shrinkage with the pain, and other symptoms from oxygen deprivation from the sleep apnea.  If we took sleep apnea we find that it is not in the list because no one has done any research on it and vitamin D even though it has an obesity and stenosis vector which both can be tied directly to vitamin D deficiency.  There is a lot of work that is left to be done and a lot of miss-education of doctors, researchers, and the public in general that needs to be corrected.

Another disease that is not listed is psoriasis and I know that it can be treated with vitamin D according to Dr. Michael Holick of Boston University.  Dr. John Cannell has done a great job and we are grateful for his work, but the tentacles of vitamin D reach far and long in the course of human health and disease.

If you do not find the disease that you have interest with, then just go to PubMed and search on the disease itself and components of vitamin D.  Also I am sure that if you can identify research and that has not been listed then the Vitamin D Council would be interested.  Send that along to them.

Let’s just make a copy of the list without comment to see how long it is:

Vitamin D Council Research Links by Disease

Addison’s Disease
Allergic Hypersensitivity
Alzheimer’s Disease
Ankylosing Spondylitis
Asthma
Autism
Autoimmune Illness
Benign Prostatic Hyperplasia
Bladder Cancer
Brain Cancer
Breast Cancer
Cancer
Celiac Disease
Cerebral Palsy
Chronic Obstructive Pulmonary Disease (COPD)
Chronic Pain
Cognitive Function
Colon and Rectal Cancer
Cystic Fibrosis
Depression and Seasonal Affective Disorder
Diabetes
Endometrial Cancer
Epilepsy
Ethnicity and Vitamin D
Eye Cancer
GastrointestinalFunction
Gaucher’s and Fabry’s Disease
Vitamin D and Genetics
Graves’ Disease
Hashimoto’s Thyroiditis
Heart Disease
HIV and AIDS
Hypertension
Inflammatory Bowel Disease
Influenza
Innate and Adaptive Immunity
Liver Cancer
Liver Function
Lung Cancer
Lymphoid Cancer
Melanoma
Mental Illness
Mineral Metabolism
Multiple Sclerosis
Muscular Weakness and Falls
Obesity
Osteoarthritis
Osteomalacia
Osteopenia
Ovarian Cancer
Pancreatic Cancer
Parathyroid Function
Parkinson’s Disease
Pediatrics
Post menopause
Pregnancy and Lactation
Premenstrual Syndrome
Prostate Cancer
Renal Function
Rickets
Sarcoidosis
Sickle Cell Disease
Skin Cancer
Stroke
Toxicity
Toxin and Radiation Exposure
Tuberculosis
Turner’s Syndrome
Vitamin D Deficiency

Other items of interest for Vitamin D with links to the research:
Best Science
Commentaries and Editorials
Genetics
Requirements
Reviews
Treatment
UV Exposure
Veterinary and Animal Studies
Worst Studies

Vitamin D Council Research Links by Disease

Well, I hope that you find this useful and that you do not think that just because your disease of interest is not in this list that it does not have a vitamin D vector.  This seccosteroid is the most important steroid of the human body – Vitamin D3.

There is a lot of pain and death listed above.  Shine the light on this research!!!  – Pandemic Survivor