Category Archives: Vitamin C

Human Production of Vitamin C

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Human C

I had reported early the finding of Dr. P. R. Raghavan for increased levels of vitamin C in diabetes cases when treated with Metadichol. (Metadichol Induces High Levels of Vitamin C) It appears that the increase was activation of the gene responsible for making the enzyme necessary for the completion of vitamin C production.  This was based on the findings of Dr. Raghavan’s gene studies. This is true in animal studies not yet proved in Humans as the GULO gene is non-functional. Does Metadichol activate the dormant GULO gene in humans despite it being mutated? Studies provided by Skanda Life Sciences shows that Metadichol does activate the gene responsible for the missing enzyme in mouse studies. “Metadichol, Vitamin C, and GULO Gene Expression in Mouse Adipocytes” Link to PDF Metadichol-Vitamin-C-Gulo The loss of production for vitamin C in humans and not in other animals is a mystery.

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Vitamin C is so important to immune health that without it we would soon die of scurvy. Sailors in past centuries developed the disease because of the lack of fresh vegetables and fruits. The British used limes to provide vitamin C and the Germans used sauerkraut (Thus, the associated nicknames). Recently a physician in Norfolk Virginia found that he could treat septic shock (deadly blood infection) with vitamin C, thiamine, and hydrocortisone. The physician has had only one death after treatment of 150 patients. This shows the significance of how important vitamin C is to the immune system, and may explain how Metadichol works so effectively on so many different diseases.

Metadichol boosts the immune system in many other ways. One of the more important ones is how it affects the action of the vitamin D receptors. The vitamin D receptor acts like a conductor of the orchestra for other nuclear receptors. One very important action of the receptors is the making of antimicrobial peptides that are killer cells for all pathogens. Vitamin C supports many of the functions of neutrophils. Neutrophils (white blood cells), another important immune system function, ultimately converts to various types of killer cells that hunt down pathogens.

Vitamin C also has a role in stem cell production as well as collagen folding. This makes Metadichol very significant in wound healing. Treating and preventing infection and acting in wound repair. It is truly amazing how this one substance can act in so many ways. Collagen is useless without folding of the molecule. Because of the folding of collagen, vitamin C is also very important for building strong bones. Thanks for reading­­–Mark Pegram

More Resources:

https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
https://www.nature.com/scitable/topicpage/the-mystery-of-vitamin-c-14167861
Effects of Vitamin C on Neutrophil Function: https://www.ncbi.nlm.nih.gov/pubmed/17235150
Other articles about Metadichol and research papers: https://pandemicsurvivor.com/category/metadichol/  

Metadichol® Induces High Levels of Vitamin C

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Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Post LabelLinus Pauling, a two-time Nobel Prize winner, spent a significant effort in promoting vitamin C in the prevention and treatment of disease.  He was scoffed at by the mainstream medical community. Now, there appears to be better acceptance of using vitamin C to treat disease. It is interesting to note that humans, unlike other mammals, do not make vitamin C. Goats are known to make large amounts of vitamin C each day.  A one hundred fifty-pound goat can make as much as 13,000 mg each day. I typically take one to two grams of vitamin C per day.  If my noise is running, I have found that it will stop in a few hours by taking a gram of vitamin C per hour.   

Typical reference range for plasma vitamin C is 0.2 – 2 mg/dL or 11 – 114 µmol/L.  In the study, Dr. Raghavan found that oral supplementation of 5 mg of Metadichol per day raised the plasma vitamin C to or above high normal.  Speculation has been that Metadichol accomplishes this by reducing the requirement for vitamin C as the body gets healthier, recycles vitamin C, or turns on the gene responsible for producing vitamin C.  In any case, this case study shows the effectiveness of Metadichol in reducing disease.
Metadichol® Induced High Levels of Vitamin C: Case Studies
Raghavan PR* Metadichol-Induced-high VitaminC levels (link to paper)
Abstract
We recently reported that Metadichol® [1] brings about a three to four-fold increase in Vitamin C levels in patients without the use of Vitamin C supplementation. In this study of 6 patients who experienced a 5-12 fold increase in plasma Vitamin C levels higher than 80-100 u mol/L level which is the highest reported to date by oral supplementation at high doses of Vitamin C. Metadichol improved in these patients TSH levels, normalized High Blood pressure, fasting glucose levels, reduced eosinophil count, high triglycerides, body fat reduction and increased bone mass, normalized sodium levels, reducing high insulin levels, increased creatinine output in urine and also reducing of Red Cell Distribution width %. Metadichol thus serves as a surrogate for Vitamin C at doses of 5 mg per day as opposed to mega doses that are currently used.

Other articles on Metadichol

July Papers for Metadichol

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Dr. P. R. Raghavan has written two new papers for Metadichol. This again shows the diversity with which Metadichol acts.  Metadichol acts on hundreds of genes to allow the body to repair.

The first paper is about the only known substance to act for red blood cell distribution width improvement (RDW). It is believed that RDW is a marker for many types of autoimmune diseases.  Here is the summary for the paper.

 Abstract

Red blood cells originate in the bone marrow. Red cell distribution width (RDW) show sizes of circulating erythrocytes (RBC) and has been explored in several large clinical databases to be a robust marker of adverse clinical outcomes in patients. The prognostic value of RDW is seen in other conditions with end-organ dysfunction such as renal failure or. Elevated RDW levels are of significance in diseases such as kidney diseases. The high RDW levels are an indication of increased oxidative stress and closely related to the presence and poor prognosis of the disease. No known therapy exists that can normalize RDW levels. In this paper, we present here case studies using Metadichol®, that leads to normal RDW levels in patients with CKD and PKD.  Here is the link: RDW-paper

The second paper is about allowing vitamin C to be naturally produced in the body.  This is very unusual, but Dr. Raghavan believes that Metadichol activates the gene responsible for producing vitamin D.  This is based on the genes that are activated that were found in his gene studies.  Here is the summary for the paper.

Abstract

Vitamin C, also known as ascorbic acid, is a water-soluble antioxidant. Today we meet our requirements of vitamin C through consumption of fruits and vegetables or by supplementation. Homo sapiens cannot produce vitamin C like many other species that can convert glucose to vitamin C. The gene for enzyme production is dormant in humans. The gene, GULO, that we all carry converts glucose to Vitamin C. in other species but not in humans and primates. The open-label study showed Metadichol® raised levels of vitamin C by 3-fold, endogenously without supplementation of Vitamin C. Possible mechanisms for the increased Vitamin C levels through antioxidant pathways are presented. Metadichol® [1] is a nano-formulation of long chain alcohols derived from sugar cane. In addition to increased Vitamin C levels reduction in Potassium and uric acid, and decreased blood pressure and improvement in quality of life issues were also observed.  Here is the link to the paper: vitamiC-metadichol

Whatever you may think about the action of Metadichol, I believe it to be truly amazing. Here is a link for all Metadichol articles and papers.  –Pandemic Survivor

Understanding Vitamin D with other Nutrients

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When the understanding that cod liver oil would help to prevent and heal rickets was made, there was no understanding as to the mechanisms of action of the components of cod liver oil.  All that was known was that if you used cod liver oil, rickets and some other diseases were prevented and cured.  When modern medical research began to decide mechanisms of action to predict the correct amount of vitamin D in combination with vitamin A, confusion has issued.  There is currently a battle about the correct amounts of vitamin D and vitamin A between the Vitamin D Council and the Weston Price Foundation.   Vitamin D Council on the ratio for vitamin D and A (please note the other articles in the left hand column on Vitamin A and CLO);  Weston Price discussion;  and update

I believe that the confusion arises from trying to extrapolate useful information from a nutritional or medical study considering one or two nutrients that is being evaluated using analysis of the variance -ANOV.  Human biology is much more complicated as the interaction of many nutrients gives us health or disease.  After decades of making the same error, manufacturing has been able to overcome this confusion by using analysis of the means.  ANOM gives not only the outcome of the principle inputs but also the interaction of the various inputs.  Until better methods are adopted by medical/nutritional research, we are just left with the best guess interpretation of the ‘experts.’

So where does that leave us?  I believe it is about what gives you health or disease.  I have been supplementing with the nutrients in which we are deficient for eight years now.  The interaction and the amounts of daily intake of vitamin D, vitamin A, vitamin C, sulfate, iodine, and magnesium are critical.  When I have started to feel bad or had other less than desirable symptoms, I have found that I have to change the balance of one of these deficiencies.

After much trial and error this is where I am now in units per pound of body weight per day:

Vitamin D3    40 IU
Vitamin A from fish liver Oil             20 IU
Vitamin C       20mg
Sulfate             40mg
Magnesium      4.5 mg
Iodine                 0.05mg  (example 150 lb weight –  7.5mg)

This of course says nothing of the other nutrients from diet and supplementation that are essential to health.  However, the ones listed above are typically difficult if not impossible to get from the American diet.

These amounts and the sources that you derive the nutrients from may be different for you as our bodies do not all process a given nutrient the same way.  This is due to the fact that we may be deficient or have an over abundance of other nutrients in our bodies to say nothing of our state of health.  Let’s examine an example and you can see what I mean.

Suppose you have low energy and feel cranky.  Knowing that magnesium is responsible for the action of over 300 enzymes you may decide that you need to increase magnesium.  However, there are several other things that may be the problem even if you are getting enough of the above nutrients.  It may be that you are not absorbing enough vitamin B12 because of your age.  Or, it could be that you are not getting enough of the correct types of fats and proteins.  Or, it may simply be that you are eating too much sugar and you blood sugar spikes are the issue, etc.

Eating a great diet of fruits, vegetables, grains, nuts, and meats while supplementing with the nutrients in which you are deficient will give you optimum health.  It is only through your record keeping of how you feel, trial and error of amounts, and types of foods that are consumed can you reach this desire.  There is no magic formula.   There is magic for health when the balance of nutrients is correct     -Pandemic Survivor