Category Archives: diabetes

Metadichol and Glucose Transport

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Once again Dr. P. R. Raghavan has demonstrated how Metadichol works to improve health. In a recent paper, published in the Journal of Stem Cell Research & Therapy, Metadichol is shown to affect the glucose transporter 4 (Glut4 – found primarily on muscle cells) and associated receptor substrates. This explains the control of glucose in patients treated with Metadichol in many case studies.  “Umbilical Cord Treatment with Metadichol, IRS and Glut4 Expressions and Implications for Diabetes” Link to Paper as PDF: IRS-GLUT4-PAPER

It is important to understand that this is a new paradigm for treatment of disease. Typically, in medical treatment research, it has been “one drug–one target.” In the above paper, it is shown how a new understanding of treatment is obtain with “one drug–multiple targets.”  When gene expression as well as nuclear receptors are brought into proper communication, amazing things happen.

Glucose transporters have been shown to increase the transfer of sugars through cell membranes in several ways. Of course, insulation regulation has always been the obvious control of sugar uptake by cells. It is also well known that exercise significantly increases the action of Glut4 which is the transporter for muscle cells. In addition, thyroid hormones play an important role in glucose transporters (which means that iodine and selenium are important). Now for the first time, the regulation of glucose transporters is shown to be affected by a food substance.

Metadichol is a nano-emulsion of waxy aliphatic alcohols, policosanols. The difference of Metadichol and other policosanol supplements is the small particle formulation. Policosanols can be found in many plants. Modern processing of foods has significantly changed the way our bodies take up policosanols. The most concentrated areas of policosanol are on the surface of leaves and husk of seeds and grains.

This is exciting news for diabetics who may be able to control their blood sugar with a substance that does not have side effects, Metadichol. 

 

References:

Glucose Transporters–Wikipedia

Signaling Mechanisms that Regulate Glucose Transport

Glut4–Wikipedia

Glucose Transport Pathway

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Metadichol—Use for Metabolic Disease

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Sym DiabeticMetadichol was reported last year as being effective for Type 1 and Type 2 diabetes in case studies.  Two issues for diabetes are insulin resistance and obesity.  A target that is now being researched for metabolic disease is GPR-120.  In research by others, GPR-120 agonist has been found effective in anti-inflammatory, insulin sensitization, and anti-obesity effects.  Metadichol has been found as a GPR-120 agonist.

The paper, Metadichol® A Novel Nano Lipid; GPR-120 Agonist, reaches the conclusion that: “Metadichol has the potential to serve in mitigating diabetes with a broad spectrum of activity and with a safety that with [of]no toxicity at doses of up to 5000 mg/kg [20-22]. Metadichol is a far [more] effective substitute to prescription drugs, which have been largely ineffective in diabetes and have many side effects that add to health care costs.”

Here is a link for you to download the paper: GPR-120 Agonist Metadichol

Mark Pegram

Citation: Raghavan P.R. Metadichol® A Novel Nano Lipid; GPR 120 Agonist. Int J Diabetes Complications. 2017; 1-3.

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.   Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6  https://www.ncbi.nlm.nih.gov/pubmed/24997608

Diabetes Solution – Metadichol

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Sym DiabeticA novel approach to solving the issues of diabetes shows Metadichol to be a winner.  Dr. PR Raghavan had originally published a paper for a case study for type 1 diabetes, Case Report of Type 1 Diabetes. Journal of the Science of Healing Outcomes: 2010; Vol 2(8/9):24. After five years and ending treatment the patient is still producing insulin.

  He is now to publish in the Science of Healing Outcomes in July a case report for type 2 diabetes.  Metadichol and Type 2 Diabetes Case Report (Metadichol Type2 Diabetes). From the introduction: “Globally, it is estimated that 366 million people had diabetes in 2011 (5). The number of people with type 2 diabetes is rapidly increasing in every country and in some low to middle income countries, up to 80% of people have diabetes.”  This disease ravishes the body and ultimately causes death from organ failure.  It is a disease of poor eating habits: “Type 2 diabetes is a metabolic disease that can be prevented through lifestyle modification, diet control, and control of overweight and obesity. Education of the populace is still the key to control this emerging epidemic.”

Figure 8The results from the case study are amazing as the person was on no other meds, having chosen to use only Metadichol.  The figure 8 graph from the study shows a clear reduction in glucose as tested during various times throughout the day. The patient’s HbA1C was reduced from 9.8 at baseline to 6.2 at day 84.

Is Metadichol going to work for diabetics?  This is yet to be determined. This study of one person may have had significant changes in glucose because the person changed their eating and exercise habits.  Eating habits are not reported and do have a significant impact on type 2 diabetes.  However, the case study that was first reported for type 1 warrants a significant clinical trial to determine the efficacy for Metadichol for treating diabetes. Since policosanol (the primary component of Metadichol) is a food substance, this trial could be safely carried out on large populations with people that are willing to log their eating habits during the trial.

As reported in other articles on Metadichol, Dr. Raghavan believes that the effectiveness is from how nano-policosanol acts on the vitamin D receptor (VDR).  It appears to act as both an agonist and an inverse agonist which is very unusual.  In addition, Metadichol acts on many genes and other nuclear receptors as reported by Dr. Raghavan.  Will the medical community embrace a food substance for treating disease—all, yet to be determined?  – Pandemic Survivor

New Nutraceutical, Metadichol® – Breathtaking Results!

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“One good nutraceutical can wipe out the drugs.” Dr. Stephen De Felice

As a regular reader, you have seen several post of the new form of policosanol as a small droplet emulsion, brand name, Metadichol®. (Historic Breakthrough in Health – A Natural Alternative to Vitamin D) This natural substance appears to present a new model for how healing should occur in the body. As a natural substance formed on sun splashed portions of plants, it appears to act in the body very similar to vitamin D. This is a claim in the one of the many patents covering Metadichol®. As you know, you cannot patent a natural substance; however, the novelty is the small droplet that easily absorbs into the body and blood stream where it can become active in cells.

Some of the claims in the patent for healing are as follows: malaria, acne, eczema, ganglion, lipoma, MRSA, wound healing, fungal infections, psoriasis, hair growth, wrinkles, kidney disease, regulates glucose, insulin resistance, Diabetes type 2, Cholesterol, improved lipid profiles, hypertension, kidney disease, heart disease, reduced protein oxidation or oxidative stress, TNF a – significant immune system function, and increases serum vitamin C.

This product has only been on the market since the last part of 2014 in Southeast Asia. The reports coming from that area are amazing in the variety and healing of many diseases. The amazing thing has been no side effects. Of course, since it can be found of most foods, there should be no side effects. This appears to fall into the first rule of medicine, do no harm. When I was first approach by the discoverer, I thought – yeah, yeah another nut found a way to make money. Now after two months, I am truly amazed at the results from my own experience.

My own experience was first the amazement that the pain from my wife’s shingles went away in just a couple of days. It is interesting to note that her primary care physician had identified the rash as shingles along the C3-C4 dermatome. My wife has experienced shingles before that went on for over six months. After four weeks, there was still some redness and my wife went to see a dermatologist who is a friend of the family (I may have instigated this visit because of my prior communication with the dermatologist about Metadichol®). The dermatologist said that it was not shingles, primarily because it had gone away so fast and the apparent appearance of the remaining rash. She described it as a rash of unknown origin. I suspect this type of healing is unfamiliar to the dermatologist.

As for myself, I had a hemorrhoid that shrank overnight after an application of Metadichol®. Also, I treated a wound that I had received from cutting wood. It healed very quickly without a scab formation which I found extremely interesting. After about four weeks of using Metadichol®, there were red formations on my arm and leg. They appeared to be like large pimples or a formation of a colony of bacteria that looked similar to the appearance of MRSA that I had five years ago. After a few days of treatment with the Metadichol®, the redness disappeared. I now wonder if these areas were not colonies of pathogens trying to escape from the action of the Metadichol®. Also, the lipomas are shrinking on our 13 year old dog. We simply spray a couple of sprays on her food every day. We tried to treat a lick granuloma on the dog’s leg. This appeared to work well for a couple of weeks, but the dog started to lick again and the inflammation still exists. We have not tried to increase the dose for the dog. Also intermittent treatment may be an issue as well.

The mechanisms for how the substance works is not truly understood. Dr. Raghavan, the discoverer believes that there is some form of communication that appears to give intelligence to the action of Metadichol®. He has tried the formulation with synthetic components of policosanol and it does not work. He believes that it may be plant and microbial DNA that gets extracted along with the policosanol. It would be interesting if the Metadichol® is also renewing the health of our microbiome and homeostasis is reached in the body through this symbiotic relationship. The consideration of how it may possibly work because of DNA that comes over is daunting when considering the amounts of GMO foods that we are now consuming.

There are to be publications about Metadichol® that will appear over the next several months. This will include information on how our genome reacts and treatment of some very serious diseases. It will be interesting the response of the medical and research communities. – Pandemic Survivor

“Human subtlety will never devise an invention more beautiful, more simple, or more direct than does Nature— because in her inventions, nothing is lacking— and nothing is superfluous.” Leonardo da Vinci

Breast Cancer Survivor Takes on the Issues

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Carole Baggerly had her own experience with breast cancer. She then started to research the reason why. Her discovery; scientists have expressed the understanding that breast cancer is a deficiency disease. That is over her life time, her intake of vitamin D was not adequate. She was so upset and concerned about the issues that she started GrassrootsHealth. This is a consortium of more than forty scientists and doctors that are experts in vitamin D and nutrition. She discovered that it was not only breast cancer, but a host of chronic illness related to deficiencies. Take the time and watch her explain the issues in the first thirty minutes of this video presentation.  Carole Baggerly and Dr. Heaney, September, 2012  Presentation to Direct-MS Canada.

If you are concerned about the health of your children, yourself, your parents, the next hour is Dr. Heaney who has contributed significantly to the understanding of vitamin D. He talks about the longevity issues and decline with chronic disease because of nutritional deficiencies. There are many diseases that have now been linked to deficiencies that number into the hundreds. This is particularly pointed to vitamin D deficiency.

This discussion is fairly non-technical and is understandable by the average person. Dr. Heaney expresses the understanding that “things go better with vitamin D”. That is that vitamin D deficiency may not be the cause of a disease like TB, but not having enough vitamin D will prevent your body from properly healing. However, this understanding falls into the logic of the chicken versus the egg. In other words, if you had enough vitamin D would you have gotten TB in the first place? Dr. Heaney discusses everything from diabetes, heart disease, MS, pregnancy, and cancer to infectious diseases like TB. I give the video presentation six stars out of a five star rating system for understanding of chronic disease and the effect of vitamin D.  Presentation to Direct-MS Canada.

Your take away from this, is you, your friends, and your family should not suffer from vitamin D deficiency.   Standards within the medical industry have long been 20 ng/ml to 100 ng/ml.   There have not been any cases of toxicity below 200 ng/ml or 500 nmol/l.  There does not appear to be any downside at this level of vitamin D.  Some laboratories have decreased the upper number, 100 ng/ml, to whatever they are measuring the population. Best health for you can be reached with a vitamin D serum level, 25(OH)D between 40 ng/ml to 80 ng/ml; note this is still within the normal range as defined by medicine. It is not how much you take; it is where you maintain your serum level. Everyone responds differently to their intake from all sources of vitamin D. The only way to know is to test.  Dr. Heaney says to maintain a level above 40ng/ml will require an intake from all sources of 5000 IU or more of vitamin D3 per day.

Please note this presentation is in Canada. The measurements used are in nanamoles per liter or nmol/l. To convert ng/ml to nmol/l multiply ng/ml by 2.5. So the normal range of 20 to 100 ng/ml is 50 to 250 nmol/l. Get your serum level tested to give your body a chance to thrive. If you choose to do it through GrassrootsHealth, you become part of the study that will help to advance health in the population. – Pandemic Survivor

Test by GrassrootsHealth: banner_ad_long5company postingVideo of how to do the test:  bscvideothumbnailv3web

Grassroots Health Webinars on Vitamin D

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The scientist, researchers, and doctors at Grassroots Health have been presenting webinars on vitamin D and various topics.  This is a wealth of information about how a given disease works with vitamin D as well as the interaction of calcium.

I highly encourage you to go to the website and watch and listen to the webinars.  There is a new one every Tuesday at 1PM eastern time.  Also after becoming familiar with the information, I encourage you to ask your doctor to watch, if he is giving you a hard time about supplementing with vitamin D.  It is important that you maintain your 25(OH)D level above 40 ng/ml.

If you don’t watch and listen to any of the others, I highly suggest that you watch – Why Test Vitamin D!?  The question is always – How much should I take?  This gives you and understanding that everyone responds differently to amounts.  At the Grassroots Health home page you can find a table of how to start supplementing before testing.     There is also a downloadable chart as a PDF.

Here is the link to the Video Page http://www.grassrootshealth.net/index.php/videos

  • Diabetes & Vitamin D
  • The Sun & Vitamin D I and II
  • Pregnancy & Vitamin D  I and II
  • Upper Respiratory Infections & Vitamin DI and II
  • Ethic Disparities & Vitamin D
  • Premenopausal Breast Cancer & Vitamin D
  • The Cost of Vitamin D Deficiency: In Dollars & Disease
  • Vitamin D & Calcium, Fractures, & Kidney Stones  What do we know?
  • Why Test Vitamin D!?
  • Prostate Cancer Positive Core Biopsies Reduced with Vitamin D
  • Prostate Cancer Lesions Reduced with Vitamin D
  • Vitamin D Stops Breast Cancer
  • Vitamin D & Gene Expression
  • Vitamin D & Treatment of Autism
  • Pregnancy & Vitamin D Interview
  • Alzheimer’s Prevention & Vitamin
  • Interaction of Vitamin D and Calcium
  • Vitamin D Requirements for Breast Feeding Mothers
  • Vitamin D & Breast Cancer
  • Vitamin D & Cardiovascular Disease
  • Vitamin D & The Immune System
  • Vitamin D & Cystic Fibrosis

Be well and stay healthy – Pandemic Survivor

Happy on the Islets of Langerhans

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The recent news about how beneficial that vitamin D is to the pancreas reminded me of my friend Gus.  Gus is of Greek decent, a retired stone mason, and well, a real character.  Gus loves the Lord.  Now that he is retired, his hobby is making rounds with a doctor that specializes in pulmonary functions.  As the doctor treats the patient medically, Gus prays for their recovery.  Now there is a doctor that understands that life is not just a bunch of chemicals contained in an epidermis.

Gus has learned what it means to be living ‘fat’ in America.  His love of pasta, biscuits, and pancakes has caused him to become slightly overweight and headed directly to type II diabetes.  He was telling me about how he was researching which drug he should take to control his blood sugar.  He was not happy about all of the side effects.

I suggested that he work with his doctor to try to heal his pancreas before diving into the world of drugs.  He decided to maintain his serum 25(OH)D between 60 to 80 ng/ml (this took 15,000 IU of D3 per day in Gus’ case as he is a big guy), take in at least 3 to 4.5 mg per pound of body weight of magnesium as a chelated type each day and lay of the dense carbs.  Staying of the carbs was the real issue.  I at least convinced him to give up the biscuits and pancakes, but the pasta is another story.  Gus loves his pasta.

In a few months Gus was elated as his blood sugar had returned to normal without having to take any drugs.  His doctor was amazed as well as I discovered that Gus’ sugar had been very high.  What can I say, Gus is one happy guy.

There on the Islet of Langerhans, beta cells are dancing happily around in the sunshine and it’s a good day.  – Pandemic Survivor

Higher Vitamin D Intake Drastically Reduces Disease

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A new study of serum levels of vitamin D shows that 4000 to 8000 IU per day are required to keep your serum level in a range that will reduce the incidence of disease. This includes cancer, type 1 diabetes, and multiple sclerosis.  Dr. Cedric Garland says that the incidence of many diseases could be reduced by half.

Here is the news article in Business Week: “Higher Vitamin D Level Could Cut Cancer Risk”

As I have described in many post, the amount of vitamin D required is different for each individual.  The only way to know that you are getting enough is to have your serum 25(OH)D level tested.  Serum levels should be maintained above 40 ng/ml, and for best results the level should be maintained between 60 to 80 ng/ml year round.  You should only supplement with Vitamin D3.

For a better understanding of the science, here is the journal article that was published in Anticancer Research, International Journal of Cancer Research and Treatment, made available in its entirety by Grass Roots Health.

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention

CEDRIC F. GARLAND, CHRISTINE B. FRENCH, , LEO L. BAGGERLY, and ROBERT P. HEANEY (here is the url in case you cannot go there from the above link  http://www.grassrootshealth.net/garland02-11)

“This paper provides a long awaited insight into a dose-response relationship between orally administered vitamin D3 and the resulting levels of serum 25(OH)D in over 3600 citizens. The results will allow new definition of high vitamin D dose safety and reduce concerns about toxicity. This is a landmark contribution in the vitamin D nutrition field!”

– Pandemic Survivor

Improving Insulin Sensitivity

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I read an article in the Wilmington Star News online that says that vitamin D is more effective than one of the major meds for controlling blood sugar.  I am surprised that a pharmacist was willing to actually state the truth.  I say congratulations for a job well done.  Before we get into that let me tell you about a friend that I know that struggled with type two diabetes.

I had told him about the research on vitamin D and diabetes and he was excited to try and keep his serum level up as a means to achieve better health.  After he started to supplement with vitamin D he said that he did not ‘sense’ the extreme up and downs in his blood sugar.  He also said that this helped him to better control his appetite and he lost thirty pounds over a six month period.  He got off all the meds for type 2 diabetes.  Now his fasting blood sugar is normal.  I am not saying that taking the vitamin D healed his type 2 diabetes.  I am sure that the loss of the weight had a significant impact.  In any case we have another survivor of a significant chronic disease and better he did it without staying on pharmaceuticals.

Okay so here is the story for the Star News online where this pharmacist says that vitamin D is five times better than one of the meds known as the ‘gold standard’ for treating insulin sensitivity.  I find this most amazing!  “A ‘D’ once a day will keep the doctor away”

If your doctor does not believe that vitamin D will have this kind of effect then I would suggest that you have him read the research that the pharmacist refers to.  Also a really good paper is one by Dr. Heaney of Creighton University where he describes blood sugar being blunted and insulin response improves once your blood serum 25(OH)D is above 32 ng/ml (80 nmol/l).  The name of the paper is ‘The Vitamin D requirement in health and disease’ as published in J Steroid Biochem Mol. Bio.  Oct. 2005.

Taking a lot of vitamin D if you have type 2 diabetes is not going to do that much good if you choose to keep eating sugary and starchy foods.  Even the best attempt at good health cannot overcome emotional eating.  (you know I am overweight and love to eat lots of cheeseburgers and my lipids and blood sugar are excellent and they were not before vitamin D – I should ‘practice what I preach’ ) You may ( I am beginning this techniques myself) want to try the new emotional control techniques using motion that are being used like EFT (emotional freedom technique ).

Eat Healthy and go into the sun!                   – Pandemic Survivor

Heart Disease and Diabetes

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As you may already know, the insulin surges that occur when you are diabetic cause a significant amount of plaque to build up in the arteries.  It seems that insulin surges for whatever reason are the cause of this unfortunate course of the disease.  There is hope however that this does not have to be the course of the disease.

You can read the paper, “Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol” by Heaney et. Al with an explanation of how blood sugar and insulin is blunted once your serum 25(OH)D is above 32 ng/ml.  It is an open source paper and I would suggest that you read the full paper if you are diabetic or at least have your doctor read it. From PubMed

Also ‘The Vitamin D requirement in health and disease’ by Dr. Heaney.

Dr. Joe Prendergast of California has a long time practice of endocrinology.  He has treated many diabetics and has had great success in reducing the amount of heart disease in his practice.  Dr. Prendergast discovered in the early nineties that he had a significant amount of heart disease.  His father had died at an early age of this disease.  He decided that he was going to do all that he could not to follow the same course.

He contacted Dr. Victor Zhu who is was head of research at that time at Stanford University to see what he was doing about heart disease.  Dr. Zhu set him up with one of his research fellows that was testing mice with arterial plaque.  Dr. Prendergast decided that he was going to try the same course of treatment that had proved to clear the arteries of the mice.  After a number of years he was imaged again for another purpose and it happened to be the same radiologist.  The radiologist discovered that Dr. Prendergast arteries were clear.  They checked to be sure that the patient file had not been substituted that indeed it was Dr. Prendergast that showed no arterial blockage.

Dr. Prendergast who was at one time head of the board of endocrinology for California decided that he was going to treat the diabetics in his practice.  He has treated over 4000 patients.  The heart disease had reduced to such a low rate in the small city between San Jose and San Francisco that the three man cardiologist practice closed and move to another town.

It seems that he treated his patients with a combination of vitamin D3 and l-arginine.  As you may know there was a Nobel Prize for Physiology or Medicine 1998 awarded for the understanding of the communication pathways for nitric oxide, NO, and how through its signaling pathways it affects the function of the arterial wall cells.  This is what happens when heart patients take nitroglycerin.  However the NO is released in a lower amount when using l-arginine.

It would seem that with such success that this practice would have been adopted by all the doctors treating diabetes.  The vitamin D3 does it thing with the genetics, insulin control, blood sugar control, and the all the other good benefits.  Dr. Prendergast has even written a book about his success in using nutrition with his patients, “The Uncommon Doctor.”

But you know, you do not have to take my word for it.  The owner of Apple Health, David Stouder, was so fascinated by the number of people that were coming to his store to buy vitamin D and the success that they were having in the course of their disease that he decided to interview Dr. Prendergast.  You can go hear the interview at the website set up specifically for that purpose.  www.nutriphobia.com (writers note October 17, 2009 – Unfortunenately this interview has been taken down and I was unable to find it on the new website.  Here is his video comment at youtube )  The first six audios are simply about overcoming the fear of vitamin D and the button ‘click to hear Dr. Joe Prendergast’ is the audio interview with Dr. Prendergast and the above story.  I know that if I were diabetic, I would have my doctor get in contact with Dr. Prendergast for a consult at his practice Endocrine Metabolic.

If you have heart disease or diabetes I would certainly hope that you would spend some time in reviewing this understanding and get your doctor involved.  It is not only your life but it is the life of each patient that your doctor chooses to treat.

In the main time – GO INTO THE SUN!  – Pandemic Survivor