Hypertension – Reduced with A Food – Metadichol

Posted on May 31, 2017 by Mark Pegram

Our diets over the last fifty years have been shifted away from fat and toward carbohydrates with the belief that higher amounts of fat were causing cardiovascular disease (CVD). As this move toward higher density carbs occurred, blood pressure also increased along with the issues of higher incidence of CVD and stroke. In the following study, a food substance, that is typically tossed in the processing of sugar cane, was found to reduce blood pressure and c-reactive protein (CRP) and increased circulating vitamin C. The paper describes the action of nano-policosanol as acting along vitamin D pathways.

Here is my blood pressure as I write this at 4 AM–not bad. Hypertension w

Dr. P.R. Raghavan has given us Metadichol, a nano-policosanol, to reduce blood pressure. Policosanol, as long chain fatty acids, is found in high concentration on sugar cane and the husk of seeds. Here is the paper that was just published for a sixty-week open label study. The remarkable things are that blood pressure is reduced in only three weeks, the production of vitamin C in humans, and reduced CRP, an indication of reduced inflammation.

Systolic and Diastolic BP Control in Metabolic Syndrome Patients with Metadichol® a Novel Nano Emulsion Lipid – Journal of Cardiology and Cardiovascular Therapy Case Report Volume 5 Issue 2 – May 2017 DOI: 10.19080/JOCCT.2017.05.555660 Metadichol-Hypertension

To combat high-blood pressure the normal course is to:

Eat a healthy diet
Regular exercise
No nicotine use as it shrinks arteries
Limit alcohol
Maintain a healthy weight

The above is the typical verbiage that you get from your doctor. I wonder just how many times the physicians say that on any given day. It is apparent that a healthy lifestyle is everything. Of course, government and its agencies have failed us in defining a healthy diet. The common American diet was defined to promote the economy. If you don’t believe this then ask yourself this question: Why do we spend almost twice as much on healthcare as we do on food?

Poor eating habits are the cause of many chronic diseases. Hypertension falls in this category. The first time my realization that diet was critical to controlling blood pressure occurred when I was reading “Protein Power” by Drs. Michael and Mary Eades. They warned of blood pressure dropping significantly with the reduction of carbohydrates. This raises the question of our health actions over the last fifty years. Reduce the amount of fat and increase sugar? Sugar has typically not been considered as dangerous, however, I believe it’s the worst policy we could have made. Linus Pauling (interesting that this is the vitamin C guy and Metadichol helps the body produce vitamin C) showed in the 1970s that sugar was more responsible for increased cholesterol than fat through his studies with prisoners.

The real solution to maintain a normal blood pressure is to eliminate sugar and flour from your diet. Grains were not meant to be finely divided for consumption by our physiology. Sugar is not meant to be consumed outside of its normal occurrence in vegetables and fruits. This is what is meant when we are told to consume a healthy diet.

Metadichol will help maintain a lower blood pressure. Metadichol acts in many ways in controlling our biological actions. The beauty of Metadichol is that this food substance has no known side effects. We no longer consume policosanol that is found in the husk of seeds. It appears that our body needs these long chain fatty alcohols. Metadichol is taking the husk into a modern factory and chewing them for us. Remember the words of your mother: Chew your food! Of course, if you don’t have the right part of the food to be chewed, factory chewing by others is okay.

The irony is that nature gave us policosanol on the plants that are high in sugar, and we throw way nature’s protection from sugar. We then concentrate the sugar through modern processes and consume it in great amounts. Results are devastating to our health. We now develop a substance that counteracts the effects of sugar, that nature originally meant us to consumed with the plant. Sugar drives up serum cholesterol more so than fat. The result of a high sugar diet without the protection of policosanol is CVD and stroke. More irony, the original intent of the Dr. Raghavan was to improve the way policosanol reduced cholesterol as shown by the Cubans. Nature is laughing at us.

One of the very interesting findings in this study was the increase in vitamin C. The paper indicates that humans made vitamin C as part of our physiology. At some point, one of the three enzymes that makes vitamin C from sugar was no longer produced. Metadichol appears to turn on the gene responsible for producing this enzyme and higher vitamin C levels happen. This means reduced inflammation, as indicated by a reduction in CRP, and the possibility of a longer lifespan with less disease.

This is really-exciting stuff. The possibility of increased life span with reduced inflammation and disease through a food substance that can easily be supplemented with no side effects–Metadichol.

We took the chewing of grains into the milling operations to help foods be easier to consume. Sugar was concentrated through industrial processes as our body craves this substance. It should also be noted that sugar was concentrated to help in the production of alcohol–another craved substance. Both things, milled grains and concentrated sugar, made food easier to consume and have significant impact on our economy, but they are not healthy. By not being healthy, we again have made a significant impact on our economy with increased healthcare and insurance. And, the government said, “It is good.” –Pandemic Survivor

Inhibition of Deadly Viruses by a Food Substance

Posted on March 22, 2016 by Mark Pegram

New research shows that an effective antiviral can be made from a food substance. Policosanol made into a nanoemulsion has the possibility of becoming a significant tool to inhibit the spread of some very serious viruses that include: Ebola, Dengue Fever, H1N1, and SARS. Published in the April 2016 edition of the Journal of the Science of Healing Outcomes is the paper, “Inhibition of Dengue and Other Enveloped Viruses by Metadichol^®, a Novel Nano Emulsion Lipid,” by P. R. Raghavan, PhD. (dengue-paper – AUTHORS PRE PRINT COPY)

In this paper the author shows case studies of dengue fever recovery of a female 34 and a male 35 in just a few days without any drugs. Also shown in the paper are positive results of in vitro testing for dengue fever as well as many other viruses. It is the hope that Metadichol^® acts toward the other viruses as it has toward dengue fever. Imagine the less fear that would have been developed during the recent outbreak of Ebola. About 40% of the world’s population is exposed to dengue viral infections with 50 to 100 million infections each year and 22,000 deaths.

Even more important to the average person is the hope that Nano-policosanol is an effective antiviral toward the flu. Imagine the impact if we could recover very swiftly from the flu with an antiviral that is very effective without side effects. The very important highlight of policosanol is that it is nontoxic to the human body. We consume policosanol every day in our foods. The Nano-emulsion version is easier to absorb and become effective in our immune response. Unfortunately, the part of the plants where policosanol is concentrated is usually thrown away as waste. Have we lost the avenue toward better immune systems by not chewing the husks from food?

There are over 1,400 pathogens identified to cause disease in humans. There are many more mutating to adjust to an-every changing environment. How many times in the past year have you heard someone say our use of antibiotics is creating new dangerous bacteria or the vaccine is only 40% effective against this year’s flu? This is to say nothing to the damage that antibiotics and vaccines may be doing to our microbiota which represents over 100 trillion cells in the human body or ten times human cells. The use of food with its vitamins, minerals, enzymes, and genetic expressing processes is a natural way of boasting the immune system that has evolved over the ages with our environment. This may be the answer in our ever persistent battle against pathogens. We cannot create enough vaccines or anti-pathogen formulas to handle the constant surge of pathogens.

In conversations with the author, Dr. P. R. Raghavan, it was interesting to learn that the finding for the use of Metadichol^® against viruses arose out of the use as a supplement. “Chinese and Indians have used herbs and foods to treat illnesses for hundreds of years. My experience in years of developing toxic drugs that do not work, forced me to look for a better alternative. Knowing the importance of vitamin D on human health has ultimately led me to the invention of Policosanol Nanoparticles.” Metadichol^® can act along vitamin D pathways and help to restore proper immune health. He continues, “this is not surprising given that policosanol can be considered an open chain form of vitamin D. Policosanol’s main ingredient is Octacosanol which has 28 carbon atoms and vitamin D3 also has 27 Carbon atoms and both are long chain alcohols.”

Dried Potato Skins

Metadichol has been shown to be effective for many biomarkers (US patents 8,722,093 and 9,006,292) in the nanoemulsion form, and for viruses, bacteria, fungi, and parasites as well. Dr. Raghavan states that he has some very interesting in vitro results for all of these pathogens. He also states that it is very effective in wound healing. “This is not surprising given the fact that dried potato skin was used for skin healing in India. It turns out that potato skin is a good source of the ingredients of Metadichol. In addition, Metadichol also works against Malaria, a parasite, and bacteria like MRSA (see US patent 9,006,292). Recently completed work also has shown that Metadichol inhibits in vitro T-Brucei, a parasite that causes sleeping sickness, T-Cruzi that causes Chagas disease, and Leishmania, a parasite carried by sand flies that leads to Leishmaniosis with symptoms of ulcers of the skin, mouth, nose, etc. All these parasites affect many developed countries in the tropics. Metadichol^® is the only one known in vitro to be active against bacteria, parasites and viruses. This allows researchers for the first time a simple solution that is ready to be tested and deployed world wide to prevent these viruses, bacteria and parasites that affect a large swath of humanity.”

You will have to forgive me, but this reminds me of the explorer movies of the jungle and suddenly there is an illness or injury. The medicine man chews up some leaves and spits it into a poultice. The person with the illness is healed in just a day or so. Great stuff for the movies, but there must have been some basis for the fiction. Maybe we have arrived at a time when nutraceuticals are more effective that drugs.

“One good nutraceutical can wipe out the drugs.” Dr. Stephen De Felice

Metadichol in Southeast Asia

Posted on August 18, 2015 by Mark Pegram

A video of people using Metadichol as brand name Polilex has been posted to you tube by Polilex. This is a very remarkable video. Typically what you see in videos is young people talking about how wonderful things are. In this video, it is mostly old people that are suffering from an array of chronic diseases.

It is amazing to think that something as simple as an emulsion of the waxy substance found on most plants leaves can have such effects. As we move forward in our understanding of nutrients from food, I believe there will be amazing results. How modern foods are processed is of extreme importance to our health.

The video is high quality but the English subtitles are sometimes hard to read.

Historic Breakthrough in Health – Nano Policosanol

Posted on December 22, 2014 by Mark Pegram

“In questions of science, the authority of a thousand is not worth the humble reasoning of a single individual.” – Galileo Galilei

Nature will typically provide at least two pathways or redundancy for anything that is critical to the survival of life. Consider that we have two arms, two kidneys, two eyes, two lungs, etc. If you want to get more technical consider there are two substances to allow homocysteine to go to methionine [trimethylglycine (TMG or Betaine) or the combination of folate with vitamin B12] for the methylation cycle for the expression of genes. The discovery is a substance that works along some of the pathways of vitamin D and enhances the action of nutrients and more.

The remarkable thing about the action of this form of policosanol, as described in the patent, is that it does not drive up serum calcium. This has always been the issue with simply giving the hormone form of vitamin D to patients. Imagine anything that can work on physiological systems of the body without side effects. This natural substance has been consumed forever. Could this be the gift for an extremely healthy life? Like vitamin D in animals, it is also produced by the sun on plants and in many of our foods. The issue has been the ability of the body to absorb it so that it can get to where it needs to be active. The new discovery is the effectiveness of a small droplet sized emulsion of policosanol. Policosanol is found as a waxy aliphatic alcohol on the leaves of sugar cane and in the husk of many grains and in other plants as well. This may be reason that diets like the unprocessed paleo diet are so effective.

In conversations with Dr. P.R. Raghavan, he describes the finding as nature’s way of providing a pathway to health for animals who cannot obtain their vitamin D from the sun. He states that his discovery came from observing rats. The first thing that rats do is to eat grass when experiencing long periods without any exposure to sun. Grass makes the waxy alcohol on its leaves. “Rice-field Rats primarily reside in cultivated areas such as rice paddies and grasslands. It [where they reside] is largely dependent on human rice fields and plantations. Rice field rats shelter in burrows in soil, under rocks, and in logs”. It now makes me wonder when I see a dog eat grass if they are trying to achieve health from policosanol. Animals will do whatever is necessary for survival. Dr. Raghavan has been vigorous in making this understanding.

Consider the elephant with its hard dermal layer. How does it get its vitamin D? Or is its health from eating the policosanol in all the plants that it consumes. “Asian elephants eat a wide variety of plants including grasses, shrubs, bamboo etc. While more than 100 different species may be eaten, only about 10 to 25 foods are likely to make up more than 8% of the diet. The percentage of grasses versus browse eaten varies seasonally; the nutrient value of grass is greatest early in the wet season, while that of leafy browse is higher in the dry season. Elephants do show choice in feeding: foods eaten do not necessarily match foods available. Crops such as bananas, sugar cane and paddy (rice) are favoured.” The sugar cane and paddy rice are very high in policosanol. The serum concentration of 25(OH)D for elephants is low compared to what is considered healthy for animals at an average of 16 ng/ml.

From Dr. Raghavan’s Into to Metadichol: “In the late 1880’s Dutch physician, Christiaan Eijkman was sent to the East Indies(now Indonesia to investigate why beriberi was so widespread in the region. Eijkman observed that hens in his Jakarta laboratory suffered symptons of nerve disease (polyneuritis) that were strikingly similar to those for beriberi – including muscle weakness, nerve degeneration, and paralysis. He then began a series of experiments to try to find a culprit organism, which he assumed was the cause.

He showed that the hens contracted the beriberi like polyneuritis soon after their feed was changed to polished rice – that is, rice whose outer husk had been removed. He also proved that by adding rice bran (the parts removed in polishing) to the hens’ food, the disease could be cured. The outer Husk contains Metadichol (policosanol).” We should clarify here that beriberi is commonly thought to be caused by vitamin B1 (Thiamine) deficiency, but Dr. Raghavan believes that the lack of policosanol was also a cause.

Emulsions are liquid colloids of droplets that are typically less than one micron in size. If you think about homogenized milk, it has fat droplets that range from 300nm to 500nm (0.3 microns to 0.5 microns). There are many small sized droplet emulsions that we normally use. Think about sugar in water, soap in water, or a supplement like vitamin E, vitamin A, vitamin D, vitamin K, etc. in water. The droplet size of the patented emulsion of policosanol, Metadichol®, is about 50nm in size. This allows for easy absorption through the gut wall or through dermal layers if used topically.

Think about the many pathways that are described by Anthony W. Norman for health in his paper:
The History of the Discovery of Vitamin D and Its Daughter Steroid Hormone
Norman A.W. Ann Nutr Metab 2012;61:199–206 (DOI:10.1159/000343104)
It is truly astonishing the possibilities for health through vitamin D pathways of the vitamin D receptor. Consider this diagram derived from this paper for immune response:

Let’s take mast cells as an example in an autoimmune response. The mast cells become over active causing significant inflammation. The Metadichol®, name given in the patent, binds to the mast cell VDR and calms it down. As a result, the inflammation that is being caused disappears. Dr. Raghavan says, “Based on our invitro and invivo data Metadichol ® behaves as an agonist for one receptor and an antagonist or neutral antagonist or inverse agonist for another receptor.” The many cells that are involved in an immune reaction and other physiologies with the VDR makes the possibilities for health unlimited.

Dr. Raghavan likes to describe the VDR super family of nuclear receptors and the action of Metadichol® as follows: “A simplified way of looking at it is that the Vitamin D receptor (VDR) present in chromosome 12 in each and every cell is the conductor of an orchestra and he/she, is not relaying to the orchestra the proper cues. This will impact the performance of other members of the orchestra. Metadichol by acting on VDR restores the conductor to peak performance and ensures that both the conductor and the orchestra will perform at their peak potential (read; disease free).”

We have been scared from the sun for the last fifty years. It is time to take advantage of the nature’s gift from the sun, vitamin D in animals and policosanol in plants. This is truly a wonderful and historic discovery in nutritional health. I believe that it is a discovery worthy of the Nobel Prize! – Pandemic Survivor

Knowledge advances not by repeating known facts, but by refuting false dogmas. – Isaac Newton

Brief Bio: Dr P. R. Raghavan CEO of Nanorx Inc. has a Ph.D. in Organic Chemistry from Oregon State University, USA (1979) and a M.S in Chemistry (1972) from I.I.T Mumbai, India. . He has worked on drug discovery for over 25 years at Columbia University, Max-Planck Institute, Germany, Ciba-Geigy (now Novartis) and Boehringer-Ingelheim Pharmaceuticals. His fields of specialization are CNS, Inflammation, AIDS and ACE inhibitors. His experience in drug research includes Chiral synthesis, process, scale up and clinical research. He has been working for the last 12 years in the area of nutraceuticals and developing environmentally cost effective solutions for Bio-Diesel production.

Dr. Raghavan’s Business Philosophy: “Value for Money and Value for Many”

The Miracle of the Sun

Posted on December 5, 2014 by Mark Pegram

You are a child again and it is the night before that long awaited event. It’s the evening before the little league play off game. You dream of that power shot you plan to hit over the right field fence. Perhaps it is the evening before your birthday or Christmas eve. You know that the doll you have been longing for is wrapped and waiting. In bed, you toss and turn in excitement and anticipation. You know what is about to happen is going to be so joyful and loving to you and everyone you know. I did not think this type of excitement can happen to an old man. It has happened to me in the last several weeks.

It is interesting to think of the things that are required for life. A life with abundant good health that is happy and joyful. What are those things that you need ? Without air, you would die in a few minutes. Without water, you would die in a few days. Without food maybe you could make it for a couple of weeks. How long would you make it without the sun? Without the sun you would have no food and possibly not enough heat to survive. And could you survive without love? Think of the trial in the 1930’s when they tried to feed babies without touching them. The trial was ended because the babies started to die. Yes air, water, food, sun, and love are needed for an abundant life.

For at least the last fifty years, our medical professionals have been scaring us from the sun. We have even told people, after Dr. Cook’s proclaimation that vitamin D would cause birth defects in the 1960’s, to limit any source of vitamin D. (Note: Dr. Cook was friends of the Kennedys and had great political and public attention.) Chronic disease has flourished in America as we have limited our exposure to sun. Now research on vitamin D has shown at least fifty health issues that have been proven by clinical trials to be caused by deficiency in this sun driven vitamin. Is that why all the people that I know over ninety enjoy spending time in the sun and make it a habit?

My excitement is over a second molecule that appears to work along the vitamin D pathways in the body. The two patents that I have been shown, each make ten unique medical claims that are beyond what we would expect of vitamin D. And yet this natural substance is completely safe as it has been consumed for years. The unique novelty of the formulation is in a form that allows the policosanol to enter the cell where our biological life happens. Yes that’s right, just policosanol, an extract primarily of the sun splashed portions of sugar cane and other sun washed plants.

I picked one of the disease claims and decided compare how the unique formulation worked in a similar way as vitamin D. The claim in the patent is that the formulation of policosonal is an inverse agonist for the vitamin D receptor. Hunh? I had heard of agonist and antagonist, but not an inverse agonist. It is apparent to me, that this unique condition has not been defined in a way that a novice could understand. Here is an explanation at Wiki and at Pharmacology Corner

The Metadichol®, a name given the formulation in the patent, puts the vitamin D receptor in a state of action. It most likely is optimizing the performance of vitamin D to allow life. This is where the good stuff begins that causes you to really get excited. The sun created vitamin D has to go through several chemical/biological conversions to get to an active state that causes receptor action. This does not seem to be the case with Metadichol®. Once the policosanol is inside the cell, the receptors take action. Let’s take one of the claims to see if we can show the action of the sun over the years.

MRSA has become a true blight on mankind. The claim is that the Metadichol® healed MRSA. There are thousands of deaths in the US each year from this disease. Its sister, sepsis, claims hundreds of thousands of deaths each year. We know that vitamin D works well as an effective fighter of viruses, but to also treat bacterial infections is amazement. Of course this works in part through the production of a pathogen killer, cathelicidin antimicrobial peptide. The issue has always been, since Niels Finson was awarded the Nobel Prize in 1903 for healing lupus vulgaris with UV light, the side effect of toxicity. The effective treatment of using UV irradiation of serious infections has been phased out. Comments at the Vitamin D Council on sepsis and a history of treating infections with UV irradiation from The Guyer Institute. This history of treating infections is a very important read. Through the use of antibiotics, we have regressed over the last 110 years since the Niels Finson discovery of what nature has given us with the sun.

So what could happen at high levels of vitamin D from UV light without the toxicity – the action of vitamin D without having to worry about your serum calcium getting too high? What if you could keep your vitamin D really active without having to worry about toxicity? We suspect that it would be very effective in treating disease. It appears a unique symphony of action occurs when Metadichol® is introduced. Here, the sun has provided us with two routes of health, vitamin D and a plant derivative, policosanol. A safe nutraceutical that has been consumed since ancient times. Who is this man that came up with a formulation to allow policosanol to be so effective? – Dr. P.R. Raghavan.

Brief Bio: Dr P. R. Raghavan CEO of Nanorx Inc. has a Ph.D. in Organic Chemistry from Oregon State University, USA (1979) and a M.S in Chemistry (1972) from I.I.T Mumbai, India. . He has worked on drug discovery for over 25 years at Columbia University, Max-Planck Institute, Germany, Ciba-Geigy (now Novartis) and Boehringer-Ingelheim Pharmaceuticals. His fields of specialization are CNS, Inflammation, AIDS and ACE inhibitors. His experience in drug research includes Chiral synthesis, process, scale up and clinical research. He has been working for the last 12 years in the area of Nutraceuticals and developing environmentally cost effective solutions for Bio-Diesel production.

As with all great leaps in science, it seems that one person has the vision and makes the jump in paradigm. It is never our huge institutions who make this leap. Institutions develop tunnel vision through the weighing down of institutional armor. Armor allows only a narrow view of life through a very small opening. In conversation with Dr. Raghavan, he believes that nature always gives us robustness and duplication in critical needs of life. For example, he states that we have two eyes, two kidneys, and two lungs. There are many examples in biology that have a second pathway, which depends on what our environment has given us. Dr. Raghavan states that his goal is to give the world a cost effective way to health for everyone.

Dr. Raghavan has licensed marketing companies in India, Asia, and soon the Middle East. This represents about sixty percent of the world’s population. He is presently looking for marketing companies for the rest of the world. His plan is to provide no one with an exclusive. Here is a link to the company licensed in Thailand, Polilex and a link to a store front page that is loaded with information.

It is that evening before the big event. Life with a method of healing disease that is extraordinary. No longer do you have to cry at the loss of someone close because a serious disease has disrupted life. Only love, joy, and peace fill you. I am so excited – Pandemic Survivor.

Vitamin D Deficiency Survivor

Changing the Face of Health with Vitamin D

Tag Archives: Policosanol