Hope for Psoriasis

Nanoscience has brought new hope for psoriasis. There have been many treatments available for psoriasis through the years. Now an over the county supplement has brought a solution. Metadichol is an over the counter supplement that is simply policosanol made into a small particle emulsion. Policosanol is the waxy substance found on the sun-splashed parts of plants. The case studies in this new paper that was just published are amazing in how it resolves the issues around this disease that has no apparent resolution in modern medicine.

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Raghavan PR* Nanorx Inc Chappaqua, New York, United states

Abstract

Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate.

The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz® that blocks IL17 for treatment of plaque psoriasis.

Metadichol® a nano-formulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.

This paper is published in the Journal of Clinical & Experimental Dermatological Research. Citation: Raghavan PR (2017) Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis. J Clin Exp Dermatol Res 8: 433. doi:10.4172/2155-9554.1000433 This is an open access journal.  Link Prr-Psoriasis-paper

Most diseases are connected through a network that is commonly called network pharmacology. The paper shows how Metadichol affects many different diseases through this network. It is definitely worth your time to look at the paper. Presented are seven case studies with psoriasis resolved. Picture here is whole body psoriasis that is resolved in twenty-four weeks. The participants used the spray orally and applied it directly to the areas of concern.

pic psoriasis

Other than Metadichol, I do believe that the over the counter ointment of vitamins A and D is the best. Metadichol appears to work along pathways for A and D.  Typically, vitamins are currently recommended at levels that are to resolve basic body needs without looking at higher levels for improved health.

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Metadichol as Mediator of Inflammatory Response

Note to readers: This article is to notify researchers to the possibilities of Metadichol as a mediator of the AHR-Nrf2 pathway for inflammatory response. Metadichol’s action on nuclear receptors is hugely significant. The importance of Metadichol’s effect is in regulating inflammatory response to outside agents. Outside agents may include drugs, manmade toxins, or even response to light (think sunburn and/or retinal protection). In this paper, it is shown how Metadichol may be significant in treating chemo resistant cancer.

Metadichol ®. A Novel Inverse Agonist of Aryl Hydrocarbon Receptor (AHR) and NRF2 Inhibitor
Journal of Cancer Science and Therapy 

Raghavan, P R
Nanorx Inc., Chappaqua, New York, USA,  

Abstract
Metadichol ® a novel nano-emulsion of lipid alcohols is an Inverse agonist of Vitamin D Receptor (VDR). In this communication, we show that Metadichol is an inverse agonist of the nuclear receptor AHR (Aryl Hydrocarbon receptor) and an inhibitor of NRF2 (Nuclear factor (erythroid-derived 2)-like 2)) and is a transcription factor that is ubiquitously expressed at low levels in all human organs and regulates a primary cellular defense mechanism, tight regulation to maintain cellular homeostasis. AHR is highly expressed in a broad panel of tumors, AHR is induced by 2,3,7,8-tetrachloride-benzo-p-dioxin (TCDD) Metadichol® as a inverse agonist against AHR could be potentially useful in the treatment of such diseases. Strong in vivo evidence suggests that TCDD can stimulate cross-talk between AHR and Nrf2. The constitutive up regulation of Nrf2 signaling appears to drive the cellular proliferation and resistance to chemotherapy in various cancers. Therefore, pharmacological inhibition of Nrf2 by Metadichol ® holds promise as a therapeutic strategy in chemo resistant forms of cancer. 

Here is a link to the PDF: metadichol-AHR-Paper

Metadichol® Induces High Levels of Vitamin C

Vitamin C, also known as ascorbic acid, has shown a remarkable ability to reduce disease. Benefits include the prevention and treatment of scurvy, common cold, boost the immune system, lower hypertension, treatment of lead toxicity, cataracts, treatment of cancer, stroke, elasticity of skin, wound healing, and asthma. Metadichol® has shown it can help maintain high levels of plasma vitamin C without oral supplementation of vitamin C. Metadichol® is a nanoemulsion of policosanol or the waxy substance that is found in high concentration on the sunny parts of plants.

Post LabelLinus Pauling, a two-time Nobel Prize winner, spent a significant effort in promoting vitamin C in the prevention and treatment of disease.  He was scoffed at by the mainstream medical community. Now, there appears to be better acceptance of using vitamin C to treat disease. It is interesting to note that humans, unlike other mammals, do not make vitamin C. Goats are known to make large amounts of vitamin C each day.  A one hundred fifty-pound goat can make as much as 13,000 mg each day. I typically take one to two grams of vitamin C per day.  If my noise is running, I have found that it will stop in a few hours by taking a gram of vitamin C per hour.   

Typical reference range for plasma vitamin C is 0.2 – 2 mg/dL or 11 – 114 µmol/L.  In the study, Dr. Raghavan found that oral supplementation of 5 mg of Metadichol per day raised the plasma vitamin C to or above high normal.  Speculation has been that Metadichol accomplishes this by reducing the requirement for vitamin C as the body gets healthier, recycles vitamin C, or turns on the gene responsible for producing vitamin C.  In any case, this case study shows the effectiveness of Metadichol in reducing disease.
Metadichol® Induced High Levels of Vitamin C: Case Studies
Raghavan PR* Metadichol-Induced-high VitaminC levels (link to paper)
Abstract
We recently reported that Metadichol® [1] brings about a three to four-fold increase in Vitamin C levels in patients without the use of Vitamin C supplementation. In this study of 6 patients who experienced a 5-12 fold increase in plasma Vitamin C levels higher than 80-100 u mol/L level which is the highest reported to date by oral supplementation at high doses of Vitamin C. Metadichol improved in these patients TSH levels, normalized High Blood pressure, fasting glucose levels, reduced eosinophil count, high triglycerides, body fat reduction and increased bone mass, normalized sodium levels, reducing high insulin levels, increased creatinine output in urine and also reducing of Red Cell Distribution width %. Metadichol thus serves as a surrogate for Vitamin C at doses of 5 mg per day as opposed to mega doses that are currently used.

Other articles on Metadichol

Hypertension – Reduced with A Food – Metadichol

Our diets over the last fifty years have been shifted away from fat and toward carbohydrates with the belief that higher amounts of fat were causing cardiovascular disease (CVD). As this move toward higher density carbs occurred, blood pressure also increased along with the issues of higher incidence of CVD and stroke. In the following study, a food substance, that is typically tossed in the processing of sugar cane, was found to reduce blood pressure and c-reactive protein (CRP) and increased circulating vitamin C. The paper describes the action of nano-policosanol as acting along vitamin D pathways.

Here is my blood pressure as I write this at 4 AM–not bad.Hypertension w

Dr. P.R. Raghavan has given us Metadichol, a nano-policosanol, to reduce blood pressure.  Policosanol, as long chain fatty acids, is found in high concentration on sugar cane and the husk of seeds.  Here is the paper that was just published for a sixty-week open label study. The remarkable things are that blood pressure is reduced in only three weeks, the production of vitamin C in humans, and reduced CRP, an indication of reduced inflammation.

Systolic and Diastolic BP Control in Metabolic Syndrome Patients with Metadichol® a Novel Nano Emulsion Lipid – Journal of Cardiology and Cardiovascular Therapy Case Report Volume 5 Issue 2 – May 2017 DOI: 10.19080/JOCCT.2017.05.555660 Metadichol-Hypertension

To combat high-blood pressure the normal course is to:

  • Eat a healthy diet
  • Regular exercise
  • No nicotine use as it shrinks arteries
  • Limit alcohol
  • Maintain a healthy weight

The above is the typical verbiage that you get from your doctor. I wonder just how many times the physicians say that on any given day. It is apparent that a healthy lifestyle is everything. Of course, government and its agencies have failed us in defining a healthy diet. The common American diet was defined to promote the economy. If you don’t believe this then ask yourself this question: Why do we spend almost twice as much on healthcare as we do on food?

Poor eating habits are the cause of many chronic diseases.  Hypertension falls in this category. The first time my realization that diet was critical to controlling blood pressure occurred when I was reading “Protein Power” by Drs. Michael and Mary Eades.  They warned of blood pressure dropping significantly with the reduction of carbohydrates. This raises the question of our health actions over the last fifty years. Reduce the amount of fat and increase sugar?  Sugar has typically not been considered as dangerous, however, I believe it’s the worst policy we could have made. Linus Pauling (interesting that this is the vitamin C guy and Metadichol helps the body produce vitamin C) showed in the 1970s that sugar was more responsible for increased cholesterol than fat through his studies with prisoners.

  • The real solution to maintain a normal blood pressure is to eliminate sugar and flour from your diet. Grains were not meant to be finely divided for consumption by our physiology.  Sugar is not meant to be consumed outside of its normal occurrence in vegetables and fruits. This is what is meant when we are told to consume a healthy diet.

Metadichol will help maintain a lower blood pressure. Metadichol acts in many ways in controlling our biological actions. The beauty of Metadichol is that this food substance has no known side effects. We no longer consume policosanol that is found in the husk of seeds. It appears that our body needs these long chain fatty alcohols. Metadichol is taking the husk into a modern factory and chewing them for us. Remember the words of your mother: Chew your food!  Of course, if you don’t have the right part of the food to be chewed, factory chewing by others is okay.

The irony is that nature gave us policosanol on the plants that are high in sugar, and we throw way nature’s protection from sugar.  We then concentrate the sugar through modern processes and consume it in great amounts.  Results are devastating to our health. We now develop a substance that counteracts the effects of sugar, that nature originally meant us to consumed with the plant.  Sugar drives up serum cholesterol more so than fat. The result of a high sugar diet without the protection of policosanol is CVD and stroke. More irony, the original intent of the Dr. Raghavan was to improve the way policosanol reduced cholesterol as shown by the Cubans. Nature is laughing at us.

One of the very interesting findings in this study was the increase in vitamin C. The paper indicates that humans made vitamin C as part of our physiology.  At some point, one of the three enzymes that makes vitamin C from sugar was no longer produced.  Metadichol appears to turn on the gene responsible for producing this enzyme and higher vitamin C levels happen. This means reduced inflammation, as indicated by a reduction in CRP, and the possibility of a longer lifespan with less disease.

This is really-exciting stuff. The possibility of increased life span with reduced inflammation and disease through a food substance that can easily be supplemented with no side effects–Metadichol.

We took the chewing of grains into the milling operations to help foods be easier to consume. Sugar was concentrated through industrial processes as our body craves this substance. It should also be noted that sugar was concentrated to help in the production of alcohol–another craved substance. Both things, milled grains and concentrated sugar, made food easier to consume and have significant impact on our economy, but they are not healthy. By not being healthy, we again have made a significant impact on our economy with increased healthcare and insurance. And, the government said, “It is good.”  –Pandemic Survivor

Rheumatoid Arthritis and Osteoporosis–Vitamin D Pathways

Arthritis is an autoimmune disease that causes inflammation of the joints.   There are many types of arthritis, but they all seem to come from vitamin D deficiency.  Vitamin D deficiency results in many types of autoimmune diseases. At Vitamin D Deficiency Survivor, we have always encouraged you to be sure that your vitamin D levels are in the high normal range when trying to relieve these very serious diseases.  In this article, we present a case study of a patient with rheumatoid arthritis and osteoporosis that was treated with Metadichol.

Here is the article heading and abstract from the paper recently published by the Journal of Arthritis.

 Screen Shot 2017-05-05 at 06.13.42

Here is the link: Rheumatoid Arthritis and Osteoporosis: A Case Study, P. R. Raghavan, Journal of Arthritis

It is very interesting to note in this article that the patient improved in many markers for health.  C-reactive protein (CRP) is a very important marker and signals an inflammation effect for many pathways of health.   In this study, the patient had a CRP of 1.1 that rose three years later, at baseline before treatment, to 83.  After sixteen weeks of treatment, the patient returned to his normal level—see figure 4.6.  This means that inflammation from all sources was reduced.

The treatment used in this study was Metadichol.  Metadichol is a nanoemulsion of naturally occurring policosanol. The nanoemulsion of policosanol is more easily absorbed and fines its way into the cells where it acts along vitamin D pathways, and the proper expression of many disease related genes (over 700 genes). 

I had arthritis in my pointing finger on my left hand for many years.  With high levels of vitamin D and other vitamins and minerals, it had still not returned to normal.  In three months with treatment of Metadichol, it returned to its normal size and there was no more pain.  Prior, it had been twenty-five percent larger than my right-hand finger.  My sister had significant pain in her knee that she had been told was from arthritis. She described it as very painful.  After treatment with Metadichol for three days, she reported that the pain was reduced by fifty percent.  I know that she was supplementing with a significant amount of vitamin D3. 

The author is very excited about the increase in bone mass density (BMD). This is nothing new to those that understands how vitamin D and minerals work to increase bone mass. Here is a post that I did in 2010 showing that an adequate amount of vitamin D increases bone mass.  The post is about a warning from the FDA for bisphosphonate drugs.  Here is also a link to the paper showing a 23% increase in BMD with vitamin D3 in a nursing home. 

Vitamins and minerals and other nutrients do not work in isolation for health.  It is an adequate amount of all nutrients that is important for health.  We have lost a significant intake of policosanol from processed foods.  Policosanol occurs in the sunny parts of plants, and it occurs at high levels on the husk of seeds and grains.   Think how we have lost access to this vital nutrient by not chewing the husk off foods.  Dr. Raghavan has presented us a solution to this modern problem of processed foods.
–Mark Pegram

Metadichol—Use for Metabolic Disease

Sym DiabeticMetadichol was reported last year as being effective for Type 1 and Type 2 diabetes in case studies.  Two issues for diabetes are insulin resistance and obesity.  A target that is now being researched for metabolic disease is GPR-120.  In research by others, GPR-120 agonist has been found effective in anti-inflammatory, insulin sensitization, and anti-obesity effects.  Metadichol has been found as a GPR-120 agonist.

The paper, Metadichol® A Novel Nano Lipid; GPR-120 Agonist, reaches the conclusion that: “Metadichol has the potential to serve in mitigating diabetes with a broad spectrum of activity and with a safety that with [of]no toxicity at doses of up to 5000 mg/kg [20-22]. Metadichol is a far [more] effective substitute to prescription drugs, which have been largely ineffective in diabetes and have many side effects that add to health care costs.”

Here is a link for you to download the paper: GPR-120 Agonist Metadichol

Mark Pegram

Citation: Raghavan P.R. Metadichol® A Novel Nano Lipid; GPR 120 Agonist. Int J Diabetes Complications. 2017; 1-3.

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.   Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6  https://www.ncbi.nlm.nih.gov/pubmed/24997608

Metadichol as a MRSA Treatment—Case Study

Antibiotic resistant superbugs have been associated with an excess of adverse health conditions. MRSA, a drug-resistant bacterium, is associated with skin disorders such as abscesses and wound infections. The bacteria are also linked to the onset of pneumonia and can ultimately result in sepsis (bloodstream infections).  MRSA infections account for 18,650 deaths in the U.S. in 2005 (Over 80,000 invasive MRSA infections and 11,285 related deaths per year in 2011).

Once again, Metadichol has been effective in treating a very serious disease.  In the case study, the patient used only Metadichol to treat the MRSA infection.  It took only 21 days for it to be completely healed.  Please fill free to download the case study as a pdf file: MRSA-Final

“Metadichol® and MRSA Infections: A Case Report” PR Raghavan, Raghavan, J Infect Dis Ther 2017, 5:2
Abstract
Metadichol® is a nanoemulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol® acts on Nuclear Vitamin D receptors (VDR) that have a ubiquitous presence in cells and tissues of the body to stimulate the immune system and inhibit a variety of disease processes, resulting from viral, bacterial and parasitic infections. Infectious agents can cause disease by avoiding normal host defense mechanisms or by subverting them to promote their replication. They do so by blocking VDR receptor that is responsible for innate immunity, and this suppression of the immune response leads to persistent infections.

We present a case study of a patient who had acquired MRSA infections and how Metadichol® by its actions on the VDR has resolved the problem of this deadly disease without any side effects.

 You may find all the articles and papers for download about Metadichol and various health conditions on my website.

MRSA is a very serious infection that is very difficult to treat.  I had a community acquired infection that started in February of 2009.  After many rounds of doxycycline, here is photo in the infected area in June (The infection is over an inch across). MRSA Photo 2 The infection persisted until I was on doxycycline for a continuous period from August through October (I don’t even want to think about what that did to my microbiome.).  The infection was very painful.  Unfortunately, there was no other treatment available at the time.   I had the infection for nine months and I was lucky that it did not enter my bloodstream.  I was fully replete in serum vitamin D with a level of over 80 ng/ml, 25(OH)D.  The action of the bacteria blocking the VDR is apparent.  If my level of vitamin D had not been high normal, I would hate to think of the outcome as sepsis was a real possibility.

Thank you Dr. Raghavan for developing this unique nanoemulsion that is basically a food substance in a form that is easily absorbed.  MRSA cases in the US are on decline as hospitals and gyms are more caring about sanitized surfaces that prevent spread of the infection.  In 2009, it was not unusual to see gym members walk away without wiping down equipment.  With new awareness of MRSA, all members at my gym wipe down the equipment before and after use.  Please be aware of areas of possible exposure, especially gyms and hospitals.    –Pandemic Survivor