Clotho is one of the three Greek fates that are responsible for the thread of life in Greek mythology. Clotho is known as the spinner of the thread while the others draw out and cut. In our understanding of physiology, we have named the gene responsible for reduced chronic disease—Klotho. The up regulation of klotho appears to significantly reduce chronic disease. A few to consider are cancer, diabetes, rheumatoid arthritis, and coronary artery disease. Have we stumbled unto the gene that is responsible for the fountain of youth?
The klotho gene appears to be regulated by constituents of the vitamin D family, especially the vitamin D nuclear receptor (VDR). In the past, DR. P. R. Raghavan has shown that Metadichol acts to regulate VDR. In the paper, “Metadichol a Novel Agonist of the Anti-aging Klotho Gene in Cancer Cell Lines,” it is shown how Metadichol up regulates klotho in pancreatic cancer cells by as much as ten-fold against controls. Here is the link to the paper: METADIHCOL-KLOTHO
Here is the paper abstract:
Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of life. Klotho is a transmembrane protein known to be a co-receptor for Fibroblast Growth Factor-23. Klotho gene is expressed in a variety of tissues changes in the levels are associated with many diseases. Klotho is a tumor suppressor in breast cancer and its expression is reduced in human pancreatic adenocarcinoma, and treatment with klotho inhibits the growth of pancreatic cancer cells in vitro and in vivo.
Growing evidence suggests that an increase in Klotho (KL) expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. It remains a challenge today to induce Klotho expression. Herein we show that treating pancreatic cancer cells PANC1, MIAPACA and COLO-205 with Metadichol® a novel food-based lipid emulsion of long chain alcohols at picogram/ml, concentration led to a 4 to10 fold increase in Klotho expression as seen quantitative RT-PCR. These results suggest the use of Metadichol® given its constituents that are present in foods we consume every day is a novel therapeutic intervention for pancreatic cancer and other diseases.
The importance of vitamin D and common food compounds like the long chain alcohol lipids that comprise Metadichol is once again shown. We did not have to spend years in Florida looking for the fountain of youth. I bet Ponce de Leon would be very jealous. –Pandemic Survivor.