Hope for Psoriasis

Nanoscience has brought new hope for psoriasis. There have been many treatments available for psoriasis through the years. Now an over the county supplement has brought a solution. Metadichol is an over the counter supplement that is simply policosanol made into a small particle emulsion. Policosanol is the waxy substance found on the sun-splashed parts of plants. The case studies in this new paper that was just published are amazing in how it resolves the issues around this disease that has no apparent resolution in modern medicine.

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Raghavan PR* Nanorx Inc Chappaqua, New York, United states

Abstract

Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune system suppressing medications such as methotrexate.

The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz® that blocks IL17 for treatment of plaque psoriasis.

Metadichol® a nano-formulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases.

This paper is published in the Journal of Clinical & Experimental Dermatological Research. Citation: Raghavan PR (2017) Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis. J Clin Exp Dermatol Res 8: 433. doi:10.4172/2155-9554.1000433 This is an open access journal.  Link Prr-Psoriasis-paper

Most diseases are connected through a network that is commonly called network pharmacology. The paper shows how Metadichol affects many different diseases through this network. It is definitely worth your time to look at the paper. Presented are seven case studies with psoriasis resolved. Picture here is whole body psoriasis that is resolved in twenty-four weeks. The participants used the spray orally and applied it directly to the areas of concern.

pic psoriasis

Other than Metadichol, I do believe that the over the counter ointment of vitamins A and D is the best. Metadichol appears to work along pathways for A and D.  Typically, vitamins are currently recommended at levels that are to resolve basic body needs without looking at higher levels for improved health.

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Historic Breakthrough in Health – Nano Policosanol

“In questions of science, the authority of a thousand is not worth the humble reasoning of a single individual.” – Galileo Galilei

Nature will typically provide at least two pathways or redundancy for anything that is critical to the survival of life. Consider that we have two arms, two kidneys, two eyes, two lungs, etc. If you want to get more technical consider there are two substances to allow homocysteine to go to methionine [trimethylglycine (TMG or Betaine) or the combination of folate with vitamin B12] for the methylation cycle for the expression of genes. The discovery is a substance that works along some of the pathways of vitamin D and enhances the action of nutrients and more.

The remarkable thing about the action of this form of policosanol, as described in the patent, is that it does not drive up serum calcium. This has always been the issue with simply giving the hormone form of vitamin D to patients. Imagine anything that can work on physiological systems of the body without side effects. This natural substance has been consumed forever. Could this be the gift for an extremely healthy life? Like vitamin D in animals, it is also produced by the sun on plants and in many of our foods. The issue has been the ability of the body to absorb it so that it can get to where it needs to be active.   The new discovery is the effectiveness of a small droplet sized emulsion of policosanol. Policosanol is found as a waxy aliphatic alcohol on the leaves of sugar cane and in the husk of many grains and in other plants as well.   This may be reason that diets like the unprocessed paleo diet are so effective.

In conversations with Dr. P.R. Raghavan, he describes the finding as nature’s way of providing a pathway to health for animals who cannot obtain their vitamin D from the sun. He states that his discovery came from observing rats. The first thing that rats do is to eat grass when experiencing long periods without any exposure to sun. Grass makes the waxy alcohol on its leaves. “Rice-field Rats primarily reside in cultivated areas such as rice paddies and grasslands. It [where they reside] is largely dependent on human rice fields and plantations. Rice field rats shelter in burrows in soil, under rocks, and in logs”. It now makes me wonder when I see a dog eat grass if they are trying to achieve health from policosanol. Animals will do whatever is necessary for survival. Dr. Raghavan has been vigorous in making this understanding.

Consider the elephant with its hard dermal layer. How does it get its vitamin D? Or is its health from eating the policosanol in all the plants that it consumes.   “Asian elephants eat a wide variety of plants including grasses, shrubs, bamboo etc. While more than 100 different species may be eaten, only about 10 to 25 foods are likely to make up more than 8% of the diet. The percentage of grasses versus browse eaten varies seasonally; the nutrient value of grass is greatest early in the wet season, while that of leafy browse is higher in the dry season. Elephants do show choice in feeding: foods eaten do not necessarily match foods available. Crops such as bananas, sugar cane and paddy (rice) are favoured.” The sugar cane and paddy rice are very high in policosanol. The serum concentration of 25(OH)D for elephants is low compared to what is considered healthy for animals at an average of 16 ng/ml.

From Dr. Raghavan’s Into to Metadichol: “In the late 1880’s Dutch physician, Christiaan Eijkman was sent to the East Indies(now Indonesia to investigate why beriberi was so widespread in the region. Eijkman observed that hens in his Jakarta laboratory suffered symptons of nerve disease (polyneuritis) that were strikingly similar to those for beriberi – including muscle weakness, nerve degeneration, and paralysis. He then began a series of experiments to try to find a culprit organism, which he assumed was the cause.

He showed that the hens contracted the beriberi like polyneuritis soon after their feed was changed to polished rice – that is, rice whose outer husk had been removed. He also proved that by adding rice bran (the parts removed in polishing) to the hens’ food, the disease could be cured. The outer Husk contains Metadichol (policosanol).” We should clarify here that beriberi is commonly thought to be caused by vitamin B1 (Thiamine) deficiency, but Dr. Raghavan believes that the lack of policosanol was also a cause.

Emulsions are liquid colloids of droplets that are typically less than one micron in size. If you think about homogenized milk, it has fat droplets that range from 300nm to 500nm (0.3 microns to 0.5 microns). There are many small sized droplet emulsions that we normally use. Think about sugar in water, soap in water, or a supplement like vitamin E, vitamin A, vitamin D, vitamin K, etc. in water. The droplet size of the patented emulsion of policosanol, Metadichol®, is about 50nm in size.   This allows for easy absorption through the gut wall or through dermal layers if used topically.

Think about the many pathways that are described by Anthony W. Norman for health in his paper:
The History of the Discovery of Vitamin D and Its Daughter Steroid Hormone
Norman A.W. Ann Nutr Metab 2012;61:199–206 (DOI:10.1159/000343104)
It is truly astonishing the possibilities for health through vitamin D pathways of the vitamin D receptor. Consider this diagram derived from this paper for immune response:

Story02

Let’s take mast cells as an example in an autoimmune response. The mast cells become over active causing significant inflammation. The Metadichol®, name given in the patent, binds to the mast cell VDR and calms it down. As a result, the inflammation that is being caused disappears. Dr. Raghavan says, “Based on our invitro and invivo data Metadichol ® behaves as an agonist for one receptor and an antagonist or neutral antagonist or inverse agonist for another receptor.” The many cells that are involved in an immune reaction and other physiologies with the VDR makes the possibilities for health unlimited.

Dr. Raghavan likes to describe the VDR super family of nuclear receptors and the action of Metadichol® as follows: “A simplified way of looking at it is that the Vitamin D receptor (VDR) present in chromosome 12 in each and every cell is the conductor of an orchestra and he/she, is not relaying to the orchestra the proper cues. This will impact the performance of other members of the orchestra. Metadichol by acting on VDR restores the conductor to peak performance and ensures that both the conductor and the orchestra will perform at their peak potential (read; disease free).”

We have been scared from the sun for the last fifty years. It is time to take advantage of the nature’s gift from the sun, vitamin D in animals and policosanol in plants. This is truly a wonderful and historic discovery in nutritional health. I believe that it is a discovery worthy of the Nobel Prize! – Pandemic Survivor

Knowledge advances not by repeating known facts, but by refuting false dogmas. – Isaac Newton

Brief Bio: Dr P. R. Raghavan CEO of Nanorx Inc. has a Ph.D. in Organic Chemistry from Oregon State University, USA (1979) and a M.S in Chemistry (1972) from I.I.T Mumbai, India. . He has worked on drug discovery for over 25 years at Columbia University, Max-Planck Institute, Germany, Ciba-Geigy (now Novartis) and Boehringer-Ingelheim Pharmaceuticals. His fields of specialization are CNS, Inflammation, AIDS and ACE inhibitors. His experience in drug research includes Chiral synthesis, process, scale up and clinical research. He has been working for the last 12 years in the area of nutraceuticals and developing environmentally cost effective solutions for Bio-Diesel production.

Dr. Raghavan’s Business Philosophy: “Value for Money and Value for Many”

The Miracle of the Sun

You are a child again and it is the night before that long awaited event. It’s the evening before the little league play off game. You dream of that power shot you plan to hit over the right field fence. Perhaps it is the evening before your birthday or Christmas eve. You know that the doll you have been longing for is wrapped and waiting. In bed, you toss and turn in excitement and anticipation. You know what is about to happen is going to be so joyful and loving to you and everyone you know. I did not think this type of excitement can happen to an old man. It has happened to me in the last several weeks.

It is interesting to think of the things that are required for life. A life with abundant good health that is happy and joyful. What are those things that you need ? Without air, you would die in a few minutes. Without water, you would die in a few days. Without food maybe you could make it for a couple of weeks. How long would you make it without the sun? Without the sun you would have no food and possibly not enough heat to survive. And could you survive without love? Think of the trial in the 1930’s when they tried to feed babies without touching them. The trial was ended because the babies started to die. Yes air, water, food, sun, and love are needed for an abundant life.

For at least the last fifty years, our medical professionals have been scaring us from the sun. We have even told people, after Dr. Cook’s proclaimation that vitamin D would cause birth defects in the 1960’s, to limit any source of vitamin D. (Note: Dr. Cook was friends of the Kennedys and had great political and public attention.) Chronic disease has flourished in America as we have limited our exposure to sun. Now research on vitamin D has shown at least fifty health issues that have been proven by clinical trials to be caused by deficiency in this sun driven vitamin. Is that why all the people that I know over ninety enjoy spending time in the sun and make it a habit?

My excitement is over a second molecule that appears to work along the vitamin D pathways in the body. The two patents that I have been shown, each make ten unique medical claims that are beyond what we would expect of vitamin D. And yet this natural substance is completely safe as it has been consumed for years. The unique novelty of the formulation is in a form that allows the policosanol to enter the cell where our biological life happens. Yes that’s right, just policosanol, an extract primarily of the sun splashed portions of sugar cane and other sun washed plants.

I picked one of the disease claims and decided compare how the unique formulation worked in a similar way as vitamin D. The claim in the patent is that the formulation of policosonal is an inverse agonist for the vitamin D receptor.   Hunh? I had heard of agonist and antagonist, but not an inverse agonist. It is apparent to me, that this unique condition has not been defined in a way that a novice could understand. Here is an explanation at Wiki and at Pharmacology Corner

The Metadichol®, a name given the formulation in the patent, puts the vitamin D receptor in a state of action. It most likely is optimizing the performance of vitamin D to allow life. This is where the good stuff begins that causes you to really get excited. The sun created vitamin D has to go through several chemical/biological conversions to get to an active state that causes receptor action. This does not seem to be the case with Metadichol®. Once the policosanol is inside the cell, the receptors take action. Let’s take one of the claims to see if we can show the action of the sun over the years.

MRSA has become a true blight on mankind. The claim is that the Metadichol® healed MRSA. There are thousands of deaths in the US each year from this disease. Its sister, sepsis, claims hundreds of thousands of deaths each year. We know that vitamin D works well as an effective fighter of viruses, but to also treat bacterial infections is amazement. Of course this works in part through the production of a pathogen killer, cathelicidin antimicrobial peptide. The issue has always been, since Niels Finson was awarded the Nobel Prize in 1903 for healing lupus vulgaris with UV light, the side effect of toxicity. The effective treatment of using UV irradiation of serious infections has been phased out. Comments at the Vitamin D Council on sepsis and a history of treating infections with UV irradiation from The Guyer Institute. This history of treating infections is a very important read. Through the use of antibiotics, we have regressed over the last 110 years since the Niels Finson discovery of what nature has given us with the sun.

So what could happen at high levels of vitamin D from UV light without the toxicity – the action of vitamin D without having to worry about your serum calcium getting too high? What if you could keep your vitamin D really active without having to worry about toxicity? We suspect that it would be very effective in treating disease. It appears a unique symphony of action occurs when Metadichol® is introduced.  Here, the sun has provided us with two routes of health, vitamin D and a plant derivative, policosanol. A safe nutraceutical that has been consumed since ancient times. Who is this man that came up with a formulation to allow policosanol to be so effective? – Dr. P.R. Raghavan.

Brief Bio: Dr P. R. Raghavan CEO of Nanorx Inc. has a Ph.D. in Organic Chemistry from Oregon State University, USA (1979) and a M.S in Chemistry (1972) from I.I.T Mumbai, India. . He has worked on drug discovery for over 25 years at Columbia University, Max-Planck Institute, Germany, Ciba-Geigy (now Novartis) and Boehringer-Ingelheim Pharmaceuticals. His fields of specialization are CNS, Inflammation, AIDS and ACE inhibitors. His experience in drug research includes Chiral synthesis, process, scale up and clinical research. He has been working for the last 12 years in the area of Nutraceuticals and developing environmentally cost effective solutions for Bio-Diesel production.

As with all great leaps in science, it seems that one person has the vision and makes the jump in paradigm. It is never our huge institutions who make this leap. Institutions develop tunnel vision through the weighing down of institutional armor. Armor allows only a narrow view of life through a very small opening. In conversation with Dr. Raghavan, he believes that nature always gives us robustness and duplication in critical needs of life. For example, he states that we have two eyes, two kidneys, and two lungs. There are many examples in biology that have a second pathway, which depends on what our environment has given us. Dr. Raghavan states that his goal is to give the world a cost effective way to health for everyone.

Dr. Raghavan has licensed marketing companies in India, Asia, and soon the Middle East. This represents about sixty percent of the world’s population. He is presently looking for marketing companies for the rest of the world. His plan is to provide no one with an exclusive. Here is a link to the company licensed in Thailand, Polilex and a link to a store front page that is loaded with information.  

It is that evening before the big event. Life with a method of healing disease that is extraordinary. No longer do you have to cry at the loss of someone close because a serious disease has disrupted life. Only love, joy, and peace fill you. I am so excited – Pandemic Survivor.