The Microbiome – A New Model for Health

sunday musting 2Buckminster Fuller: “You never change things by fighting the existing reality. To change something, build a new model that makes the existing model obsolete.”

What would a new model in medicine look like? Perhaps that new model has already been developed, but we have not begun to understand it. In the late 1990’s, a new paradigm in health was published. That is we live in a symbiotic relationship with a community of microbes. There are ten times more cells in this community of microbes than human cells within the body. There is also significantly more DNA in this community than human DNA that was discovered when trying to map the genome. Our model of genes or mutations of genes that affect our health is a poor model when we have ten times or more the genetics living with us that has to be properly expressed.

“You mean there is this tiny community of life living within our personal biosphere?” – Pandemic Survivor

“Yes, that is absolutely correct.” – A Cognizant Commentor “

“Hello, Mr. A. C. Commenter, where did you come from?” – PS

“It’s not commenter, it is Commentor. You introduced me a few weeks ago in a musing. You also got my name wrong in that post. A commenter is one that makes random suggestions where a commentor is one that typically has knowledge of a particular subject.” – ACC

“Sorry.” PS

“So there are ten times as many cells living in my body than my own human cells. That is certainly unnerving to think I have my own personal zoo living all over my body. Are they just in my gut?” –PS

“No they live everywhere in your body. There are literally trillions of these organisms that call your body home. A tiny bio home which lives everywhere in your body. Because this colony lives within you, it can either make you or break you. “ – ACC

“What do you mean by ‘make you or break you’?” -PS

“The way I like to think about our relationship with this colony is to imagine a bee keeper. The bee keeper goes about taking care of the hive to be sure there is plenty of fresh blossoms for them to collect the needs of the hive. Also the bee keeper makes sure that the colony always has a fresh place to store honey. The keeper may also take some of the honey for his own needs.  Certainly the bees also pollinate the fruits and vegetables in the keepers garden for an abundant yield.“  –ACC

“Wow! That is really interesting. I have never thought of anything like this. So I have to keep this living colony happy so that I am well? I always thought that anti bio substances were necessary to kept pathogens from causing disease. Every type of cleaner that I have purchased lately has some form of antibiotic in it. Even the dish washing detergent I bought last week.” – PS

“It is unfortunate that we have used such a large volume of chemicals that has significant impact on our friends that live with us. This destruction of their colonies has caused us much harm. If you think of it like the bee keeper analogy, so goes the colony, so goes the good fortune of the bee keeper. “ –ACC

“Interesting, a healthy hive, a healthy life or living symbiotically.” -PC

“Yes, that is exactly right. If you go out and kick over the hive, you will create an angry swarm of bees that attack you to protect their home. If you give them a place to live, and some nectar to keep them calm, they will re-track their anger. This may account for infectious disease as well as autoimmune diseases and allergies. It may also account for biochemical missteps as well. You introduce a pathogen (or a cougar in the hen house) that angers the hive or a substance that angers the hive and the attack of inflammation begins. You give them their natural needs and the hive calms down and stops attacking you. Pharmaceuticals under our existing paradigm of working on just human cells may actually anger the hive and cause severe inflammation commonly called side effects.” -ACC

“So ole Hippocrates was right two millennia ago. Medicine really is about food and keeping the ‘hive’ happy.” – PS

“Our present model of health has given us many great things for emergency healing, but I believe all the other diseases and possibly severe infections may be treated by keeping the microbiome well. I suspect this is the reason that chronic disease has not gotten any better since the understanding of DNA and the Central Dogma of molecular biology. We have totally ignored the environmental effect on expression of DNA and the DNA of our microbiome. The central dogma of saying that a gene or a gene mutation is the reason for disease is just wrong. It is like saying that you can throw a set of blueprints on a vacant lot and expect a building to spring up. It is the acts of the contractors and the skill of the crews that give you the building. The better you treat the workers, the better the building is likely to be.” – ACC

“That certainly is a new model of health. They actually named our present model central dogma? What arrogance! How can I learn more?” –PS

“Just read.” –ACC

Wiki – Microbiome

Central Dogma

National Institute of Health – Microbiome

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